Hwa‐Chain Robert Wang
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View article: Decoupled Classifier Knowledge Distillation
Decoupled Classifier Knowledge Distillation Open
Mainstream knowledge distillation methods primarily include self-distillation, offline distillation, online distillation, output-based distillation, and feature-based distillation. While each approach has its respective advantages, they ar…
View article: Structure-Based Identification of Novel Histone Deacetylase 4 (HDAC4) Inhibitors
Structure-Based Identification of Novel Histone Deacetylase 4 (HDAC4) Inhibitors Open
Histone deacetylases (HDACs) are important cancer drug targets. Existing FDA-approved drugs target the catalytic pocket of HDACs, which is conserved across subfamilies (classes) of HDAC. However, engineering specificity is an important goa…
View article: Construction and Validation of Chicken Immune scFv Antibody Library against Helicobacter pylori
Construction and Validation of Chicken Immune scFv Antibody Library against Helicobacter pylori Open
Accurate diagnostic techniques and effective therapeutic methods are required to treat H. pylori. The application of chicken single-chain variable fragment (scFv) antibodies may diagnose and treat H. pylori. This study used the phage displ…
View article: A Single-Step Method for Harvesting Influenza Viral Particles from MDCK Cell Culture Supernatant with High Yield and Effective Impurity Removal
A Single-Step Method for Harvesting Influenza Viral Particles from MDCK Cell Culture Supernatant with High Yield and Effective Impurity Removal Open
Influenza vaccines, which are recommended by the World Health Organization (WHO), are the most effective preventive measure against influenza virus infection. Madin–Darby canine kidney (MDCK) cell culture is an emerging technology used to …
View article: [Retracted] The therapeutic effect of artesunate on rosacea through the inhibition of the JAK/STAT signaling pathway
[Retracted] The therapeutic effect of artesunate on rosacea through the inhibition of the JAK/STAT signaling pathway Open
Following the publication of this paper, it was drawn to the Editor's attention by a concerned reader that the GAPDH control western blotting data shown in Fig. 4A were strikingly similar to data appearing in different form in another arti…
View article: Construction and validation an autophagy and immune-related prognostic signature in breast cancer
Construction and validation an autophagy and immune-related prognostic signature in breast cancer Open
Increasing evidence has revealed the association between autophagy and tumor microenvironment. However, reliable prognostic signatures based on a combination of autophagy and immune-relate genes have not been well-established. This study a…
View article: Combination of AAV-delivered tumor suppressor PTEN with anti-PD-1 loaded depot gel for enhanced antitumor immunity
Combination of AAV-delivered tumor suppressor PTEN with anti-PD-1 loaded depot gel for enhanced antitumor immunity Open
Recent clinical studies have shown that mutation of phosphatase and tensin homolog deleted on chromosome 10 (PTEN) gene in cancer cells may be associated with immunosuppressive tumor microenvironment (TME) and poor response to immune check…
View article: Current understanding of the association between Amyotrophic lateral sclerosis and frontotemporal dementia: Letter to Editor
Current understanding of the association between Amyotrophic lateral sclerosis and frontotemporal dementia: Letter to Editor Open
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two devastating neurodegenerative diseases that have a significant overlap in clinical and pathological features (1).ALS is a progressive motor neuron disease that l…
View article: Structure-based identification of novel histone deacetylase 4 (HDAC4) inhibitors
Structure-based identification of novel histone deacetylase 4 (HDAC4) inhibitors Open
Histone deacetylases (HDACs) are important cancer drug targets. Existing FDA-approved drugs target the catalytic pocket of HDACs, which is conserved across subfamilies (classes) of HDAC. Here, we use molecular modeling approaches to identi…
View article: TEOA Promotes Autophagic Cell Death via ROS-Mediated Inhibition of mTOR/p70S6k Signaling Pathway in Pancreatic Cancer Cells
TEOA Promotes Autophagic Cell Death via ROS-Mediated Inhibition of mTOR/p70S6k Signaling Pathway in Pancreatic Cancer Cells Open
Pancreatic cancer is a common malignant tumor with high mortality, and novel therapeutic options have focused on ameliorating its poor prognosis. TEOA, a traditional Chinese herbal medicine, exhibits anti-inflammatory and anti-cancer activ…
View article: Overcoming the compensatory elevation of NRF2 renders hepatocellular carcinoma cells more vulnerable to disulfiram/copper-induced ferroptosis
Overcoming the compensatory elevation of NRF2 renders hepatocellular carcinoma cells more vulnerable to disulfiram/copper-induced ferroptosis Open
Hepatocellular carcinoma (HCC) is one of the paramount causes of cancer-related death worldwide. Despite recent advances have been made in clinical treatments of HCC, the general prognosis of patients remains poor. Therefore, it is imperat…
View article: Clinical and computed tomography features of extended-spectrum β-lactamase-producing Klebsiella pneumoniae liver abscess
Clinical and computed tomography features of extended-spectrum β-lactamase-producing Klebsiella pneumoniae liver abscess Open
Background Klebsiella pneumoniae (KP) is the primary pathogen associated with pyogenic liver abscesses (PLAs). Moreover, there has been an increase in the proportion of extended-spectrum beta-lactamase (ESBL)-producing KP. However, the cli…
View article: Compensatory combination of romidepsin with gemcitabine and cisplatin to effectively and safely control urothelial carcinoma
Compensatory combination of romidepsin with gemcitabine and cisplatin to effectively and safely control urothelial carcinoma Open
Background Human urothelial carcinoma (UC) has a high tendency to recur and progress to life-threatening advanced diseases. Advanced therapeutic regimens are needed to control UC development and recurrence. Methods We pursued in vitro and …
View article: SOCS3 control the activity of NF-κB induced by HSP70<i>via</i>degradation of MyD88-adapter-like protein (Mal) in IPEC-J2 cells
SOCS3 control the activity of NF-κB induced by HSP70<i>via</i>degradation of MyD88-adapter-like protein (Mal) in IPEC-J2 cells Open
Hyperthermia in pigs induces suppressor of cytokine signaling (SOCS) 3 and SOCS4 expression in intestinal gut and causes disruption of inflammation cytokine production. These changes may affect the development of inflammatory bowel disease…
View article: Cytoplasmic Translocation of Nucleolar Protein NOP53 Promotes Viral Replication by Suppressing Host Defense
Cytoplasmic Translocation of Nucleolar Protein NOP53 Promotes Viral Replication by Suppressing Host Defense Open
NOP53 is a tumor suppressor protein located in the nucleolus and is translocated to the cytoplasm during infection by vesicular stomatitis virus (VSV) and herpes simplex virus type 1 (HSV-1), as shown in our previous study. Cytoplasmic NOP…
View article: The therapeutic effect of artesunate on rosacea through the inhibition of the JAK/STAT signaling pathway
The therapeutic effect of artesunate on rosacea through the inhibition of the JAK/STAT signaling pathway Open
Acne rosacea is a type of chronic dermatosis with the characteristics of erubescence, angiotelectasis and pustule formation. However, current treatment methods are limited due to the side effects. Artesunate demonstrated a promising therap…
View article: A cocktail of p16INK4a and Ki-67, p16INK4a and minichromosome maintenance protein 2 as triage tests for human papillomavirus primary cervical cancer screening
A cocktail of p16INK4a and Ki-67, p16INK4a and minichromosome maintenance protein 2 as triage tests for human papillomavirus primary cervical cancer screening Open
Most human papillomavirus (HPV) infections are transient and additional triage approaches should be built after HPV-based primary cervical cancer screening. We evaluated the accuracy of p16/Ki-67 and p16/mcm2 dual staining as biomarkers fo…