Robert E. Sorge
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View article: Myeloid-specific Tristetraprolin mitigates postsurgical incisional pain by suppressing proinflammatory responses
Myeloid-specific Tristetraprolin mitigates postsurgical incisional pain by suppressing proinflammatory responses Open
Background: Proinflammatory mediators including COX-2, IL-1β, IL-6, and TNF-α, play major roles in the initiation of postsurgical pain. Produced primarily by activated macrophages and microglia, these mediators drive hyperexcitation of noc…
View article: Myeloid-specific Tristetraprolin mitigates postsurgical incisional pain by suppressing proinflammatory responses
Myeloid-specific Tristetraprolin mitigates postsurgical incisional pain by suppressing proinflammatory responses Open
Background Proinflammatory mediators including COX-2, IL-1β, IL-6, and TNF-α, play major roles in the initiation of postsurgical pain. Produced primarily by activated macrophages and microglia, these mediators drive hyperexcitation of noci…
View article: Association of National Area Deprivation Index with dietary patterns and pain-related inflammatory biomarkers in community-dwelling adults with chronic low back pain
Association of National Area Deprivation Index with dietary patterns and pain-related inflammatory biomarkers in community-dwelling adults with chronic low back pain Open
Introduction Chronic low back pain (cLBP) is a common health condition associated with substantial personal and economic costs. Recent literature suggests that socioeconomic status (SES) and diet quality may influence its impact. Methods T…
View article: A Pilot Study: Comparative Effects of Green Tea Extract and Duloxetine on Oxaliplatin-Induced Allodynia in a Murine Model
A Pilot Study: Comparative Effects of Green Tea Extract and Duloxetine on Oxaliplatin-Induced Allodynia in a Murine Model Open
Background/Objectives: The purpose of this preclinical pilot study was to explore the potential of green tea extract (GTE) to mitigate and/or prevent oxaliplatin-induced allodynia and axonal damage in rats, when compared to duloxetine (DLX…
View article: High-risk alcohol consumption is associated with mitochondrial damage-associated molecular patterns in people living with HIV
High-risk alcohol consumption is associated with mitochondrial damage-associated molecular patterns in people living with HIV Open
View article: Inhibition of the <scp>RNA</scp> Regulator <scp>HuR</scp> Mitigates Spinal Cord Injury by Potently Suppressing Post‐Injury Neuroinflammation
Inhibition of the <span>RNA</span> Regulator <span>HuR</span> Mitigates Spinal Cord Injury by Potently Suppressing Post‐Injury Neuroinflammation Open
Neuroinflammation is a major driver of secondary tissue damage after spinal cord injury (SCI). Within minutes after SCI, activated microglia and astrocytes produce proinflammatory mediators such as TNF‐α, IL‐6, iNOS, and COX‐2 which induce…
View article: Investigation of the Impact of a Low-Carbohydrate Diet on The Chronic Pain Experience Among Adults with an Acquired Limb Loss: A Pilot Study
Investigation of the Impact of a Low-Carbohydrate Diet on The Chronic Pain Experience Among Adults with an Acquired Limb Loss: A Pilot Study Open
These results suggest that an LCD might have an influence on multiple chronic pain-related factors among adults living with an amputation. Furthermore, adults living with chronic PLP/RLP may report high resilience, although high levels of …
View article: The effect of a low-carbohydrate diet on evoked pain and quality of life in Non-Hispanic black women with knee osteoarthritis: a pilot study
The effect of a low-carbohydrate diet on evoked pain and quality of life in Non-Hispanic black women with knee osteoarthritis: a pilot study Open
View article: Inhibition of the RNA Regulator HuR mitigates spinal cord injury by potently suppressing post-injury neuroinflammation
Inhibition of the RNA Regulator HuR mitigates spinal cord injury by potently suppressing post-injury neuroinflammation Open
Background Neuroinflammation plays a significant role in promoting secondary tissue injury after spinal cord trauma. Within minutes after spinal cord injury (SCI), microglia and astrocytes become activated and produce inflammatory mediator…
View article: The pace of biological aging significantly mediates the relationship between internalized stigma of chronic pain and chronic low back pain severity among non-hispanic black but not non-hispanic white adults
The pace of biological aging significantly mediates the relationship between internalized stigma of chronic pain and chronic low back pain severity among non-hispanic black but not non-hispanic white adults Open
This study aimed to determine the nature of the relationship between the internalized stigma of chronic pain (ISCP), the pace of biological aging, and racial disparities in nonspecific chronic low back pain (CLBP). We used Dunedin Pace of …
View article: Mitochondrial reactivity following acute exposure to experimental pain testing in people with HIV and chronic pain
Mitochondrial reactivity following acute exposure to experimental pain testing in people with HIV and chronic pain Open
Background: Physical stressors can cause a physiological response that can contribute to an increase in mitochondrial dysfunction and Mitochondrial DNA damage (mtDNA damage). People living with HIV (PWH) are more likely to suffer from chro…
View article: The pace of biological aging helps explain the association between insomnia and chronic low back pain
The pace of biological aging helps explain the association between insomnia and chronic low back pain Open
Chronic low back pain (cLBP) is associated with insomnia and advanced age. Emerging evidence suggests that the severity of both sleep disorders (like insomnia) and chronic pain are associated with a faster pace of biological aging. We aime…
View article: Attenuation Of Chronic Pain In Male And Female Mice Through Inhibition Of The RNA Regulator, HuR
Attenuation Of Chronic Pain In Male And Female Mice Through Inhibition Of The RNA Regulator, HuR Open
View article: Racial Differences in 25-Hydroxy Vitamin D and Self-Reported Pain Severity in a Sample of Individuals Living with Non-Specific Chronic Low Back Pain
Racial Differences in 25-Hydroxy Vitamin D and Self-Reported Pain Severity in a Sample of Individuals Living with Non-Specific Chronic Low Back Pain Open
The findings suggest that Vitamin D deficiency may be linked to greater pain severity in a sample of individuals with cLBP, especially for those who identify as NHB.
View article: The neurobiology of social stress resulting from Racism: Implications for pain disparities among racialized minorities
The neurobiology of social stress resulting from Racism: Implications for pain disparities among racialized minorities Open
Extant literature posits that humans experience two types of threat: physical threat and social threat. While describing pain as "physical" or "social" can be helpful for understanding pain origins (i.e., broken bone versus lost relationsh…
View article: Inhibition of the RNA Regulator HuR by SRI-42127 Attenuates Neuropathic Pain After Nerve Injury Through Suppression of Neuroinflammatory Responses
Inhibition of the RNA Regulator HuR by SRI-42127 Attenuates Neuropathic Pain After Nerve Injury Through Suppression of Neuroinflammatory Responses Open
View article: Biomarkers of Inflammation in Non-Specific Chronic Low Back Pain: Differences According to Chronic Pain Status and Racial
Biomarkers of Inflammation in Non-Specific Chronic Low Back Pain: Differences According to Chronic Pain Status and Racial Open
View article: Dietary Inflammatory Index (DII) is Associated with Movement-Evoked Pain Severity in Adults with Chronic Low Back Pain: Sociodemographic Differences.
Dietary Inflammatory Index (DII) is Associated with Movement-Evoked Pain Severity in Adults with Chronic Low Back Pain: Sociodemographic Differences. Open
View article: An improved model of type 2 diabetes with effects on glucose tolerance, neuropathy and retinopathy with and without obesity
An improved model of type 2 diabetes with effects on glucose tolerance, neuropathy and retinopathy with and without obesity Open
View article: Racial Differences in Pain, Nutrition, and Oxidative Stress
Racial Differences in Pain, Nutrition, and Oxidative Stress Open
View article: Relationship Between Diet and Relative Risk of Pain in a Cross-Sectional Analysis of the REGARDS Longitudinal Study
Relationship Between Diet and Relative Risk of Pain in a Cross-Sectional Analysis of the REGARDS Longitudinal Study Open
Aim: Determine if dietary patterns affect risk of pain. Methods: Data from 16,061 participants (55.4% females, 32.3% Black, age 65 ± 9 years) in the REGARDS study were categorized based on the adherence to previous dietary pa…
View article: Sleep and neighborhood socioeconomic status: a micro longitudinal study of chronic low-back pain and pain-free individuals
Sleep and neighborhood socioeconomic status: a micro longitudinal study of chronic low-back pain and pain-free individuals Open
View article: Temporal summation of mechanical pain prospectively predicts movement-evoked pain severity in adults with chronic low back pain
Temporal summation of mechanical pain prospectively predicts movement-evoked pain severity in adults with chronic low back pain Open
Background Biopsychosocial factors above and beyond pathoanatomical changes likely contribute to the severity of chronic low back pain. A pro-nociceptive endogenous pain modulatory balance (↓inhibition and ↑facilitation) may be an importan…
View article: Obesity diminishes response to PD-1-based immunotherapies in renal cancer
Obesity diminishes response to PD-1-based immunotherapies in renal cancer Open
Background Obesity is a major risk factor for renal cancer, yet our understanding of its effects on antitumor immunity and immunotherapy outcomes remains incomplete. Deciphering these associations is critical, given the growing clinical us…
View article: Dietary Interventions for Treatment of Chronic Pain: Oxidative Stress and Inflammation
Dietary Interventions for Treatment of Chronic Pain: Oxidative Stress and Inflammation Open
Chronic pain is highly prevalent in the United States, impacting 28.4% of the adult population, or 69.6 million people, as of 2016. Chronic pain is often associated with anxiety, depression, and restrictions in mobility and daily activitie…
View article: Obesity-Associated Myeloid-Derived Suppressor Cells Promote Apoptosis of Tumor-Infiltrating CD8 T Cells and Immunotherapy Resistance in Breast Cancer
Obesity-Associated Myeloid-Derived Suppressor Cells Promote Apoptosis of Tumor-Infiltrating CD8 T Cells and Immunotherapy Resistance in Breast Cancer Open
Nearly 70% of adults in the US are currently overweight or obese. Despite such high prevalence, the impact of obesity on antitumor immunity and immunotherapy outcomes remains incompletely understood, particularly in patients with breast ca…
View article: The sad weekend: A perilous North American tradition
The sad weekend: A perilous North American tradition Open
Obesity is a global concern and affects millions of Americans who consume poor-quality diets. Diets directly affect the gut microbiota, which can have subsequent effects on inflammation and contribute to other chronic states. Previously we…
View article: Spinal Mobilization Prevents NGF-Induced Trunk Mechanical Hyperalgesia and Attenuates Expression of CGRP
Spinal Mobilization Prevents NGF-Induced Trunk Mechanical Hyperalgesia and Attenuates Expression of CGRP Open
SM prevents the development of local (trunk) NGF-induced mechanical hyperalgesia and distant (hindpaw) allodynia, in part, through attenuation of CGRP expression in lumbar DRG sensory neurons. NGF decreases rat exploratory behavior and inc…
View article: <p>Sex and Gender are Not the Same: Why Identity Is Important for People Living with HIV and Chronic Pain</p>
Sex and Gender are Not the Same: Why Identity Is Important for People Living with HIV and Chronic Pain Open
These data support the notion that gender identity may play a more significant role in pain sensation than genetic sex. These results further maintain that not only gender identity and genetic sex are distinct variables but that treatment …
View article: The Effect of Low-Carbohydrate and Low-Fat Diets on Pain in Individuals with Knee Osteoarthritis
The Effect of Low-Carbohydrate and Low-Fat Diets on Pain in Individuals with Knee Osteoarthritis Open
Objective Osteoarthritis is the most prominent form of arthritis, affecting approximately 15% of the population in the United States. Knee osteoarthritis (KOA) has become one of the leading causes of disability in older adults. Besides kne…