Robert E. Hurst
YOU?
Author Swipe
View article: Development of a unique crosslinked glycosaminoglycan for soft tissue repair: Treatment of interstitial cystitis/bladder pain syndrome
Development of a unique crosslinked glycosaminoglycan for soft tissue repair: Treatment of interstitial cystitis/bladder pain syndrome Open
Chemical modification of naturally derived glycosaminoglycans (GAGs) expands their potential utility for applications in soft tissue repair and regenerative medicine. Here we report the preparation of a novel crosslinked chondroitin sulfat…
View article: The urothelial barrier in interstitial cystitis/bladder pain syndrome: its form and function, an overview of preclinical models
The urothelial barrier in interstitial cystitis/bladder pain syndrome: its form and function, an overview of preclinical models Open
Purpose of review Investigating bladder pain syndrome/interstitial cystitis (IC/BPS) preclinically is challenging. Various research models have been used to mimic the urothelial barrier closely and replicate the disease. The aim of this re…
View article: MRI as a Tool to Assess Interstitial Cystitis Associated Bladder and Brain Pathologies
MRI as a Tool to Assess Interstitial Cystitis Associated Bladder and Brain Pathologies Open
Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic, often incapacitating condition characterized by pain seeming to originate in the bladder in conjunction with lower urinary tract symptoms of frequency and urgency, and cons…
View article: Innovative Approaches in the Battle Against Cancer Recurrence: Novel Strategies to Combat Dormant Disseminated Tumor Cells
Innovative Approaches in the Battle Against Cancer Recurrence: Novel Strategies to Combat Dormant Disseminated Tumor Cells Open
Cancer recurrence remains a great fear for many cancer survivors following their initial, apparently successful, therapy. Despite significant improvement in the overall survival of many types of cancer, metastasis accounts for ~90% of all …
View article: SuperGAG biopolymers for treatment of excessive bladder permeability
SuperGAG biopolymers for treatment of excessive bladder permeability Open
Few therapeutic options exist for treatment of IC/BPS. A novel high MW GAG biopolymer (“SuperGAG”) was synthesized by controlled oligomerization of CS, purified by TFF and characterized by SEC‐MALLS and 1H‐NMR spectroscopy. The modified GA…
View article: In vivo and ex vivo assessment of bladder hyper-permeability and using molecular targeted magnetic resonance imaging to detect claudin-2 in a mouse model for interstitial cystitis
In vivo and ex vivo assessment of bladder hyper-permeability and using molecular targeted magnetic resonance imaging to detect claudin-2 in a mouse model for interstitial cystitis Open
The combination of CE-MRI and TEER approaches were able to demonstrate hyper-permeability, a known feature associated with some IC/BPS patients, in the LPS-exposed URO-MCP-1 mouse model. This MRI approach could be clinically translated to …
View article: Assessing bladder hyper-permeability biomarkers <i>in vivo</i> using molecularly-targeted MRI.
Assessing bladder hyper-permeability biomarkers <i>in vivo</i> using molecularly-targeted MRI. Open
The objective was to investigate if some of the key molecular players associated with bladder hyper-permeability in interstitial cystitis/bladder pain syndrome (IC/BPS) could be visualized with molecularly-targeted magnetic resonance imagi…
View article: Issue Information
Issue Information Open
Part B: Applied Biomaterials is a highly interdisciplinary peer-reviewed journal serving the needs of biomaterials professionals who design, develop, produce and apply biomaterials and medical devices.It has the common focus of biomaterial…
View article: MP28-12 MECHANISMS OF STRESS-INDUCED BLADDER DYSFUNCTION: A NOVEL ROLE FOR ALTERATIONS IN URINARY BLADDER PERMEABILITY
MP28-12 MECHANISMS OF STRESS-INDUCED BLADDER DYSFUNCTION: A NOVEL ROLE FOR ALTERATIONS IN URINARY BLADDER PERMEABILITY Open
You have accessJournal of UrologyBladder & Urethra: Anatomy, Physiology & Pharmacology I1 Apr 2016MP28-12 MECHANISMS OF STRESS-INDUCED BLADDER DYSFUNCTION: A NOVEL ROLE FOR ALTERATIONS IN URINARY BLADDER PERMEABILITY EHSAN MOHAMMADI, NIRAN…
View article: MP61-09 EARLY DEVELOPMENT OF INTRAVESICAL REFLECTANCE SPECTROSCOPY FOR BLADDER TUMOR DETECTION AND STAGING
MP61-09 EARLY DEVELOPMENT OF INTRAVESICAL REFLECTANCE SPECTROSCOPY FOR BLADDER TUMOR DETECTION AND STAGING Open
You have accessJournal of UrologyBladder Cancer: Basic Research & Pathophysiology II1 Apr 2016MP61-09 EARLY DEVELOPMENT OF INTRAVESICAL REFLECTANCE SPECTROSCOPY FOR BLADDER TUMOR DETECTION AND STAGING Joel Slaton, Robert Hurst, Carole Davi…
View article: MP68-16 FUNCTIONAL SIGNFICANCE OF INCREASED BLADDER PERMEABILITY: A NOVEL ROLE IN VISCERAL ORGAN CROSSTALK.
MP68-16 FUNCTIONAL SIGNFICANCE OF INCREASED BLADDER PERMEABILITY: A NOVEL ROLE IN VISCERAL ORGAN CROSSTALK. Open
You have accessJournal of UrologyUrodynamics/Lower Urinary Tract Dysfunction/Female Pelvic Medicine: Basic Research & Pathophysiology II1 Apr 2016MP68-16 FUNCTIONAL SIGNFICANCE OF INCREASED BLADDER PERMEABILITY: A NOVEL ROLE IN VISCERAL OR…
View article: In the absence of overt urothelial damage, chondroitinase ABC digestion of the GAG layer increases bladder permeability in ovariectomized female rats
In the absence of overt urothelial damage, chondroitinase ABC digestion of the GAG layer increases bladder permeability in ovariectomized female rats Open
Loss of integrity of the protective impermeability barrier in the urothelium has been identified as significant in bladder dysfunction. In this study, we tested the theory that the luminal layer of glycosaminoglycans (GAG) serves as an imp…
View article: Targeting dormant micrometastases: rationale, evidence to date and clinical implications
Targeting dormant micrometastases: rationale, evidence to date and clinical implications Open
In spite of decades of research, cancer survival has increased only modestly. This is because most research is based on models of primary tumors. Slow recognition has begun that disseminated, dormant cancer cells (micrometastatic cells) th…