Robert Dürr
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View article: Pore Network Model for Study of Biofilm Growth Limitations in Porous Substrata
Pore Network Model for Study of Biofilm Growth Limitations in Porous Substrata Open
We present a pore network approach for the simulation and study of biofilm growth inside porous structures under various limiting conditions. The proposed pore-scale model allows us to resolve the interrelationship between growth and diffu…
View article: Finite difference physics-informed neural networks enable improved solution accuracy of the Navier-Stokes equations
Finite difference physics-informed neural networks enable improved solution accuracy of the Navier-Stokes equations Open
Generating an accurate solution of the Navier--Stokes equations using physics--informed neural networks (PINNs) for higher Reynolds numbers in the corners of a lid--driven cavity problem is challenging. In this paper, we improve the soluti…
View article: Stability of Combined Continuous Granulation and Agglomeration Processes in a Fluidized Bed with Sieve-Mill-Recycle
Stability of Combined Continuous Granulation and Agglomeration Processes in a Fluidized Bed with Sieve-Mill-Recycle Open
Particle formation in fluidized beds is widely applied in an industrial context for the solidification of liquids and size enlargement of granular materials. The two main size-enlargement mechanisms are layering growth and agglomeration. F…
View article: Multiscale modeling of the microbial production of polyhydroxyalkanoates using two carbon sources
Multiscale modeling of the microbial production of polyhydroxyalkanoates using two carbon sources Open
Polyhydroxyalkanoates are a promising material for a broad range of plastic products. Due to the high production costs, the proportion of industrial produced polyhydroxyalkanoates is low compared to conventional plastics. One possibility t…
View article: Discrepancy-based control of particle processes
Discrepancy-based control of particle processes Open
The production of goods in particulate form is important in many industries such as the chemical, pharmaceutical and food industry. For the subsequent use, specific particle properties determine the quality of the product. In order to ensu…
View article: Multi-Rate Data Fusion for State and Parameter Estimation in (Bio-)Chemical Process Engineering
Multi-Rate Data Fusion for State and Parameter Estimation in (Bio-)Chemical Process Engineering Open
For efficient operation, modern control approaches for biochemical process engineering require information on the states of the process such as temperature, humidity or chemical composition. Those measurement are gathered from a set of sen…
View article: Process Behavior and Product Quality in Fertilizer Manufacturing Using Continuous Hopper Transfer Pan Granulation—Experimental Investigations
Process Behavior and Product Quality in Fertilizer Manufacturing Using Continuous Hopper Transfer Pan Granulation—Experimental Investigations Open
Fertilizers are commonly used to improve the soil quality in both conventional and organic agriculture. One such fertilizer is dolomite for which soil application in granulated form is advantageous. These granules are commonly produced fro…
View article: Discrepancy-based Control of Particle Processes
Discrepancy-based Control of Particle Processes Open
The production of goods in particulate form is important in many industries such as the chemical, pharmaceutical and food industry. For the subsequent use, specific particle properties determine the quality of the product. In order toensur…
View article: Advanced Kinetic Modeling of Bio-co-polymer Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) Production Using Fructose and Propionate as Carbon Sources
Advanced Kinetic Modeling of Bio-co-polymer Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) Production Using Fructose and Propionate as Carbon Sources Open
Biopolymers are a promising alternative to petroleum-based plastic raw materials. They are bio-based, non-toxic and degradable under environmental conditions. In addition to the homopolymer poly(3-hydroxybutyrate) (PHB), there are a number…
View article: Advanced Kinetic Modeling of Bio-co-polymer Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) Production using Fructose and Propionate as Carbon Sources
Advanced Kinetic Modeling of Bio-co-polymer Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) Production using Fructose and Propionate as Carbon Sources Open
Biopolymers are a promising alternative to petroleum-based plastic raw material. They are bio-based, non-toxic and degradable under environmental conditions. In addition to the homopolymer poly-3-hydroxybutyrate (PHB), there are a number o…
View article: Kernel identification in continuous fluidized bed spray agglomeration from steady state data
Kernel identification in continuous fluidized bed spray agglomeration from steady state data Open
Fluidized bed spray agglomeration is an important industrial particle formation process. In particular, the continuous operation mode is able to provide a constant stream of product particles with constant quality in terms of particle prop…
View article: Control of Particle Formation Processes
Control of Particle Formation Processes Open
Discrepancy-based control (DBC) represents an elegant direct control design concept for infinite-dimensional systems, which is frequently used to control particle formation processes, an important class of operations in chemical engineerin…
View article: Computational Optimization of Porous Structures for Electrochemical Processes
Computational Optimization of Porous Structures for Electrochemical Processes Open
Porous structures are naturally involved in electrochemical processes. The specific architectures of the available porous materials, as well as their physical properties, crucially affect their applications, e.g., their use in fuel cells, …
View article: Model-based approach for predicting the impact of genetic modifications on product yield in biopharmaceutical manufacturing—Application to influenza vaccine production
Model-based approach for predicting the impact of genetic modifications on product yield in biopharmaceutical manufacturing—Application to influenza vaccine production Open
A large group of biopharmaceuticals is produced in cell lines. The yield of such products can be increased by genetic engineering of the corresponding cell lines. The prediction of promising genetic modifications by mathematical modeling i…
View article: Approximate Moment Methods for Population Balance Equations in Particulate and Bioengineering Processes
Approximate Moment Methods for Population Balance Equations in Particulate and Bioengineering Processes Open
Population balance modeling is an established framework to describe the dynamics of particle populations in disperse phase systems found in a broad field of industrial, civil, and medical applications. The resulting population balance equa…
View article: Hybrid Cybernetic Modeling of Polyhydroxyalkanoate Production in Cupriavidus necator using Fructose and Acetate as Substrates
Hybrid Cybernetic Modeling of Polyhydroxyalkanoate Production in Cupriavidus necator using Fructose and Acetate as Substrates Open
Due to their advantageous properties, polyhydroxyalkanoates are a promising alternative to conventional petroleum-based plastics. Currently, high production costs in upstream and downstream have to be reduced to make the plastic material c…
View article: Inferential control of product properties for fluidized bed spray granulation layering
Inferential control of product properties for fluidized bed spray granulation layering Open
Fluidized bed layering granulation has found application in a wide range of industrial processes, e.g. food, pharmaceutical or fertilizer manufacturing. The quality of the produced granules is a critical factor for subsequent processing st…
View article: Lyapunov-based online parameter estimation in continuous fluidized bed spray agglomeration processes
Lyapunov-based online parameter estimation in continuous fluidized bed spray agglomeration processes Open
Fluidized bed spray agglomeration is a particle formation process in many industrial applications, e.g. pharmaceutical and food processing. The properties of the formed agglomerates, like characteristic volume, significantly affect the pro…
View article: Parameter Identification For Continuous Fluidized Bed Spray Agglomeration
Parameter Identification For Continuous Fluidized Bed Spray Agglomeration Open
Agglomeration represents an important particle formation process used in many industries. One particularly attractive process setup is continuous fluidized bed spray agglomeration, which features good mixing as well as high heat and mass t…
View article: A Novel Framework for Parameter and State Estimation of Multicellular Systems Using Gaussian Mixture Approximations
A Novel Framework for Parameter and State Estimation of Multicellular Systems Using Gaussian Mixture Approximations Open
Multicellular systems play an important role in many biotechnological processes. Typically, these exhibit cell-to-cell variability, which has to be monitored closely for process control and optimization. However, some properties may not be…
View article: Robust feedback control of continuously operated convective dryers for particulate materials
Robust feedback control of continuously operated convective dryers for particulate materials Open
Convective drying is a common process for the treatment of particulate solids also operated in continuous mode. Continuous operation is characterised by operation in steady-state with constant product throughput and constant product qualit…
View article: Hybrid simulation algorithm for efficient numerical solution of population balance equations
Hybrid simulation algorithm for efficient numerical solution of population balance equations Open
Cell-to-cell variability of multicellular systems affects many processes from biopro- cess engineering, systems biology and systems medicine. Multiscale modeling of these cellular heterogeneities with population balance equations is a valu…
View article: Mathematical modeling as a tool to improve influenza vaccine production processes
Mathematical modeling as a tool to improve influenza vaccine production processes Open
Cell culture-based production of influenza vaccines is emerging as a promising alternative to conventional production in embryonated chicken eggs. Development and establishment of high-yield producer cell lines represents a major challenge…
View article: Modeling and Simulation of Particulate Processes.
Modeling and Simulation of Particulate Processes. Open
Particulate processes can be modeled by means of populations balances. This is an important class of nonlinear partial differential equations with many applications in chemical and biochemical engineering. Major challenges are multidimensi…
View article: Analyzing the Impact of Heterogeneity in Genetically Engineered Cell Lines for Influenza Vaccine Production Using Population Balance Modeling
Analyzing the Impact of Heterogeneity in Genetically Engineered Cell Lines for Influenza Vaccine Production Using Population Balance Modeling Open
Engineering of novel cell lines for biotechnological processes, e.g. influenza virus vaccine production, can be achieved by the genetic modification of host cell gene expression. Therefore, versatile genome editing methods such as lentivir…