Robert Dawe
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View article: Testing patterns, patient and tumour characteristics and survival by NRAS and KIT genotype in melanoma
Testing patterns, patient and tumour characteristics and survival by NRAS and KIT genotype in melanoma Open
Background NRAS and KIT mutations in melanoma bring implications for prognosis, follow-up, selection into trials and potential future treatment with targeted therapies. The frequency of NRAS/KIT mutations and their association with patient…
View article: Cord blood porphyrin analysis in neonates at risk of inheriting protoporphyria: An observational cohort study
Cord blood porphyrin analysis in neonates at risk of inheriting protoporphyria: An observational cohort study Open
Research letter to the editor
View article: PD07 Polymorphic light eruption: insights from a tertiary photodiagnostic service
PD07 Polymorphic light eruption: insights from a tertiary photodiagnostic service Open
Polymorphic light eruption (PLE) is the most common photodermatosis. It is typically characterized by seasonal delayed-onset induction of rash of variable morphology after sunlight exposure. This study investigated the demographic, clinica…
View article: PD13 Refractory inflammatory dermatoses: 17 years’ British grenz ray experience
PD13 Refractory inflammatory dermatoses: 17 years’ British grenz ray experience Open
Grenz ray therapy is a type of ultrasoft X-ray therapy used since 1923. In our centre, treatment is usually weekly, with dose per treatment varying according to indication and other factors (such as hair thickness if treating the scalp). T…
View article: PD03 Normal erythema ranges in diagnostic phototesting
PD03 Normal erythema ranges in diagnostic phototesting Open
In diagnostic phototesting there are only a few published reference ranges for nonphotosensitive populations. These ranges are specific to the population being investigated and are dependent upon the equipment used. We wished to explore wh…
View article: DE06 Harnessing active in-depth learning for students and residents through a competitive card game: ‘Skin Stacks: Dermatology Therapeutics’
DE06 Harnessing active in-depth learning for students and residents through a competitive card game: ‘Skin Stacks: Dermatology Therapeutics’ Open
We reflected on feedback from medical students on how lecture-based teaching did not stimulate active learning or the characteristics of in-depth learning. We utilized a competitive two-player category-based card game (inspired by existing…
View article: DS18 Living with dermatofibrosarcoma protuberans: patients’ perspectives on health-related quality-of-life measures
DS18 Living with dermatofibrosarcoma protuberans: patients’ perspectives on health-related quality-of-life measures Open
Dermatofibrosarcoma protuberans (DFSP) is a rare, indolent, locally invasive soft-tissue sarcoma with low tumour-related mortality. Despite its favourable prognosis, patients with DFSP may experience a high degree of surgical-related morbi…
View article: An investigation into eye protection for patients receiving oral psoralen photochemotherapy (PUVA)
An investigation into eye protection for patients receiving oral psoralen photochemotherapy (PUVA) Open
This study investigates the effectiveness of ultraviolet (UV) protection provided by various types of glasses for patients who have orally ingested psoralen. Psoralen is administered orally by patients, as part of PUVA photochemotherapy, 2…
View article: Topical Photodynamic Therapy in a Medical Centre: The Scottish Dermatology Experience
Topical Photodynamic Therapy in a Medical Centre: The Scottish Dermatology Experience Open
Background Topical photodynamic therapy (PDT) is widely used in dermatology for treating superficial non‐melanoma skin cancer (NMSC) and dysplasia. This study aims to assess real‐world outcomes of PDT in a Scottish dermatology service. Met…
View article: O01 Survey of Scottish Dermatology Society members on the new Medicines and Healthcare products Regulatory Agency isotretinoin recommendations
O01 Survey of Scottish Dermatology Society members on the new Medicines and Healthcare products Regulatory Agency isotretinoin recommendations Open
Recent Medicines and Healthcare products Regulatory Agency (MHRA) isotretinoin legislation includes significant changes that will affect clinical practice (Medicines and Healthcare products Regulatory Agency. Drug Safety Update volume 16, …
View article: DE05 (P046) The hidden generic curriculum: identifying and formalizing important soft skills for trainee dermatologists. A retrospective review of journal club experience (2022–2023)
DE05 (P046) The hidden generic curriculum: identifying and formalizing important soft skills for trainee dermatologists. A retrospective review of journal club experience (2022–2023) Open
We identified important soft skills not specifically highlighted within the dermatology trainee Joint Royal Colleges of Physicians Training Board (JRCPTB) curriculum, from our journal club experience. We propose a ‘hidden generic curriculu…
View article: P046 The hidden generic curriculum: identifying and formalizing important soft skills for trainee dermatologists. A retrospective review of journal club experience (2022–2023)
P046 The hidden generic curriculum: identifying and formalizing important soft skills for trainee dermatologists. A retrospective review of journal club experience (2022–2023) Open
We identified important soft skills not specifically highlighted within the dermatology trainee Joint Royal Colleges of Physicians Training Board (JRCPTB) curriculum, from our journal club experience. We propose a ‘hidden generic curriculu…
View article: Dupilumab in chronic actinic dermatitis: a retrospective case series
Dupilumab in chronic actinic dermatitis: a retrospective case series Open
We report a retrospective case series from two UK photobiology units of 12 patients with concomitant atopic dermatitis (AD) and chronic actinic dermatitis (CAD) treated with dupilumab as a systemic monotherapy. While dupilumab is an effect…
View article: Erythropoietic protoporphyria and afamelanotide: a patient’s perspective
Erythropoietic protoporphyria and afamelanotide: a patient’s perspective Open
The patient explores the profound impact of erythropoietic protoporphyria (EPP) on her life to date. The clinician’s comment reviews the symptoms and diagnostic criteria for EPP, as well as the novel treatment afamelanotide for EPP.
View article: PD06 Efficacy of dupilumab in chronic actinic dermatitis
PD06 Efficacy of dupilumab in chronic actinic dermatitis Open
Chronic actinic dermatitis (CAD) is characterized by a photoexposed site dermatitis in association with objective evidence of photosensitivity, often arising on a background of atopic dermatitis (AD). Dupilumab is a monoclonal antibody tha…
View article: Supplemental Figures S1-9 from Nrf2 Activation Protects against Solar-Simulated Ultraviolet Radiation in Mice and Humans
Supplemental Figures S1-9 from Nrf2 Activation Protects against Solar-Simulated Ultraviolet Radiation in Mice and Humans Open
Supplemental Figure S1. Spectral characteristics of UVA 340 lamps. Figure S2. Nrf2 disruption leads to an increase in the mRNA of Nrf3, but not Nrf1, in skin of SKH-1 hairless mice. Figure S3. TBE-31 treatment induces NQO1 in dermis and ep…
View article: Supplemental Methods, Results, Figure Legend from Nrf2 Activation Protects against Solar-Simulated Ultraviolet Radiation in Mice and Humans
Supplemental Methods, Results, Figure Legend from Nrf2 Activation Protects against Solar-Simulated Ultraviolet Radiation in Mice and Humans Open
Supplemental Methods, Results, Figure Legend
View article: Supplemental Methods, Results, Figure Legend from Nrf2 Activation Protects against Solar-Simulated Ultraviolet Radiation in Mice and Humans
Supplemental Methods, Results, Figure Legend from Nrf2 Activation Protects against Solar-Simulated Ultraviolet Radiation in Mice and Humans Open
Supplemental Methods, Results, Figure Legend
View article: Data from Nrf2 Activation Protects against Solar-Simulated Ultraviolet Radiation in Mice and Humans
Data from Nrf2 Activation Protects against Solar-Simulated Ultraviolet Radiation in Mice and Humans Open
The transcription factor Nrf2 determines the ability to adapt and survive under conditions of electrophilic, oxidative, and inflammatory stress by regulating the expression of elaborate networks comprising nearly 500 genes encoding protein…
View article: Data from Nrf2 Activation Protects against Solar-Simulated Ultraviolet Radiation in Mice and Humans
Data from Nrf2 Activation Protects against Solar-Simulated Ultraviolet Radiation in Mice and Humans Open
The transcription factor Nrf2 determines the ability to adapt and survive under conditions of electrophilic, oxidative, and inflammatory stress by regulating the expression of elaborate networks comprising nearly 500 genes encoding protein…
View article: Supplemental Figures S1-9 from Nrf2 Activation Protects against Solar-Simulated Ultraviolet Radiation in Mice and Humans
Supplemental Figures S1-9 from Nrf2 Activation Protects against Solar-Simulated Ultraviolet Radiation in Mice and Humans Open
Supplemental Figure S1. Spectral characteristics of UVA 340 lamps. Figure S2. Nrf2 disruption leads to an increase in the mRNA of Nrf3, but not Nrf1, in skin of SKH-1 hairless mice. Figure S3. TBE-31 treatment induces NQO1 in dermis and ep…
View article: Commercial visible-light protecting sunscreens for photosensitive individuals
Commercial visible-light protecting sunscreens for photosensitive individuals Open
Visible light sensitivity can have a severe adverse impact on quality of life leading to withdrawal from social activity during daylight hours. Treatment options are limited and expensive. Commercially available sunscreens that provide vis…
View article: British Association of Dermatologists and British Photodermatology Group guidelines for narrowband ultraviolet B phototherapy 2022
British Association of Dermatologists and British Photodermatology Group guidelines for narrowband ultraviolet B phototherapy 2022 Open
Linked Comment: P. Wolf. Br J Dermatol 2022; 187:285–286.
View article: Issue Information
Issue Information Open
Position statement on practical management of epidermolysis bullosaAmoxicillin-induced DRESS (drug reaction with eosinophilia and systemic symptoms) Quality of life in mycosis fungoides
View article: A randomized assessor‐blinded comparison of low‐irradiance and conventional‐irradiance photodynamic therapy for superficial basal cell carcinoma and Bowen disease
A randomized assessor‐blinded comparison of low‐irradiance and conventional‐irradiance photodynamic therapy for superficial basal cell carcinoma and Bowen disease Open
The inconvenience and pain of hospital-based photodynamic therapy (PDT) is sometimes limiting.1 We developed very low irradiance LEDs for ambulatory PDT. Preliminary studies showed this to be convenient and relatively painless.1-4 Here we …