Shu Ye
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View article: Sporoderm-removed ganoderma lucidum spore powder (S-GLSP) alleviates neuroinflammation injury by regulating microglial polarization through inhibition of NLRP3 inflammasome activation
Sporoderm-removed ganoderma lucidum spore powder (S-GLSP) alleviates neuroinflammation injury by regulating microglial polarization through inhibition of NLRP3 inflammasome activation Open
Introduction Sporoderm-Removed Ganoderma lucidum Spore Powder (S-GLSP), derived from the spores of the medically valued fungus Ganoderma lucidum, exhibits diverse pharmacological activities and shows considerable potential in the treatment…
View article: Dissecting the Cellular Genetics of Cardiovascular Disease Through Endothelial and Immune Compartments Profiling
Dissecting the Cellular Genetics of Cardiovascular Disease Through Endothelial and Immune Compartments Profiling Open
Background Non-communicable diseases such as coronary artery disease, atrial fibrillation, type 2 diabetes, hypertension, and others share endothelial dysfunction as one of their underlying features. The endothelium, as the interface betwe…
View article: Perioperative Medicine for Older People Undergoing Surgery Scale Up (POPS-SUp): study protocol
Perioperative Medicine for Older People Undergoing Surgery Scale Up (POPS-SUp): study protocol Open
Background Surgery provides definitive management of many age-related diseases, relieving symptoms or extending life. Age-related physiological decline, multimorbidity, and frailty predispose older people to postoperative complications and…
View article: The pan-NLRome and diversity of Watkins wheat provide genetic resources for improving disease resistance and adaptation
The pan-NLRome and diversity of Watkins wheat provide genetic resources for improving disease resistance and adaptation Open
The nucleotide-binding domain leucine-rich repeat (NLR) receptor proteins play pivotal roles in plant disease resistance due to their extensive genetic diversity driven by long-term co-evolution with pathogens. In this study, we present a …
View article: Genetic causality of circulating inflammatory proteins and plasma metabolites in coronary atherosclerosis
Genetic causality of circulating inflammatory proteins and plasma metabolites in coronary atherosclerosis Open
Background Coronary atherosclerosis is a leading cause of cardiovascular disease and death worldwide. Despite progress in understanding its pathogenesis, the roles of circulating inflammatory proteins and plasma metabolites are complex and…
View article: Artificial Intelligence in digital pathology of breast cancer, new era of practice?
Artificial Intelligence in digital pathology of breast cancer, new era of practice? Open
Breast cancer is the most common cancers among women worldwide. Early diagnosis and personalized medicine are crucial for the treatment of breast cancer. With the development of computer science and the emergence of whole slide imaging tec…
View article: O-070 NAD+ precursor nicotinamide mononucleotide improves the developmental competence of bovine embryos through enhancement of mitochondrial function in morula
O-070 NAD+ precursor nicotinamide mononucleotide improves the developmental competence of bovine embryos through enhancement of mitochondrial function in morula Open
Study question Does the addition of nicotinamide mononucleotide (NMN), an NAD+ precursor, to the culture medium of fertilized ovum increase their ability to develop into blastocysts? Summary answer The addition of NMN to the embryo culture…
View article: Salinity-induced virulence alteration of Aeromonas hydrophila isolated from Scatophagus argus: insights from transcriptomic profiling and phenotypic characterization
Salinity-induced virulence alteration of Aeromonas hydrophila isolated from Scatophagus argus: insights from transcriptomic profiling and phenotypic characterization Open
View article: Pan-cancer analysis reveal that m6A writer WTAP involve in tumor cell cycle regulation and tumor immunity
Pan-cancer analysis reveal that m6A writer WTAP involve in tumor cell cycle regulation and tumor immunity Open
View article: Clinical characteristics of botulinum toxin poisoning following cosmetic injections
Clinical characteristics of botulinum toxin poisoning following cosmetic injections Open
View article: Ultra-sensitive hydrogen sensor based on non-stoichiometric tin oxide heterojunction for LIBs thermal runaway early monitoring
Ultra-sensitive hydrogen sensor based on non-stoichiometric tin oxide heterojunction for LIBs thermal runaway early monitoring Open
View article: Conflict or Solidarity? A Cross-Cultural Study of Complaints in Mandarin Chinese and American English TV Series
Conflict or Solidarity? A Cross-Cultural Study of Complaints in Mandarin Chinese and American English TV Series Open
View article: Second edition of the joint international Cambridge-Antwerp Bioinformatics Hackathon
Second edition of the joint international Cambridge-Antwerp Bioinformatics Hackathon Open
View article: Indole derivatives and their associated microbial genera are associated with the 1-year changes in cardiometabolic risk markers in Chinese adults
Indole derivatives and their associated microbial genera are associated with the 1-year changes in cardiometabolic risk markers in Chinese adults Open
View article: 10033: Characterising DNAJC18's role in Heart Failure
10033: Characterising DNAJC18's role in Heart Failure Open
View article: Genetic influence on vascular smooth muscle cell apoptosis
Genetic influence on vascular smooth muscle cell apoptosis Open
View article: Network-based prioritization and validation of regulators of vascular smooth muscle cell proliferation in disease
Network-based prioritization and validation of regulators of vascular smooth muscle cell proliferation in disease Open
Aberrant vascular smooth muscle cell (VSMC) homeostasis and proliferation characterize vascular diseases causing heart attack and stroke. Here we elucidate molecular determinants governing VSMC proliferation by reconstructing gene regulato…
View article: Correction to: Chrysophanol exerts a protective effect against Aβ25‑35‑induced Alzheimer’s disease model through regulating the ROS/TXNIP/NLRP3 pathway
Correction to: Chrysophanol exerts a protective effect against Aβ25‑35‑induced Alzheimer’s disease model through regulating the ROS/TXNIP/NLRP3 pathway Open
View article: Crystal structure of diaqua-bis[1-(1-(hydroxymethyl)-1<i>H</i>-pyrazol-3-<i>yl</i>)-5-methyl-1<i>H</i>-1,2,3-triazole-4-carboxylato-<i>κ</i> <sup>2</sup> <i>N</i>,<i>O</i>)] manganese(II), C<sub>16</sub>H<sub>20</sub>MnN<sub>10</sub>O<sub>8</sub>
Crystal structure of diaqua-bis[1-(1-(hydroxymethyl)-1<i>H</i>-pyrazol-3-<i>yl</i>)-5-methyl-1<i>H</i>-1,2,3-triazole-4-carboxylato-<i>κ</i> <sup>2</sup> <i>N</i>,<i>O</i>)] manganese(II), C<sub>16</sub>H<sub>20</sub>MnN<sub>10</sub>O<sub>8</sub> Open
C 16 H 20 MnN 10 O 8 , monoclinic, P 2 1 / c (no. 14), a = 11.1178(7) Å, b = 12.7838(6) Å, c = 15.6649(10) Å, β = 105.692(6)°, V = 2143.4(2) Å 3 , Z = 4, R gt ( F ) = 0.0638, ωR ref ( F 2 ) = 0.2034, T = 293 K.
View article: Barriers to cascade screening in people at risk of Thoracic Aortic Disease: a mixed methods evaluation from the DECIDE-TAD initiative
Barriers to cascade screening in people at risk of Thoracic Aortic Disease: a mixed methods evaluation from the DECIDE-TAD initiative Open
Background Cascade genetic and imaging screening for relatives of people with non-syndromic thoracic aortic diseases (NS-TAD) is recommended by guidelines. However, the availability and uptake of cascade screening is low. The aim of this s…
View article: Systematic in vivo candidate evaluation uncovers therapeutic targets for LMNA dilated cardiomyopathy and risk of Lamin A toxicity
Systematic in vivo candidate evaluation uncovers therapeutic targets for LMNA dilated cardiomyopathy and risk of Lamin A toxicity Open
View article: Phenotypic Switching of Vascular Smooth Muscle Cells in Atherosclerosis
Phenotypic Switching of Vascular Smooth Muscle Cells in Atherosclerosis Open
The medial layer of the arterial wall is composed mainly of vascular smooth muscle cells (VSMCs). Under physiological conditions, VSMCs assume a contractile phenotype, and their primary function is to regulate vascular tone. In contrast wi…
View article: ELABELA/APJ Axis Prevents Diabetic Glomerular Endothelial Injury by Regulating AMPK/NLRP3 Pathway
ELABELA/APJ Axis Prevents Diabetic Glomerular Endothelial Injury by Regulating AMPK/NLRP3 Pathway Open
View article: Effector Genes at the Coronary Artery Disease Risk Locus Harboring <i>PDGFD</i> and LncRNA <i>AP002989.1</i>
Effector Genes at the Coronary Artery Disease Risk Locus Harboring <i>PDGFD</i> and LncRNA <i>AP002989.1</i> Open
View article: Effect of probiotic supplementation on in-hospital mortality in patients with acute myocardial infarction: a study protocol for an open-label, randomized, controlled, superiority clinical trial
Effect of probiotic supplementation on in-hospital mortality in patients with acute myocardial infarction: a study protocol for an open-label, randomized, controlled, superiority clinical trial Open
View article: Allele-Specific Epigenetic Regulation of FURIN Expression at a Coronary Artery Disease Susceptibility Locus
Allele-Specific Epigenetic Regulation of FURIN Expression at a Coronary Artery Disease Susceptibility Locus Open
Genome-wide association studies have revealed an association between the genetic variant rs17514846 in the FURIN gene and coronary artery disease. We investigated the mechanism through which rs17514846 modulates FURIN expression. An analys…
View article: Analysis of lncRNA and mRNA expression profiles in diabetic peripheral neuropathy based on weighted gene co-expression network analysis
Analysis of lncRNA and mRNA expression profiles in diabetic peripheral neuropathy based on weighted gene co-expression network analysis Open
Diabetic peripheral neuropathy (DPN) is a common complication of diabetes mellitus. Recent studies have explored the involvement of long non-coding RNA (lncRNA) in diabetes, but its specific role in DPN development remains unclear. To inve…
View article: A Novel Angiogenesis Role of GLP-1(32-36) to Rescue Diabetic Ischemic Lower Limbs via GLP-1R-Dependent Glycolysis
A Novel Angiogenesis Role of GLP-1(32-36) to Rescue Diabetic Ischemic Lower Limbs via GLP-1R-Dependent Glycolysis Open
Glucagon-like peptide 1 (GLP-1) improves angiogenesis, but the mechanism remains unclear. To address this question, we conducted a metabolomics analysis in bone marrow-derived endothelial progenitor cells (EPCs) isolated from T1DM mice tre…
View article: Allele-specific epigenetic regulation of<i>FURIN</i>expression at a coronary artery disease susceptibility locus
Allele-specific epigenetic regulation of<i>FURIN</i>expression at a coronary artery disease susceptibility locus Open
Background Genome-wide association studies have revealed an association between the genetic variant rs17514846 on chromosome 15q26.1 and coronary artery disease susceptibility. Studies have shown that rs17514846 influences the expression o…
View article: Supplementary Figure 1 from Association of <i>Matrix Metalloproteinase-8</i> Gene Variation with Breast Cancer Prognosis
Supplementary Figure 1 from Association of <i>Matrix Metalloproteinase-8</i> Gene Variation with Breast Cancer Prognosis Open
Supplementary Figure 1 from Association of Matrix Metalloproteinase-8 Gene Variation with Breast Cancer Prognosis