Robert D. Burke
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View article: Ciliary photoreceptors in sea urchin larvae indicate pan-deuterostome cell type conservation
Ciliary photoreceptors in sea urchin larvae indicate pan-deuterostome cell type conservation Open
One of the signatures of evolutionarily related cell types is the expression of similar combinations of transcription factors in distantly related animals. Here we present evidence that sea urchin larvae possess bilateral clusters of cilia…
View article: Transforming a transcription factor
Transforming a transcription factor Open
A transcription factor that regulates skeleton formation in sea urchin embryos has evolved a new domain that is essential for this process.
View article: The sole LSm complex in <i>Cyanidioschyzon merolae</i> associates with pre-mRNA splicing and mRNA degradation factors
The sole LSm complex in <i>Cyanidioschyzon merolae</i> associates with pre-mRNA splicing and mRNA degradation factors Open
Proteins of the Sm and Sm-like (LSm) families, referred to collectively as (L)Sm proteins, are found in all three domains of life and are known to promote a variety of RNA processes such as base-pair formation, unwinding, RNA degradation, …
View article: Notch signaling patterns neurogenic ectoderm and regulates the asymmetric division of neural progenitors in sea urchin embryos
Notch signaling patterns neurogenic ectoderm and regulates the asymmetric division of neural progenitors in sea urchin embryos Open
We have examined regulation of neurogenesis by Delta/Notch signaling in sea urchin embryos. At gastrulation neural progenitors enter S-phase coincident with expression of Sp-SoxC. We used a BAC (bacterial artificial chromosome) containing …
View article: Eph and Ephrin function in dispersal and epithelial insertion of pigmented immunocytes in sea urchin embryos
Eph and Ephrin function in dispersal and epithelial insertion of pigmented immunocytes in sea urchin embryos Open
The mechanisms that underlie directional cell migration are incompletely understood. Eph receptors usually guide migrations of cells by exclusion from regions expressing Ephrin. In sea urchin embryos, pigmented immunocytes are specified in…
View article: Author response: Eph and Ephrin function in dispersal and epithelial insertion of pigmented immunocytes in sea urchin embryos
Author response: Eph and Ephrin function in dispersal and epithelial insertion of pigmented immunocytes in sea urchin embryos Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods References Decision letter Author response Article and author information Metrics Abstract The mechanisms that underlie directional cell m…
View article: Characterization of Calflagin, a Flagellar Calcium-Binding Protein from Trypanosoma congolense
Characterization of Calflagin, a Flagellar Calcium-Binding Protein from Trypanosoma congolense Open
While calflagin is conserved among different species of African trypanosomes, our results show that T. congolense calflagin possesses unique epitopes that differentiate this protein from homologues in other trypanosome species. MAb Tc6/42.…