Robert M. Cronin
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Persistent albuminuria and chronic kidney disease in adults with sickle cell anaemia: Results from a multicenter natural history study Open
Clinical and laboratory correlates of chronic kidney disease (CKD) in sickle cell anaemia remain incompletely defined. In a multicenter cohort study, we evaluated the prevalence of persistent albuminuria (PA) and characteristics associated…
Use of a Medical Communication Framework to Assess the Quality of Generative Artificial Intelligence Replies to Primary Care Patient Portal Messages: Content Analysis Open
Background There is growing interest in applying generative artificial intelligence (GenAI) to respond to electronic patient portal messages, particularly in primary care where message volumes are highest. However, evaluations of GenAI as …
View article: Usage of a Multipurpose mHealth App Among Adults With Sickle Cell Disease: Randomized Controlled Trial
Usage of a Multipurpose mHealth App Among Adults With Sickle Cell Disease: Randomized Controlled Trial Open
Background While mobile health (mHealth) apps have been made for various diseases, including sickle cell disease (SCD), most focus on a single purpose. SCD is a chronic disease that requires knowledge of the disease, self-management, and a…
Depression Screening and Primary Care Engagement and Their Association With Socioeconomic Disadvantage Among Adolescents Aged 13–17 Years With Sickle Cell Disease Open
It is unclear if adolescents with sickle cell disease (SCD) are screened for depression, since primary care provider (PCP) visits decline with age and socioeconomic disadvantage may impact receipt of care. This 1‐year study identified 97% …
Use of a Medical Communication Framework to Assess Quality of Automated Replies to Primary Care Portal Patient Messages: A Content Analysis. (Preprint) Open
BACKGROUND Generative artificial intelligence (GenAI) tools are increasingly available to assist clinicians in responding to patient messages; however, their suitability as a tool for medical communication in primary care has not been syst…
RAILS: A Synthetic Sampling Weights for Volunteer-Based National Biobanks -- A Case Study with the All of Us Research Program Open
While national biobanks are essential for advancing medical research, their non-probability sampling designs limit their representativeness of the target population. This paper proposes a method that leverages high-quality national surveys…
View article: Usage of a Multipurpose mHealth App among Adults with Sickle Cell Disease (Preprint)
Usage of a Multipurpose mHealth App among Adults with Sickle Cell Disease (Preprint) Open
BACKGROUND While mobile health applications (mHealth apps) have been made for various diseases, including sickle cell disease (SCD), most focus on a single purpose. SCD is a chronic disease that requires knowledge of the disease, self-mana…
Trends in Pregnancy Outcomes in People with Sickle Cell Disease and Medicaid Insurance (2006–2018) Open
Background: Although the risk of pregnancy-related morbidity and mortality in people with sickle cell disease (SCD) is well established, limitations in data sources and heterogeneity in outcome reporting hinder the ability to make meaningf…
View article: The use of abstract animations and a graphical body image for assessing pain outcomes among adults with sickle cell disease
The use of abstract animations and a graphical body image for assessing pain outcomes among adults with sickle cell disease Open
Painimation, a novel digital pain assessment tool, allows patients to communicate their pain quality, intensity, and location using abstract animations (painimations) and a paintable body image. This study determined the construct validity…
Improving follow-up survey completion rates through pilot interventions in the All of Us Research Program: Results from a non-randomized intervention study Open
Objective Retention to complete follow-up surveys in extensive longitudinal epidemiological cohort studies is vital yet challenging. All of Us developed pilot interventions to improve response rates for follow-up surveys. Study design and …
View article: Digital cognitive behavioral therapy vs education for pain in adults with sickle cell disease
Digital cognitive behavioral therapy vs education for pain in adults with sickle cell disease Open
Despite the burden of chronic pain in sickle cell disease (SCD), nonpharmacological approaches remain limited. This multisite, randomized trial compared digital cognitive behavioral therapy (CBT) with a digital pain/SCD education program (…
Balancing efficacy and computational burden: weighted mean, multiple imputation, and inverse probability weighting methods for item non-response in reliable scales Open
Importance Scales often arise from multi-item questionnaires, yet commonly face item non-response. Traditional solutions use weighted mean (WMean) from available responses, but potentially overlook missing data intricacies. Advanced method…
View article: Evaluating Self vs. Interviewer-Administered Screening for Anxiety in Sickle Cell Disease
Evaluating Self vs. Interviewer-Administered Screening for Anxiety in Sickle Cell Disease Open
Presentation Date: 6/9/2024 Presentation Start Time: 3:45:00 PM Background Sickle Cell Disease (SCD) is a group of inherited red blood cell disorders that affects approximately 100,000 adults in the United States alone. While most SCD rese…
View article: Measuring social determinants of health in the All of Us Research Program
Measuring social determinants of health in the All of Us Research Program Open
To accelerate medical breakthroughs, the All of Us Research Program aims to collect data from over one million participants. This report outlines processes used to construct the All of Us Social Determinants of Health (SDOH) survey and pre…
Burden of employment loss and absenteeism in adults and caregivers of children with sickle cell disease Open
Sickle cell disease (SCD) is a genetic disorder affecting 100 000 people with an estimated annual medical cost of $3 billion in the United States; however, the economic impact on patients is not well described. We aimed to examine the indi…
Mental health, pain and likelihood of opioid misuse among adults with sickle cell disease Open
Summary Depressive symptoms are prevalent in individuals living with sickle cell disease (SCD) and may exacerbate pain. This study examines whether higher depressive symptoms are associated with pain outcomes, pain catastrophizing, interfe…
View article: Comparing super-utilizers and lower-utilizers among commercial- and Medicare-insured adults with sickle cell disease
Comparing super-utilizers and lower-utilizers among commercial- and Medicare-insured adults with sickle cell disease Open
Sickle cell disease (SCD) is a rare but costly condition in the United States. Super-utilizers have been defined as a subset of the population with high health care encounters or expenditures. Although super-utilizers have been described i…
Predictive Capacity of Plasma and Urinary Biomarkers for Persistent Albuminuria in Patients with Sickle Cell Disease Open
Introduction: Chronic kidney disease (CKD) is common in sickle cell disease (SCD) and is associated with increased mortality and morbidity. As albuminuria and changes in estimated glomerular filtration rate (eGFR) occur well after substant…
Characterization of Sickle Cell Disease Mortality in a National Electronic Health Record (EHR) System Open
Introduction Sickle cell disease (SCD) is a chronic condition with significant morbidity in children and early adult mortality. Identifying high-risk SCD populations has been challenging due to limited population cohorts of children and ad…
View article: A feasibility randomized controlled trial of an mHealth app vs booklets for patient-facing guidelines in adults with SCD
A feasibility randomized controlled trial of an mHealth app vs booklets for patient-facing guidelines in adults with SCD Open
Despite the increased number of evidence-based guidelines for sickle cell disease (SCD), dissemination of evidence-based guidelines in lay language for individuals or families with SCD has not been evaluated. We conducted a feasibility ran…
Comparison of thromboembolism outcomes in patients with sickle cell disease prescribed hormonal contraception Open
Patients with sickle cell disease (SCD) are at a risk of thromboembolism (TE), and use of hormonal contraception can further increase that risk. This study aims to assess patterns of hormonal contraceptive use and compare risk of contracep…
The <i>All of Us</i> Data and Research Center: Creating a Secure, Scalable, and Sustainable Ecosystem for Biomedical Research Open
The All of Us Research Program's Data and Research Center (DRC) was established to help acquire, curate, and provide access to one of the world's largest and most diverse datasets for precision medicine research. Already, over 500,000 part…
Pregnancy‐related thromboembolism in women with sickle cell disease: An analysis of <span>National Medicaid Data</span> Open
Pregnancy and sickle cell disease (SCD) both individually carry a risk of thromboembolism (TE). Pregnancy in people with SCD may further enhance the prothrombotic effect of the underlying disease. The objectives of this study were to deter…
PB2516: ACTIGRAPHY IMPROVEMENT WITH VOXELOTOR (ACTIVE) STUDY: IMPACT OF VOXELOTOR ON PHYSICAL ACTIVITY, FATIGUE, AND SLEEP QUALITY Open
Topic: 26. Sickle cell disease Background: People with sickle cell disease (SCD) experience pain, sleep disturbance, poor sleep quality, fatigue, decreased exercise capacity, and decreased quality of life (QOL). Children with SCD are less …
View article: Measuring Social Determinants of Health in the<i>All of Us</i>Research Program: Technical Document
Measuring Social Determinants of Health in the<i>All of Us</i>Research Program: Technical Document Open
Background To advance precision medicine and improve population health, the All of Us Research Program aims to collect data, including a survey of social determinants of health (SDOH), from over 1 million participants. This report (1) outl…