Robert E. Hampson
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View article: Numerical storm surge modeling and probabilistic analysis for evaluating proposed New Jersey Back Bays inlet closures
Numerical storm surge modeling and probabilistic analysis for evaluating proposed New Jersey Back Bays inlet closures Open
The US Army Corps of Engineers, Philadelphia District, and the New Jersey Department of Environmental Protection are currently engaged in the New Jersey Back Bays (NJBB) Coastal Storm Risk Management Feasibility Study. The US Army Engineer…
View article: Distributed Temporal Coding of Visual Memory Categories in Human Hippocampal Neurons Revealed by an Interpretable Decoding Model
Distributed Temporal Coding of Visual Memory Categories in Human Hippocampal Neurons Revealed by an Interpretable Decoding Model Open
The hippocampus is crucial for forming new episodic memories. While its role in encoding spatial and temporal information (where and when) is well understood, how it encodes objects (what) remains unclear due to the high dimensionality of …
View article: MODELING TIME-VARYING SURGE BARRIERS: THE IMPACT OF CLOSURE TIME AND DURATION ON FLOOD PROTECTION
MODELING TIME-VARYING SURGE BARRIERS: THE IMPACT OF CLOSURE TIME AND DURATION ON FLOOD PROTECTION Open
The research presented in this paper focuses on numerical modeling and analysis of the effects of Storm Surge Barriers (SSBs) or gates, on water levels for a set of 10 hypothetical storm events representative of the range of storm conditio…
View article: Developing a hippocampal neural prosthetic to facilitate human memory encoding and recall of stimulus features and categories
Developing a hippocampal neural prosthetic to facilitate human memory encoding and recall of stimulus features and categories Open
Objective Here, we demonstrate the first successful use of static neural stimulation patterns for specific information content. These static patterns were derived by a model that was applied to a subject’s own hippocampal spatiotemporal ne…
View article: Corrigendum: Patterned hippocampal stimulation facilitates memory in patients with a history of head impact and/or brain injury
Corrigendum: Patterned hippocampal stimulation facilitates memory in patients with a history of head impact and/or brain injury Open
[This corrects the article DOI: 10.3389/fnhum.2022.933401.].
View article: Patterned Hippocampal Stimulation Facilitates Memory in Patients With a History of Head Impact and/or Brain Injury
Patterned Hippocampal Stimulation Facilitates Memory in Patients With a History of Head Impact and/or Brain Injury Open
Rationale: Deep brain stimulation (DBS) of the hippocampus is proposed for enhancement of memory impaired by injury or disease. Many pre-clinical DBS paradigms can be addressed in epilepsy patients undergoing intracranial monitoring for se…
View article: Hippocampal CA1 and CA3 neural recording in the human brain: validation of depth electrode placement through high-resolution imaging and electrophysiology
Hippocampal CA1 and CA3 neural recording in the human brain: validation of depth electrode placement through high-resolution imaging and electrophysiology Open
OBJECTIVE Intracranial human brain recordings typically utilize recording systems that do not distinguish individual neuron action potentials. In such cases, individual neurons are not identified by location within functional circuits. In …
View article: Multi-Input, Multi-Output Neuronal Mode Network Approach to Modeling the Encoding Dynamics and Functional Connectivity of Neural Systems
Multi-Input, Multi-Output Neuronal Mode Network Approach to Modeling the Encoding Dynamics and Functional Connectivity of Neural Systems Open
This letter proposes a novel method, multi-input, multi-output neuronal mode network (MIMO-NMN), for modeling encoding dynamics and functional connectivity in neural ensembles such as the hippocampus. Compared with conventional approaches …
View article: Fibronectin Produced by Cerebral Endothelial and Vascular Smooth Muscle Cells Contributes to Perivascular Extracellular Matrix in Late-Delayed Radiation-Induced Brain Injury
Fibronectin Produced by Cerebral Endothelial and Vascular Smooth Muscle Cells Contributes to Perivascular Extracellular Matrix in Late-Delayed Radiation-Induced Brain Injury Open
Late-delayed radiation-induced brain injury (RIBI) is a major adverse effect of fractionated whole-brain irradiation (fWBI). Characterized by progressive cognitive dysfunction, and associated cerebrovascular and white matter injury, RIBI d…
View article: Developing a hippocampal neural prosthetic to facilitate human memory encoding and recall
Developing a hippocampal neural prosthetic to facilitate human memory encoding and recall Open
These results demonstrate the facilitation of memory encoding which is an important feature for the construction of an implantable neural prosthetic to improve human memory.
View article: Designing Patient-Specific Optimal Neurostimulation Patterns for Seizure Suppression
Designing Patient-Specific Optimal Neurostimulation Patterns for Seizure Suppression Open
Neurostimulation is a promising therapy for abating epileptic seizures. However, it is extremely difficult to identify optimal stimulation patterns experimentally. In this study, human recordings are used to develop a functional 24 neuron …
View article: Evolving Applications, Technological Challenges and Future Opportunities in Neuromodulation: Proceedings of the Fifth Annual Deep Brain Stimulation Think Tank
Evolving Applications, Technological Challenges and Future Opportunities in Neuromodulation: Proceedings of the Fifth Annual Deep Brain Stimulation Think Tank Open
The annual Deep Brain Stimulation (DBS) Think Tank provides a focal opportunity for a multidisciplinary ensemble of experts in the field of neuromodulation to discuss advancements and forthcoming opportunities and challenges in the field. …
View article: Cannabinoids disrupt memory encoding by functionally isolating hippocampal CA1 from CA3
Cannabinoids disrupt memory encoding by functionally isolating hippocampal CA1 from CA3 Open
Much of the research on cannabinoids (CBs) has focused on their effects at the molecular and synaptic level. However, the effects of CBs on the dynamics of neural circuits remains poorly understood. This study aims to disentangle the effec…
View article: Cerebrovascular Remodeling and Neuroinflammation is a Late Effect of Radiation-Induced Brain Injury in Non-Human Primates
Cerebrovascular Remodeling and Neuroinflammation is a Late Effect of Radiation-Induced Brain Injury in Non-Human Primates Open
Fractionated whole-brain irradiation (fWBI) is a mainstay of treatment for patients with intracranial neoplasia; however late-delayed radiation-induced normal tissue injury remains a major adverse consequence of treatment, with deleterious…
View article: Sparse Large-Scale Nonlinear Dynamical Modeling of Human Hippocampus for Memory Prostheses
Sparse Large-Scale Nonlinear Dynamical Modeling of Human Hippocampus for Memory Prostheses Open
In order to build hippocampal prostheses for restoring memory functions, we build sparse multi-input, multi-output (MIMO) nonlinear dynamical models of the human hippocampus. Spike trains are recorded from hippocampal CA3 and CA1 regions o…
View article: Distributed encoding of spatial and object categories in primate hippocampal microcircuits
Distributed encoding of spatial and object categories in primate hippocampal microcircuits Open
The primate hippocampus plays critical roles in the encoding, representation, categorization and retrieval of cognitive information. Such cognitive abilities may use the transformational input-output properties of hippocampal laminar micro…
View article: Distinguishing cognitive state with multifractal complexity of hippocampal interspike interval sequences
Distinguishing cognitive state with multifractal complexity of hippocampal interspike interval sequences Open
Fractality, represented as self-similar repeating patterns, is ubiquitous in nature and the brain. Dynamic patterns of hippocampal spike trains are known to exhibit multifractal properties during working memory processing; however, it is u…
View article: Hippocampal closed-loop modeling and implications for seizure stimulation design
Hippocampal closed-loop modeling and implications for seizure stimulation design Open
Deep-brain stimulation (DBS) is a new and promising therapy for intractable seizures. Currently, there is no efficient way to determine optimal frequency parameters for DBS, or even whether periodic or broadband stimuli are optimal. Data-b…
View article: Disruption of columnar and laminar cognitive processing in primate prefrontal cortex following cocaine exposure
Disruption of columnar and laminar cognitive processing in primate prefrontal cortex following cocaine exposure Open
Prefrontal cortical activity in primate brain plays a critical role in cognitive processes involving working memory and the executive control of behavior. Groups of prefrontal cortical neurons within specified cortical layers along cortica…