Robert C. Thompson
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View article: Policy Brief: The global plastics treaty: What is the role of bio-based plastic, biodegradable plastic and bioplastic? (possible core obligation 8)
Policy Brief: The global plastics treaty: What is the role of bio-based plastic, biodegradable plastic and bioplastic? (possible core obligation 8) Open
This policy brief covers alternatives to conventional, durable fossil-based plastics. It addresses their potential advantages and disadvantages, limitations and risks as well as the role of the Global Plastics Treaty.
View article: Neurotransmission-related gene expression in the frontal pole is altered in subjects with bipolar disorder and schizophrenia
Neurotransmission-related gene expression in the frontal pole is altered in subjects with bipolar disorder and schizophrenia Open
The frontal pole (Brodmann area 10, BA10) is the largest cytoarchitectonic region of the human cortex, performing complex integrative functions. BA10 undergoes intensive adolescent grey matter pruning prior to the age of onset for bipolar …
View article: Filter type gas sampler with filter consolidation
Filter type gas sampler with filter consolidation Open
Disclosed is an apparatus for automatically consolidating a filter or, more specifically, an apparatus for drawing a volume of gas through a plurality of sections of a filter, whereafter the sections are subsequently combined for the purpo…
View article: qPCR: Neurotransmission-related gene expression in post-mortem tissue from frontal cortex region Brodmann Area 10 (BA10) from subjects with Schizophrenia and Bipolar Disorder
qPCR: Neurotransmission-related gene expression in post-mortem tissue from frontal cortex region Brodmann Area 10 (BA10) from subjects with Schizophrenia and Bipolar Disorder Open
DATA ABSTRACT: Brodmann Area 10 (BA10) is the largest cytoarchitectonic region of the human cortex, performing complex integrative functions. BA10 undergoes intensive adolescent grey matter pruning around the average age …
View article: Neurotransmission-Related Gene Expression in the Frontal Pole (Brodmann Area 10) is Altered in Subjects with Bipolar Disorder and Schizophrenia
Neurotransmission-Related Gene Expression in the Frontal Pole (Brodmann Area 10) is Altered in Subjects with Bipolar Disorder and Schizophrenia Open
Brodmann Area 10 (BA10) is the largest cytoarchitectonic region of the human cortex, performing complex integrative functions. BA10 undergoes intensive adolescent grey matter pruning around the average age of onset for Bipolar disorder (BP…
View article: Developmental Programming: Prenatal Testosterone Excess on Liver and Muscle Coding and Noncoding RNA in Female Sheep
Developmental Programming: Prenatal Testosterone Excess on Liver and Muscle Coding and Noncoding RNA in Female Sheep Open
Prenatal testosterone (T)-treated female sheep manifest peripheral insulin resistance, ectopic lipid accumulation, and insulin signaling disruption in liver and muscle. This study investigated transcriptional changes and transcriptome sign…
View article: Genetic Liability for Internalizing Versus Externalizing Behavior Manifests in the Developing and Adult Hippocampus: Insight From a Meta-analysis of Transcriptional Profiling Studies in a Selectively Bred Rat Model
Genetic Liability for Internalizing Versus Externalizing Behavior Manifests in the Developing and Adult Hippocampus: Insight From a Meta-analysis of Transcriptional Profiling Studies in a Selectively Bred Rat Model Open
This data release accompanies the manuscript "Genetic liability for internalizing versus externalizing behavior manifests in the developing and adult hippocampus: Insight from a meta-analysis of transcriptional profiling studies in a se…
View article: Single-Cell Analysis of the Gene Expression Effects of Developmental Lead (Pb) Exposure on the Mouse Hippocampus
Single-Cell Analysis of the Gene Expression Effects of Developmental Lead (Pb) Exposure on the Mouse Hippocampus Open
Lead (Pb) exposure is ubiquitous with permanent neurodevelopmental effects. The hippocampus brain region is involved in learning and memory with heterogeneous cellular composition. The hippocampus cell type-specific responses to Pb are unk…
View article: Combined microRNA and mRNA detection in mammalian retinas by in situ hybridization chain reaction
Combined microRNA and mRNA detection in mammalian retinas by in situ hybridization chain reaction Open
Improved in situ hybridization methods for mRNA detection in tissues have been developed based on the hybridization chain reaction (HCR). We show that in situ HCR methods can be used for the detection of microRNAs in tissue sections from m…
View article: Single cell analysis of the effects of developmental lead (Pb) exposure on the hippocampus
Single cell analysis of the effects of developmental lead (Pb) exposure on the hippocampus Open
Background Lead (Pb) exposure is ubiquitous and has permanent developmental effects on childhood intelligence and behavior and adulthood risk of dementia. The hippocampus is a key brain region involved in learning and memory, and its cellu…
View article: Genetic liability for internalizing versus externalizing behavior manifests in the developing and adult hippocampus: Insight from a meta-analysis of transcriptional profiling studies in a selectively-bred rat model
Genetic liability for internalizing versus externalizing behavior manifests in the developing and adult hippocampus: Insight from a meta-analysis of transcriptional profiling studies in a selectively-bred rat model Open
Background For over 16 years, we have selectively bred rats to show either high or low levels of exploratory activity within a novel environment. These “bred High Responder” (bHR) and “bred Low Responder” (bLR) rats serve as a model for te…
View article: Developmental Programming: Contribution of Epigenetic Enzymes to Antral Follicular Defects in the Sheep Model of PCOS
Developmental Programming: Contribution of Epigenetic Enzymes to Antral Follicular Defects in the Sheep Model of PCOS Open
Prenatal testosterone (T)-treated sheep, similar to women with polycystic ovary syndrome (PCOS), manifest oligo-/anovulation, hyperandrogenism, and polyfollicular ovary. The polyfollicular ovarian morphology, a result of persistence of ant…
View article: Inference of cell type content from human brain transcriptomic datasets illuminates the effects of age, manner of death, dissection, and psychiatric diagnosis
Inference of cell type content from human brain transcriptomic datasets illuminates the effects of age, manner of death, dissection, and psychiatric diagnosis Open
Psychiatric illness is unlikely to arise from pathology occurring uniformly across all cell types in affected brain regions. Despite this, transcriptomic analyses of the human brain have typically been conducted using macro-dissected tissu…
View article: Early rearing history influences oxytocin receptor epigenetic regulation in rhesus macaques
Early rearing history influences oxytocin receptor epigenetic regulation in rhesus macaques Open
Significance Epigenetically programmed stress adaptation may be a conduit for informing offspring of environmental challenge. We employed ChIP-sequencing to examine effects of early environment on epigenetic regulation using hippocampal sa…
View article: Learning Experimental Design through Targeted Student-Centric Journal Club with Screencasting.
Learning Experimental Design through Targeted Student-Centric Journal Club with Screencasting. Open
Knowledge and application of experimental design principles are essential components of scientific methodology, and experience with these skills is fundamental for participating in scientific research. However, undergraduates often enter t…
View article: Inference of Cell Type Composition from Human Brain Transcriptomic Datasets Illuminates the Effects of Age, Manner of Death, Dissection, and Psychiatric Diagnosis
Inference of Cell Type Composition from Human Brain Transcriptomic Datasets Illuminates the Effects of Age, Manner of Death, Dissection, and Psychiatric Diagnosis Open
Psychiatric illness is unlikely to arise from pathology occurring uniformly across all cell types in affected brain regions. Despite this, transcriptomic analyses of the human brain have typically been conducted using macro-dissected tissu…
View article: SNX27 and SORLA Interact to Reduce Amyloidogenic Subcellular Distribution and Processing of Amyloid Precursor Protein
SNX27 and SORLA Interact to Reduce Amyloidogenic Subcellular Distribution and Processing of Amyloid Precursor Protein Open
Many genes have been identified as risk factors for Alzheimer's disease (AD), and a large proportion of these genes function to limit production or toxicity of the AD-associated amyloid β (Aβ) peptide. Whether and how these genes precisely…
View article: The microRNA network is altered in anterior cingulate cortex of patients with unipolar and bipolar depression
The microRNA network is altered in anterior cingulate cortex of patients with unipolar and bipolar depression Open
View article: Genetic background and epigenetic modifications in the core of the nucleus accumbens predict addiction-like behavior in a rat model
Genetic background and epigenetic modifications in the core of the nucleus accumbens predict addiction-like behavior in a rat model Open
Significance Determining the factors that render an individual more susceptible or resilient to cocaine addiction has great implications for treatment. We exploit a unique model to demonstrate that genetic differences in vulnerability to c…
View article: Cecal Ligation and Puncture Results in Long-Term Central Nervous System Myeloid Inflammation
Cecal Ligation and Puncture Results in Long-Term Central Nervous System Myeloid Inflammation Open
Survivors of sepsis often experience long-term cognitive and functional decline. Previous studies utilizing lipopolysaccharide injection and cecal ligation and puncture in rodent models of sepsis have demonstrated changes in depressive-lik…
View article: Evidence for alterations of the glial syncytial function in major depressive disorder
Evidence for alterations of the glial syncytial function in major depressive disorder Open
View article: CCDC 1404655: Experimental Crystal Structure Determination
CCDC 1404655: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …