Robert C. McLeay
YOU?
Author Swipe
View article: Evaluation of amikacin use and comparison of the models implemented in two Bayesian forecasting software packages to guide dosing
Evaluation of amikacin use and comparison of the models implemented in two Bayesian forecasting software packages to guide dosing Open
Aims Bayesian forecasting software can assist in guiding therapeutic drug monitoring (TDM)‐based dose adjustments for amikacin to achieve therapeutic targets. This study aimed to evaluate amikacin prescribing and TDM practices, and to dete…
View article: 1574. Predictive Ability and Bias of Vancomycin Population PK Models in an Obese Adult Population
1574. Predictive Ability and Bias of Vancomycin Population PK Models in an Obese Adult Population Open
Background Accurate dosing of vancomycin is difficult due to high inter-individual variability of vancomycin pharmacokinetics (PK), and is particularly challenging in obese patients. Vancomycin is hydrophilic, yet total body weight (TBW) h…
View article: 1599. AUC24 Vancomycin Bayesian-Based Dosing: Increasing Therapeutic Target Attainment with Decreased TDM Cost
1599. AUC24 Vancomycin Bayesian-Based Dosing: Increasing Therapeutic Target Attainment with Decreased TDM Cost Open
Background Vancomycin efficacy is optimally predicted by the area under the concentration–time profile (AUC24), however, traditional AUC24-based dosing methods involve analytic PK calculations that require both peak and trough drug levels,…
View article: P339 Application of Bayesian modelling with infliximab to determine optimal patient-specific regimens
P339 Application of Bayesian modelling with infliximab to determine optimal patient-specific regimens Open
Infliximab (IFX), a chimeric monoclonal IgG1 anti-TNF-α antibody, is often used to treat inflammatory bowel disease (IBD), particularly if non-biologic treatments have failed. IFX is usually administered intravenously at the approved stand…
View article: Expression and Methylation of <i>BDNF</i> in Human Schizophrenia Brain
Expression and Methylation of <i>BDNF</i> in Human Schizophrenia Brain Open
Objective: To examine the combined effect of the BDNF Val66Met (rs6265) polymorphism and BDNF DNA methylation on transcriptional regulation of the BDNF gene. Methods: DNA methylation profiles were generated for CpG sites proximal to Val66M…
View article: Expression and methylation of <i>BDNF</i> in the human brain in schizophrenia
Expression and methylation of <i>BDNF</i> in the human brain in schizophrenia Open
Objectives: To examine the combined effect of the BDNF Val66Met (rs6265) polymorphism and BDNF DNA methylation on transcriptional regulation of the BDNF gene. Methods: DNA methylation profiles were generated for CpG sites proximal to Val66…