Robert Dyrdak
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View article: The effect of remdesivir and nirmatrelvir/ritonavir on mortality in patients hospitalized with COVID-19 during the Omicron era: an emulated target trial
The effect of remdesivir and nirmatrelvir/ritonavir on mortality in patients hospitalized with COVID-19 during the Omicron era: an emulated target trial Open
Treatment with remdesivir and/or nirmatrelvir/ritonavir was associated with reduced mortality in hospitalized SARS-CoV-2-infected patients during the Omicron era, primarily in unvaccinated individuals without previous infection. Our findin…
View article: Epidemiological and Clinical Insights into Enterovirus Circulation in Europe, 2018–2023: A Multicenter Retrospective Surveillance Study
Epidemiological and Clinical Insights into Enterovirus Circulation in Europe, 2018–2023: A Multicenter Retrospective Surveillance Study Open
Background Enteroviruses (EV) cause yearly outbreaks with severe infections, particularly in young children. This study investigates EV circulation, age, and clinical presentations in Europe from 2018 to 2023. Methods Aggregated data were …
View article: Early unrecognised SARS-CoV-2 introductions shaped the first pandemic wave, Sweden, 2020
Early unrecognised SARS-CoV-2 introductions shaped the first pandemic wave, Sweden, 2020 Open
Background Despite the unprecedented measures implemented globally in early 2020 to prevent the spread of SARS-CoV-2, Sweden, as many other countries, experienced a severe first wave during the COVID-19 pandemic. Aim We investigated the in…
View article: Epidemiological and Clinical Insights into the Enterovirus D68 Upsurge in Europe 2021–2022 and Emergence of Novel B3-Derived Lineages, ENPEN Multicentre Study
Epidemiological and Clinical Insights into the Enterovirus D68 Upsurge in Europe 2021–2022 and Emergence of Novel B3-Derived Lineages, ENPEN Multicentre Study Open
Enterovirus D68 (EV-D68) infections are associated with severe respiratory disease and acute flaccid myelitis (AFM). The European Non-Polio Enterovirus Network (ENPEN) aimed to investigate the epidemiological and genetic characteristics of…
View article: Functional SARS-CoV-2 cross-reactive CD4 <sup>+</sup> T cells established in early childhood decline with age
Functional SARS-CoV-2 cross-reactive CD4 <sup>+</sup> T cells established in early childhood decline with age Open
Pre-existing SARS-CoV-2-reactive T cells have been identified in SARS-CoV-2-unexposed individuals, potentially modulating COVID-19 and vaccination outcomes. Here, we provide evidence that functional cross-reactive memory CD4 + T cell immun…
View article: Surveillance of tick-borne encephalitis in emerging risk areas in southern Sweden: a retrospective case finding study
Surveillance of tick-borne encephalitis in emerging risk areas in southern Sweden: a retrospective case finding study Open
Tick-borne encephalitis (TBE) is an emerging infection causing CNS infection of various severity. Good knowledge of the incidence in the population and defined risk areas is important in risk communication and vaccination recommendations. …
View article: Evolution, geographic spreading, and demographic distribution of Enterovirus D68
Evolution, geographic spreading, and demographic distribution of Enterovirus D68 Open
Worldwide outbreaks of enterovirus D68 (EV-D68) in 2014 and 2016 have caused serious respiratory and neurological disease. We collected samples from several European countries during the 2018 outbreak and determined 53 near full-length gen…
View article: Structural basis of Omicron neutralization by affinity-matured public antibodies
Structural basis of Omicron neutralization by affinity-matured public antibodies Open
The SARS-CoV-2 Omicron 1 Variant of Concern (B.1.1.529) has spread rapidly in many countries. With a spike that is highly diverged from that of the pandemic founder, it escapes most available monoclonal antibody therapeutics 2,3 and erodes…
View article: Re-emergence of enterovirus D68 in Europe after easing the COVID-19 lockdown, September 2021
Re-emergence of enterovirus D68 in Europe after easing the COVID-19 lockdown, September 2021 Open
We report a rapid increase in enterovirus D68 (EV-D68) infections, with 139 cases reported from eight European countries between 31 July and 14 October 2021. This upsurge is in line with the seasonality of EV-D68 and was presumably stimula…
View article: Clinical phenotypes and outcomes of SARS-CoV-2, influenza, RSV and seven other respiratory viruses: a retrospective study using complete hospital data
Clinical phenotypes and outcomes of SARS-CoV-2, influenza, RSV and seven other respiratory viruses: a retrospective study using complete hospital data Open
Background An understanding of differences in clinical phenotypes and outcomes COVID-19 compared with other respiratory viral infections is important to optimise the management of patients and plan healthcare. Herein we sought to investiga…
View article: Molecular Epidemiology and Evolutionary Trajectory of Emerging Echovirus 30, Europe
Molecular Epidemiology and Evolutionary Trajectory of Emerging Echovirus 30, Europe Open
In 2018, an upsurge in echovirus 30 (E30) infections was reported in Europe. We conducted a large-scale epidemiologic and evolutionary study of 1,329 E30 strains collected in 22 countries in Europe during 2016-2018. Most E30 cases affected…
View article: Molecular Epidemiology and Evolutionary Trajectory of Emerging Echovirus 30, Europe
Molecular Epidemiology and Evolutionary Trajectory of Emerging Echovirus 30, Europe Open
In 2018, an upsurge in echovirus 30 (E30) infections was reported in Europe. We conducted a large-scale epidemiologic and evolutionary study of 1,329 E30 strains collected in 22 countries in Europe during 2016–2018. Most E30 cases affected…
View article: Interactions between seasonal human coronaviruses and implications for the SARS-CoV-2 pandemic: A retrospective study in Stockholm, Sweden, 2009-2020
Interactions between seasonal human coronaviruses and implications for the SARS-CoV-2 pandemic: A retrospective study in Stockholm, Sweden, 2009-2020 Open
Objectives The four seasonal coronaviruses 229E, NL63, OC43, and HKU1 are frequent causes of respiratory infections and show annual and seasonal variation. Increased understanding about these patterns could be informative about the epidemi…
View article: Potential impact of seasonal forcing on a SARS-CoV-2 pandemic
Potential impact of seasonal forcing on a SARS-CoV-2 pandemic Open
A novel coronavirus (SARS-CoV-2) first detected in Wuhan, China, has spread rapidly since December 2019, causing more than 100,000 confirmed infections and 4000 fatalities (as of 10 March 2020). The outbreak has been declared a pandemic by…
View article: Potential impact of seasonal forcing on a SARS-CoV-2 pandemic
Potential impact of seasonal forcing on a SARS-CoV-2 pandemic Open
A novel coronavirus (SARS-CoV-2) first detected in Wuhan, China, has spread rapidly since December 2019, causing more than 80,000 confirmed infections and 2,700 fatalities (as of Feb 27, 2020). Imported cases and transmission clusters of v…
View article: Evolution, geographic spreading, and demographic distribution of Enterovirus D68
Evolution, geographic spreading, and demographic distribution of Enterovirus D68 Open
Background Worldwide outbreaks of enterovirus D68 (EV-D68) in 2014 and 2016 have caused serious respiratory and neurological disease. Methods We collected samples from several European countries during the 2018 out-break and determined 53 …
View article: Co-circulation of multiple enterovirus D68 subclades, including a novel B3 cluster, across Europe in a season of expected low prevalence, 2019/20
Co-circulation of multiple enterovirus D68 subclades, including a novel B3 cluster, across Europe in a season of expected low prevalence, 2019/20 Open
Enterovirus D68 (EV-D68) was detected in 93 patients from five European countries between 1 January 2019 and 15 January 2020, a season with expected low circulation. Patients were primarily children (n = 67, median age: 4 years), 59 patien…
View article: A European multicentre evaluation of detection and typing methods for human enteroviruses and parechoviruses using RNA transcripts
A European multicentre evaluation of detection and typing methods for human enteroviruses and parechoviruses using RNA transcripts Open
Polymerase chain reaction (PCR) detection has become the gold standard for diagnosis and typing of enterovirus (EV) and human parechovirus (HPeV) infections. Its effectiveness depends critically on using the appropriate sample types and hi…
View article: A European multicentre evaluation of detection and typing methods for human enteroviruses and parechoviruses using RNA transcripts
A European multicentre evaluation of detection and typing methods for human enteroviruses and parechoviruses using RNA transcripts Open
Polymerase chain reaction (PCR) detection has become the gold standard for diagnosis and typing of enterovirus (EV) and human parechovirus (HPeV) infections. Its effectiveness depends critically on using the appropriate sample types and hi…
View article: Intra- and interpatient evolution of enterovirus D68 analyzed by whole-genome deep sequencing
Intra- and interpatient evolution of enterovirus D68 analyzed by whole-genome deep sequencing Open
Worldwide outbreaks of enterovirus D68 (EV-D68) in 2014 and 2016 have caused serious respiratory and neurological disease. To investigate diversity, spread, and evolution of EV-D68 we performed near full-length deep sequencing in fifty-fou…
View article: Recommendations for enterovirus diagnostics and characterisation within and beyond Europe
Recommendations for enterovirus diagnostics and characterisation within and beyond Europe Open
Enteroviruses (EV) can cause severe neurological and respiratory infections, and occasionally lead to devastating outbreaks as previously demonstrated with EV-A71 and EV-D68 in Europe. However, these infections are still often underdiagnos…
View article: Outbreak of enterovirus D68 of the new B3 lineage in Stockholm, Sweden, August to September 2016
Outbreak of enterovirus D68 of the new B3 lineage in Stockholm, Sweden, August to September 2016 Open
We report an enterovirus D68 (EV-D68) outbreak in Stockholm Sweden in 2016. Between 22 August and 25 September EV-D68 was detected in 74/495 respiratory samples analysed at the Karolinska University Hospital. During the peak week, 30/91 (3…