Explanipedia

ARL13B-Cerulean rescues Arl13b-null mouse from embryonic lethality and reveals a role for ARL13B in spermatogenesis Open

Alyssa B. Long, Isabella M. Wilson, Tiffany T. Terry, Robert E. Van Sciver, Tamara Caspary · 2025

Biology

ARL13B is a regulatory GTPase enriched in cilia, making it a popular marker for this organelle. Arl13b hnn/hnn mice lack ARL13B expression, die during midgestation, and exhibit defects in ciliogenesis. The R26Arl13b-Fucci2aR biosensor mous…

A prioritization tool for cilia-associated genes and their in vivo resources unveils new avenues for ciliopathy research Open

Robert E. Van Sciver, Tamara Caspary · 2024

Biology Business

Defects in ciliary signaling or mutations in proteins that localize to primary cilia lead to a class of human diseases known as ciliopathies. Approximately 10% of mammalian genes encode cilia-associated proteins, and a major gap in the cil…

Ciliary ARL13B inhibits developmental kidney cystogenesis in mouse Open

Robert E. Van Sciver, Alyssa B. Long, Harrison Katz, Eduardo D. Gigante, Tamara Caspary · 2023

Biology Medicine

ARL13B is a small GTPase enriched in cilia. Deletion of Arl13b in mouse kidney results in renal cysts and an associated absence of primary cilia. Similarly, ablation of cilia leads to kidney cysts. To investigate whether ARL13B functions f…

Let’s talk about race: changing the conversations around race in academia Open

Jasmine M. Miller‐Kleinhenz, Alexandra B. Kuzmishin Nagy, Ania A. Majewska, Adeola O. Adebayo Michael, Saman M. Najmi , et al. · 2021

Sociology Political science

Jasmine Miller-Kleinhenz et al. highlight the risk of science and academia’s general neutrality to discussions around race and social justice. Their collectively-developed course represents a framework to begin these important discussions …

Unmet Clinical Need: Developing Prognostic Biomarkers and Precision Medicine to Forecast Early Tumor Relapse, Detect Chemo-Resistance and Improve Overall Survival in High-Risk Breast Cancer Open

Gupta Gagan, Lee Caroline Dasom, Guye Mary L, Robert E. Van Sciver, Lee P , et al. · 2020

Medicine Biology

Chemo-resistant breast cancer is a major barrier to curative treatment for a significant number of women with breast cancer. Neoadjuvant chemotherapy (NACT) is standard first- line treatment for most women diagnosed with high-risk TNBC, HE…

The phylogenetic functional conservation ofDrosophilaSeven-In-Absentia (SINA) E3 ligase and its two human paralogs, SIAH1 and SIAH2, inDrosophilaeye development Open

Robert E. Van Sciver, Yajun Cao, Amy Tang · 2020

Biology

Seven-IN-Absentia (SINA) is the most downstream signaling gatekeeper identified thus far in the RAS/EGFR pathway that controls photoreceptor cell fate determination in Drosophila . Underscoring the central importance of SINA is its phyloge…

Abstract 83: The critical role of seven-in-absentia (SINA) family E3 ligases in normal development and oncogenic K-RAS-driven human cancer Open

Robert E. Van Sciver, Yajun Cao, Atique U. Ahmed, Amy Tang · 2019

Biology

There will be an estimated 1.8 million new cancer diagnoses in the US this year alone, with >80% of these cases driven by oncogenic K-RAS/SIAH pathway activation, even in the absence of oncogenic RAS mutations. Over three decades of intens…

A New Strategy to Control and Eradicate “Undruggable” Oncogenic K-RAS-Driven Pancreatic Cancer: Molecular Insights and Core Principles Learned from Developmental and Evolutionary Biology Open

Robert E. Van Sciver, Michael Lee, Caroline Lee, Alex Lafever, Elizaveta Svyatova , et al. · 2018

Biology

Oncogenic K-RAS mutations are found in virtually all pancreatic cancers, making K-RAS one of the most targeted oncoproteins for drug development in cancer therapies. Despite intense research efforts over the past three decades, oncogenic K…

Phylogenetic analysis of the SINA/SIAH ubiquitin E3 ligase family in Metazoa Open