Robert Eferl
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View article: TYK2 Promotes Immunosurveillance of Colorectal Cancer Liver Metastasis
TYK2 Promotes Immunosurveillance of Colorectal Cancer Liver Metastasis Open
Colorectal cancer liver metastasis (CRLM) is a major clinical problem. The regulators of immunosurveillance of CRLM could hold potential for developing therapeutic strategies to prevent or treat metastasis. In this study, using a murine co…
View article: Polystyrene micro- and nanoplastics in a colitis mouse model – effects on biodistribution, macrophage polarization, and gut microbiome
Polystyrene micro- and nanoplastics in a colitis mouse model – effects on biodistribution, macrophage polarization, and gut microbiome Open
The increasing prevalence of inflammatory bowel disease (IBD) and rising pollution from micro-and nanoplastic (MNP) particles has prompted investigations on their potential interconnection. To elucidate the complex relationship between IBD…
View article: Loss of SPHK1 fuels inflammation to drive KRAS-mutated lung adenocarcinoma
Loss of SPHK1 fuels inflammation to drive KRAS-mutated lung adenocarcinoma Open
Inflammation is a widely recognized key contributor to KRAS-driven lung adenocarcinoma (LUAD). Tumor-associated macrophages (TAM) are an integral part of the tumor microenvironment and create a supportive niche that sustains inflammation-d…
View article: Radiation‐Enhanced <scp>AF1q</scp> Moves Center Stage as a Key Driver to Favorable Tumor Stage in Rectal Cancer Patients
Radiation‐Enhanced <span>AF1q</span> Moves Center Stage as a Key Driver to Favorable Tumor Stage in Rectal Cancer Patients Open
Background Enhanced protein expression of ALL1‐fused gene from chromosome 1q ( AF1Q ) after (chemo)radiotherapy has been described in vitro, but is largely understudied in gastrointestinal cancer. We aimed to investigate AF1q expression in…
View article: Cell-autonomous IL6ST activation suppresses prostate cancer development via STAT3/ARF/p53-driven senescence and confers an immune-active tumor microenvironment
Cell-autonomous IL6ST activation suppresses prostate cancer development via STAT3/ARF/p53-driven senescence and confers an immune-active tumor microenvironment Open
Our findings demonstrate a context-dependent role of IL6ST/STAT3 in carcinogenesis and a tumor-suppressive function in prostate cancer development by inducing senescence and immune cell attraction. We challenge the prevailing concept of bl…
View article: Polystyrene micro- and nanoplastics aggravates colitis in a mouse model – effects on biodistribution, macrophage polarization, and gut microbiome
Polystyrene micro- and nanoplastics aggravates colitis in a mouse model – effects on biodistribution, macrophage polarization, and gut microbiome Open
Background The increasing prevalence of inflammatory bowel disease (IBD) and rising pollution from micro- and nanoplastic (MNP) particles has prompted investigations on their potential interconnection. To elucidate the complex relationship…
View article: Type I and II interferon signaling in colorectal cancer liver metastasis
Type I and II interferon signaling in colorectal cancer liver metastasis Open
Metastatic colorectal cancer is one of the leading causes of cancer-related deaths worldwide. Traditional chemotherapy extended the lifespan of cancer patients by only a few months, but targeted therapies and immunotherapy prolonged surviv…
View article: The intermicrovillar adhesion complex in gut barrier function and inflammation
The intermicrovillar adhesion complex in gut barrier function and inflammation Open
The surface of intestinal epithelial cells is covered by the brush border, which consists of densely packed cellular extrusions called microvilli. Until recently, microvilli have not been known to be interconnected. In 2014, a protein comp…
View article: Tyk2 is a tumor suppressor in colorectal cancer
Tyk2 is a tumor suppressor in colorectal cancer Open
Janus kinase Tyk2 is implicated in cancer immune surveillance, but its role in solid tumors is not well defined. We used Tyk2 knockout mice (Tyk2Δ/Δ) and mice with conditional deletion of Tyk2 in hematopoietic (Tyk2ΔHem) or intestinal epit…
View article: AOM/DSS Induced Colitis-Associated Colorectal Cancer in 14-Month-Old Female Balb/C and C57/Bl6 Mice—A Pilot Study
AOM/DSS Induced Colitis-Associated Colorectal Cancer in 14-Month-Old Female Balb/C and C57/Bl6 Mice—A Pilot Study Open
Colitis is a major risk factor for the development of colorectal cancer, leading to colitis-associated colorectal cancer (CAC). The most commonly used animal model to study CAC is the azoxymethane-dextran sulphate-sodium (AOM/DSS) model. T…
View article: Morphometric Analysis of Mast Cells in Tumor Predicts Recurrence of Hepatocellular Carcinoma After Liver Transplantation
Morphometric Analysis of Mast Cells in Tumor Predicts Recurrence of Hepatocellular Carcinoma After Liver Transplantation Open
Tumor‐infiltrating immune cells are relevant prognostic and immunotherapeutic targets in hepatocellular carcinoma (HCC). Mast cells play a key role in allergic response but may also be involved in anticancer immunity. Digital morphometric …
View article: Down-regulation of A20 promotes immune escape of lung adenocarcinomas
Down-regulation of A20 promotes immune escape of lung adenocarcinomas Open
A20 represents an immune checkpoint in lung adenocarcinomas, and its loss may be compensated by targeting the TBK1–STAT1–PD-L1 axis.
View article: A Mouse Model to Assess STAT3 and STAT5A/B Combined Inhibition in Health and Disease Conditions
A Mouse Model to Assess STAT3 and STAT5A/B Combined Inhibition in Health and Disease Conditions Open
Genetically-engineered mouse models (GEMMs) lacking diseased-associated gene(s) globally or in a tissue-specific manner represent an attractive tool with which to assess the efficacy and toxicity of targeted pharmacological inhibitors. Sta…
View article: JAK–STAT inhibition impairs K‐RAS‐driven lung adenocarcinoma progression
JAK–STAT inhibition impairs K‐RAS‐driven lung adenocarcinoma progression Open
Oncogenic K‐RAS has been difficult to target and currently there is no K‐RAS‐based targeted therapy available for patients suffering from K‐RAS‐driven lung adenocarcinoma (AC). Alternatively, targeting K‐RAS‐downstream effectors, K‐RAS‐coo…
View article: IL-1 receptor blockade skews inflammation towards Th2 in a mouse model of systemic sclerosis
IL-1 receptor blockade skews inflammation towards Th2 in a mouse model of systemic sclerosis Open
The interleukin (IL)-1 family of cytokines is strongly associated with systemic sclerosis (SSc) and pulmonary involvement, but the molecular mechanisms are poorly understood. The aim of this study was to assess the role of IL-1α and IL-1β …
View article: Afatinib restrains K-RAS–driven lung tumorigenesis
Afatinib restrains K-RAS–driven lung tumorigenesis Open
K-RAS –mutated lung adenocarcinomas depend on ERBB signaling, and pan-ERBB inhibitors impair K-RAS–driven lung tumorigenesis.
View article: STAT1 is a sex‐specific tumor suppressor in colitis‐associated colorectal cancer
STAT1 is a sex‐specific tumor suppressor in colitis‐associated colorectal cancer Open
The interferon‐inducible transcription factor STAT1 is a tumor suppressor in various malignancies. We investigated sex‐specific STAT1 functions in colitis and colitis‐associated colorectal cancer (CRC) using mice with specific STAT1 deleti…
View article: Impact of glutathione peroxidase 4 on cell proliferation, angiogenesis and cytokine production in hepatocellular carcinoma
Impact of glutathione peroxidase 4 on cell proliferation, angiogenesis and cytokine production in hepatocellular carcinoma Open
Insufficient supplementation with the micronutrient selenium and persistent hepatic inflammation predispose to hepatocellular carcinoma (HCC). Inflammation-associated reactive oxygen species attack membrane lipids and form lipid hydroperox…
View article: <scp>AKT</scp>3 drives adenoid cystic carcinoma development in salivary glands
<span>AKT</span>3 drives adenoid cystic carcinoma development in salivary glands Open
Salivary gland cancer is an aggressive and painful cancer, but a rare tumor type accounting for only ~0.5% of cancer cases. Tumors of the salivary gland exhibit heterogeneous histologic and genetic features and they are subdivided into dif…