Robert Dallmann
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View article: Cationic Antimicrobial Copolymers Reveal Immunomodulatory Properties in Lipopolysaccharide Stimulated Macrophages <i>in Vitro</i>
Cationic Antimicrobial Copolymers Reveal Immunomodulatory Properties in Lipopolysaccharide Stimulated Macrophages <i>in Vitro</i> Open
Antimicrobial polymers, which have emerged as a promising alternative to antibiotics in the fight against antimicrobial resistance, are based on the design of cationic host defense peptides (CHDPs). Being part of the mammalian innate immun…
View article: Cyclic Peptide–Polymer Conjugate Nanotubes for Delivery of SN‐38 in Treatment of Colorectal Cancer Model
Cyclic Peptide–Polymer Conjugate Nanotubes for Delivery of SN‐38 in Treatment of Colorectal Cancer Model Open
Cyclic peptide‐polymer conjugate nanotubes have been shown to be powerful drug delivery vectors, due to their propensity for dynamic self‐assembly, high aspect ratio morphology and structural interchangeability. Building upon previous stud…
View article: Personalizing chronotherapy of immune checkpoint blockade
Personalizing chronotherapy of immune checkpoint blockade Open
Emerging evidence highlights the critical role of time-of-day (ToD) in immunotherapy, with large-scale retrospective studies showing that administering immune checkpoint inhibitors (ICIs) earlier in the day is associated with significantly…
View article: Machine learning assisted classification of cell and brain penetrating peptides
Machine learning assisted classification of cell and brain penetrating peptides Open
Crossing the blood–brain barrier (BBB) remains a major obstacle for central nervous system therapeutics. Short peptides have emerged as promising vectors, including cell-penetrating peptides (CPPs) and brain-penetrating peptides (BPPs). Ho…
View article: The cellular mammalian clock regulates <i>Staphylococcus aureus</i> invasion in epithelial cells
The cellular mammalian clock regulates <i>Staphylococcus aureus</i> invasion in epithelial cells Open
An endogenous biological clock, the circadian clock, coordinates life with the 24-hour day/night cycle of the environment. The unit of this circadian clock is the cell but in multicellular organisms, such as mammals, a circadian timing sys…
View article: Cyclopentadienyl Half‐Sandwich Rhodium(III) Azopyridine Anticancer Complexes with Activity Tuned by Ligand Substituents
Cyclopentadienyl Half‐Sandwich Rhodium(III) Azopyridine Anticancer Complexes with Activity Tuned by Ligand Substituents Open
We report the synthesis and characterization of ten novel half‐sandwich Rh(III) azopyridine complexes as potential anticancer agents, with the general formula [(η 5 ‐Cp x )Rh(4‐R 2 ‐phenylazopy‐5‐R 1 )Cl]PF 6 , where Cp x = Cp*, Cp xPh or …
View article: Cationic antimicrobial copolymers reveal immunomodulatory properties in LPS stimulated macrophages <i>in vitro</i>
Cationic antimicrobial copolymers reveal immunomodulatory properties in LPS stimulated macrophages <i>in vitro</i> Open
Antimicrobial polymers, which have emerged as a promising alternative to antibiotics in the fight against antimicrobial resistance, are based on the design of cationic host defence peptides (CHDPs). Being a part of the mammalian innate imm…
View article: Zinc finger homeobox-3 (ZFHX3) orchestrates genome-wide daily gene expression in the suprachiasmatic nucleus
Zinc finger homeobox-3 (ZFHX3) orchestrates genome-wide daily gene expression in the suprachiasmatic nucleus Open
The mammalian suprachiasmatic nucleus (SCN), situated in the ventral hypothalamus, directs daily cellular and physiological rhythms across the body. The SCN clockwork is a self-sustaining transcriptional-translational feedback loop (TTFL) …
View article: Zinc finger homeobox-3 (ZFHX3) orchestrates genome-wide daily gene expression in the suprachiasmatic nucleus
Zinc finger homeobox-3 (ZFHX3) orchestrates genome-wide daily gene expression in the suprachiasmatic nucleus Open
The mammalian suprachiasmatic nucleus (SCN), situated in the ventral hypothalamus, directs daily cellular and physiological rhythms across the body. The SCN clockwork is a self-sustaining transcriptional-translational feedback loop (TTFL) …
View article: Zinc finger homeobox-3 (ZFHX3) orchestrates genome-wide daily gene expression in the suprachiasmatic nucleus
Zinc finger homeobox-3 (ZFHX3) orchestrates genome-wide daily gene expression in the suprachiasmatic nucleus Open
The mammalian suprachiasmatic nucleus (SCN), situated in the ventral hypothalamus, directs daily cellular and physiological rhythms across the body. The SCN clockwork is a self-sustaining transcriptional-translational feedback loop (TTFL) …
View article: Zinc finger homeobox-3 (ZFHX3) orchestrates genome-wide daily gene expression in the suprachiasmatic nucleus
Zinc finger homeobox-3 (ZFHX3) orchestrates genome-wide daily gene expression in the suprachiasmatic nucleus Open
The mammalian suprachiasmatic nucleus (SCN), situated in the ventral hypothalamus, directs daily cellular and physiological rhythms across the body. The SCN clockwork is a self-sustaining transcriptional-translational feedback loop (TTFL) …
View article: TimeTeller: A tool to probe the circadian clock as a multigene dynamical system
TimeTeller: A tool to probe the circadian clock as a multigene dynamical system Open
Recent studies have established that the circadian clock influences onset, progression and therapeutic outcomes in a number of diseases including cancer and heart diseases. Therefore, there is a need for tools to measure the functional sta…
View article: Personalized Chronomodulated 5‐Fluorouracil Treatment: A Physiologically‐Based Pharmacokinetic Precision Dosing Approach for Optimizing Cancer Therapy
Personalized Chronomodulated 5‐Fluorouracil Treatment: A Physiologically‐Based Pharmacokinetic Precision Dosing Approach for Optimizing Cancer Therapy Open
The discovery of circadian clock genes greatly amplified the study of diurnal variations impacting cancer therapy, transforming it into a rapidly growing field of research. Especially, use of chronomodulated treatment with 5‐fluorouracil (…
View article: Tuning the photoactivated anticancer activity of Pt(<scp>iv</scp>) compounds <i>via</i> distant ferrocene conjugation
Tuning the photoactivated anticancer activity of Pt(<span>iv</span>) compounds <i>via</i> distant ferrocene conjugation Open
DFT calculations on a conjugate of ferrocene to an octahedral Pt( iv ) complex reveal Fe-to-Pt charge transfer, promoting longer-wavelength photoactivation, enhanced cellular accumulation, potent anticancer activity, and cell death via fer…
View article: Adenosine Kinase regulates Sleep Timing and the Homeostatic Sleep Response through Distinct Molecular Pathways
Adenosine Kinase regulates Sleep Timing and the Homeostatic Sleep Response through Distinct Molecular Pathways Open
Sleep behaviour is broadly regulated by two drives, the circadian (Process C), which is orchestrated by the suprachiasmatic nuclei (SCN), and controls sleep timing, and the homeostatic (Process S), which controls sleep amount and the respo…
View article: Zinc finger homeobox-3 (ZFHX3) orchestrates genome-wide daily gene expression in the suprachiasmatic nucleus
Zinc finger homeobox-3 (ZFHX3) orchestrates genome-wide daily gene expression in the suprachiasmatic nucleus Open
The mammalian suprachiasmatic nucleus (SCN), situated in the ventral hypothalamus, directs daily cellular and physiological rhythms across the body. The SCN clockwork is a self-sustaining transcriptional-translational feedback loop (TTFL) …
View article: CRH-R2 signalling modulates feeding and circadian gene expression in hypothalamic mHypoA-2/30 neurons
CRH-R2 signalling modulates feeding and circadian gene expression in hypothalamic mHypoA-2/30 neurons Open
The hypothalamic type 2 corticotropin releasing hormone receptor (CRH-R2) plays critical roles in homeostatic regulation, particularly in fine tuning stress recovery. During acute stress, the CRH-R2 ligands CRH and urocortins promote adapt…
View article: Correction to “Flow Rate-Independent Multiscale Liquid Biopsy for Precision Oncology”
Correction to “Flow Rate-Independent Multiscale Liquid Biopsy for Precision Oncology” Open
ADVERTISEMENT RETURN TO ARTICLES ASAPPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to "Flow Rate-Independent Multiscale Liquid Biopsy for Precision Oncology"Jie WangJie WangMore by Jie Wang, Robert Dallma…
View article: TimeTeller: a tool to probe the circadian clock as a multigene dynamical system
TimeTeller: a tool to probe the circadian clock as a multigene dynamical system Open
A bstract Recent studies have established that the circadian clock influences onset, progression and therapeutic outcomes in a number of diseases including cancer and heart diseases. Therefore, there is a need for tools to measure the func…
View article: Flow Rate-Independent Multiscale Liquid Biopsy for Precision Oncology
Flow Rate-Independent Multiscale Liquid Biopsy for Precision Oncology Open
Immunoaffinity-based liquid biopsies of circulating tumor cells (CTCs) hold great promise for cancer management but typically suffer from low throughput, relative complexity, and postprocessing limitations. Here, we address these issues si…
View article: Sleep and circadian rhythm disruption alters the lung transcriptome to predispose to viral infection
Sleep and circadian rhythm disruption alters the lung transcriptome to predispose to viral infection Open
Sleep and circadian rhythm disruption (SCRD), as encountered during shift work, increases the risk of respiratory viral infection including SARS-CoV-2. However, the mechanism(s) underpinning higher rates of respiratory viral infection foll…
View article: NQO1 protects against clioquinol toxicity
NQO1 protects against clioquinol toxicity Open
Clioquinol (CQ) was widely used as oral antibiotic before being taken off the market in many countries in 1970, after it was linked to subacute myelo-optic neuropathy (SMON) in Japan, leading to vision loss with many patients left wheelcha…
View article: Probing the Effect of Rigidity on the Cellular Uptake of Core‐Shell Nanoparticles: Stiffness Effects are Size Dependent
Probing the Effect of Rigidity on the Cellular Uptake of Core‐Shell Nanoparticles: Stiffness Effects are Size Dependent Open
Nanoparticles are well established vectors for the delivery of a wide range of biomedically relevant cargoes. Numerous studies have investigated the impact of size, shape, charge, and surface functionality of nanoparticles on mammalian cel…
View article: Flow Rate Independent Multiscale Liquid Biopsy for Precision Oncology
Flow Rate Independent Multiscale Liquid Biopsy for Precision Oncology Open
Immunoaffinity-based liquid biopsies of circulating tumor cells (CTCs) hold great promise for cancer management, but typically suffer from low throughput, relative complexity and post-processing limitations. Here we address these issues si…
View article: Renal Transporter‐Mediated Drug‐Biomarker Interactions of the Endogenous Substrates Creatinine and N<sup>1</sup>‐Methylnicotinamide: A PBPK Modeling Approach
Renal Transporter‐Mediated Drug‐Biomarker Interactions of the Endogenous Substrates Creatinine and N<sup>1</sup>‐Methylnicotinamide: A PBPK Modeling Approach Open
Endogenous biomarkers for transporter‐mediated drug‐drug interaction (DDI) predictions represent a promising approach to facilitate and improve conventional DDI investigations in clinical studies. This approach requires high sensitivity an…
View article: Sleep and circadian rhythm disruption alters the lung transcriptome to predispose to viral infection
Sleep and circadian rhythm disruption alters the lung transcriptome to predispose to viral infection Open
Sleep and circadian rhythm disruption (SCRD), as encountered during shift work, increases the risk of respiratory viral infection including SARS-CoV-2. However, the mechanism(s) underpinning higher rates of respiratory viral infection foll…
View article: Cell-Type-Specific Circadian Bioluminescence Rhythms in <i>Dbp</i> Reporter Mice
Cell-Type-Specific Circadian Bioluminescence Rhythms in <i>Dbp</i> Reporter Mice Open
Circadian rhythms are endogenously generated physiological and molecular rhythms with a cycle length of about 24 h. Bioluminescent reporters have been exceptionally useful for studying circadian rhythms in numerous species. Here, we report…