Robert C. Welsh
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View article: Vaccination in Patients with Cardiovascular Disease: A Case-Based Approach and Contemporary Review
Vaccination in Patients with Cardiovascular Disease: A Case-Based Approach and Contemporary Review Open
Vaccination is a crucial preventative strategy, particularly in individuals with cardiovascular (CV) disease (CVD). People living with CVD are at increased risk of morbidity and mortality from vaccine-preventable infections such as influen…
View article: Muscle oxygen uptake and recovery kinetics during plantar flexion exercise in long-term breast cancer survivors previously treated with cardiotoxic therapy
Muscle oxygen uptake and recovery kinetics during plantar flexion exercise in long-term breast cancer survivors previously treated with cardiotoxic therapy Open
Background Reduced aerobic endurance in older breast cancer survivors (BCS) has been primarily attributed to cardiac factors; however, the role of skeletal muscle impairments has been less studied. Purpose To compare muscle oxygen uptake (…
View article: Looking beyond LVEF: cardiac and skeletal muscle function in long-term breast cancer survivors with normal versus reduced peak oxygen uptake
Looking beyond LVEF: cardiac and skeletal muscle function in long-term breast cancer survivors with normal versus reduced peak oxygen uptake Open
Background Peak oxygen uptake (VO2peak) is a marker of cardiovascular disease (CVD) and heart failure (HF) risk that is gaining interest in breast cancer survivors (BCS) treated with cardiotoxic therapy. However, the factors contributing t…
View article: Short-term and long-term outcome prediction for patients with coronary artery disease using machine learning and comprehensive multi-center patient data
Short-term and long-term outcome prediction for patients with coronary artery disease using machine learning and comprehensive multi-center patient data Open
Background Revascularization decision-making for patients with coronary artery disease (CAD) can benefit from accurate patient outcome prediction. While previous studies have employed data-driven methods including machine learning (ML) to …
View article: Review of Transcatheter Aortic Valve Insertion (TAVI) Clinician Opinions on the Canadian Cardiovascular Society Post-TAVI Driving Guidelines
Review of Transcatheter Aortic Valve Insertion (TAVI) Clinician Opinions on the Canadian Cardiovascular Society Post-TAVI Driving Guidelines Open
The majority of Canadian TAVI programs expressed that a 1-month driving restriction period was overly cautious and that shorter restriction periods would be more appropriate. Ultimately, before any change to post-TAVI driving restrictions …
View article: Dual Pathway Inhibition in Patients with Atherosclerosis with or without Heart Failure: Insights from the XATOA Registry
Dual Pathway Inhibition in Patients with Atherosclerosis with or without Heart Failure: Insights from the XATOA Registry Open
In a generalizable cohort of patients with atherosclerotic disease and HF, the use of DPI therapy is associated with outcomes similar to those observed in recent randomized controlled clinical trials.
View article: More Monuments: Congressional Limits to Presidential Power under the Antiquities Act and the Role Courts Play
More Monuments: Congressional Limits to Presidential Power under the Antiquities Act and the Role Courts Play Open
View article: What Guidelines Say About Risk Reduction: Major Data on the Link Between Lipid Lowering and Outcomes
What Guidelines Say About Risk Reduction: Major Data on the Link Between Lipid Lowering and Outcomes Open
View article: Is there a role for pre-hospital administration of potent antiplatelet therapy in ST-segment elevation myocardial infarction?
Is there a role for pre-hospital administration of potent antiplatelet therapy in ST-segment elevation myocardial infarction? Open
View article: Effect of Peripheral Interventions in Patients with Peripheral Artery Disease Receiving Rivaroxaban and Aspirin: Analyses from the XATOA Registry
Effect of Peripheral Interventions in Patients with Peripheral Artery Disease Receiving Rivaroxaban and Aspirin: Analyses from the XATOA Registry Open
View article: Cardiovascular pathology, inheritance and prognosis in a familial cohort of Loeys-Dietz type III
Cardiovascular pathology, inheritance and prognosis in a familial cohort of Loeys-Dietz type III Open
View article: Immunomodulatory therapy in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS, MIS-C; RECOVERY): a randomised, controlled, open-label, platform trial
Immunomodulatory therapy in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS, MIS-C; RECOVERY): a randomised, controlled, open-label, platform trial Open
Medical Research Council and National Institute of Health Research.
View article: Identifying the highest risk vascular patients: Insights from the XATOA registry
Identifying the highest risk vascular patients: Insights from the XATOA registry Open
Patients with polyvascular disease represent a substantial subset of patients in clinical practice and should be prioritized to receive maximal medical therapy including low dose rivaroxaban (2.5 mg BID) and aspirin.
View article: Antiplatelet Pretreatment Before Angiography With Anticipated or Planned Percutaneous Coronary Intervention in Stable Ischemic Heart Disease
Antiplatelet Pretreatment Before Angiography With Anticipated or Planned Percutaneous Coronary Intervention in Stable Ischemic Heart Disease Open
View article: Fifteen-year mortality outcomes in the APEX-AMI trial compared to the general ST-elevation myocardial infarction population in Canada: Exploring lessons from numerators and denominators
Fifteen-year mortality outcomes in the APEX-AMI trial compared to the general ST-elevation myocardial infarction population in Canada: Exploring lessons from numerators and denominators Open
Background It is well established that patients enrolled in clinical trials tend to be younger, more likely male, and have fewer comorbidities. Moreover, sites that enroll patients in randomized trials (RT) are often tertiary care centres …
View article: 65 The Impact of PTSD and Mild Cognitive Impairment on Resting State Brain Functional Connectivity in World Trade Center Responders
65 The Impact of PTSD and Mild Cognitive Impairment on Resting State Brain Functional Connectivity in World Trade Center Responders Open
Objective: Functional connectivity of the default mode network (DMN) during rest has been shown to be different among adults with Mild Cognitive Impairment (MCI) relative to aged-matched individuals without MCI and is predictive of transit…
View article: STREAM-2: Half-Dose Tenecteplase or Primary Percutaneous Coronary Intervention in Older Patients With ST-Segment–Elevation Myocardial Infarction: A Randomized, Open-Label Trial
STREAM-2: Half-Dose Tenecteplase or Primary Percutaneous Coronary Intervention in Older Patients With ST-Segment–Elevation Myocardial Infarction: A Randomized, Open-Label Trial Open
BACKGROUND: ST-segment–elevation myocardial infarction (STEMI) guidelines recommend pharmaco-invasive treatment if timely primary percutaneous coronary intervention (PCI) is unavailable. Full-dose tenecteplase is associated with an increas…
View article: Outcomes Among Patients Hospitalized With Non–COVID-19 Conditions Before and During the COVID-19 Pandemic in Alberta and Ontario, Canada
Outcomes Among Patients Hospitalized With Non–COVID-19 Conditions Before and During the COVID-19 Pandemic in Alberta and Ontario, Canada Open
Importance The association of inpatient COVID-19 caseloads with outcomes in patients hospitalized with non–COVID-19 conditions is unclear. Objective To determine whether 30-day mortality and length of stay (LOS) for patients hospitalized w…
View article: The Challenges of Identifying Patients With Peripheral Artery Disease Utilizing Administrative Databases
The Challenges of Identifying Patients With Peripheral Artery Disease Utilizing Administrative Databases Open
View article: Genetic-Guided Oral P2Y12 Inhibitor Selection and Cumulative Ischemic Events After Percutaneous Coronary Intervention
Genetic-Guided Oral P2Y12 Inhibitor Selection and Cumulative Ischemic Events After Percutaneous Coronary Intervention Open
View article: Patients acceptance and comprehension to written and verbal consent (PAC–VC)
Patients acceptance and comprehension to written and verbal consent (PAC–VC) Open
Background Acute myocardial infarction (AMI) research is challenging as it requires enrollment of acutely ill patients. Patients are generally in a suboptimal state for providing informed consent. Patients’ understanding to verbal assents …
View article: Transaxillary Transcatheter Aortic Valve Replacement in a Patient With Previous Aortic Valve-Sparing Root Replacement: A Case Report
Transaxillary Transcatheter Aortic Valve Replacement in a Patient With Previous Aortic Valve-Sparing Root Replacement: A Case Report Open
Novel Teaching Points•Several options are available for alternative access for TAVR.•Transaxillary TAVR with a previous David procedure has not been described.•In patients with previous aortic root surgery, TAVR is a safe option.•Considera…
View article: Economics of Minimalist Transcatheter Aortic Valve Replacement: Results From the 3M-TAVR Economic Study
Economics of Minimalist Transcatheter Aortic Valve Replacement: Results From the 3M-TAVR Economic Study Open
Background: The 3M-TAVR trial (3M-Transcatheter Aortic Valve Replacement) demonstrated the feasibility and safety of next-day hospital discharge after transfemoral TAVR with implementation of a minimalist pathway. However, the economic imp…
View article: Complete Revascularization vs Culprit Lesion–Only Percutaneous Coronary Intervention for Angina-Related Quality of Life in Patients With ST-Segment Elevation Myocardial Infarction
Complete Revascularization vs Culprit Lesion–Only Percutaneous Coronary Intervention for Angina-Related Quality of Life in Patients With ST-Segment Elevation Myocardial Infarction Open
Importance In patients with multivessel coronary artery disease (CAD) presenting with ST-segment elevation myocardial infarction (STEMI), complete revascularization reduces major cardiovascular events compared with culprit lesion–only perc…
View article: Multi-vessel spontaneous coronary artery dissection in a patient with aortic dissection: a case report
Multi-vessel spontaneous coronary artery dissection in a patient with aortic dissection: a case report Open
Background Spontaneous coronary artery dissection (SCAD) is a rare cause of acute coronary syndrome that is often misdiagnosed. Case summary We describe a case of multi-vessel SCAD in a 73-year-old patient with no evidence of fibromuscular…
View article: Evaluation and management of chronic kidney disease patients with stable ischemic heart disease
Evaluation and management of chronic kidney disease patients with stable ischemic heart disease Open
View article: Transcatheter Aortic Valve Implantation in a Failed Perceval Sutureless Valve, Complicated by Aortic Annular Rupture
Transcatheter Aortic Valve Implantation in a Failed Perceval Sutureless Valve, Complicated by Aortic Annular Rupture Open
View article: Impact of prior oral anticoagulant use and outcomes on patients from secondary analysis in the AUGUSTUS trial
Impact of prior oral anticoagulant use and outcomes on patients from secondary analysis in the AUGUSTUS trial Open
Objective Managing antithrombotic therapy in patients with atrial fibrillation (AF) and an acute coronary syndrome (ACS) and/or percutaneous coronary intervention (PCI) is challenging and can be affected by prior oral anticoagulant (OAC) t…
View article: Long-Term Outcomes for Patients With Acute Coronary Syndrome and Nonvalvular Atrial Fibrillation
Long-Term Outcomes for Patients With Acute Coronary Syndrome and Nonvalvular Atrial Fibrillation Open
Short-term outcomes are worse for patients with acute coronary syndrome (ACS) with a history of nonvalvular atrial fibrillation (NVAF). However, long-term prognosis remains unclear. We linked administrative health databases to identify pat…
View article: Assessing the applicability and outcomes of the COMPASS trial a large cohort of atherosclerotic disease patients
Assessing the applicability and outcomes of the COMPASS trial a large cohort of atherosclerotic disease patients Open
Background Atherosclerotic Cardiovascular disease (ASCVD) is the leading cause of morbidity and mortality worldwide with substantial impact on health care resources. Rivaroxaban 2.5 mg twice daily with low dose ASA reduced death, myocardia…