Explanipedia

Skeletal muscle oxygenation and fluid content in upper extremity postthrombotic syndrome: a proof-of-concept study Open

Laura Avila, Scott Thomas, Athena Mancini, Gina Wong, Brenda Wong , et al. · 2025

The lower SmO₂ suggests that UE-PTS severity is associated with muscle microvascular dysfunction and impaired blood flow during and following exercise.

Pre- and postcapillary exercise contributions to pulmonary hypertension in adults > 45 yr Open

E. Karvasarski, Joy-Sumin Park, Simone Louise Savaris, A. Beale, Stephen P. Wright , et al. · 2025

Exercise is recommended in patients with pulmonary artery wedge pressure (PAWP) between 12 and 15 mmHg and risk factors for left-heart disease to differentiate pre- versus postcapillary contributions to pulmonary hypertension (PH). However…

The contribution of red blood cell desaturation to exercising skeletal muscle vasodilation heterogeneity Open

Jacob L. Schwartz, Adam N. Di Salvo, Jonaline B. Bernal, Sinan Osman, Robert F. Bentley · 2025

When challenging muscle blood flow during small muscle mass exercise, compensatory vasodilation may protect the matching of oxygen delivery to the muscle’s oxygen demand. The present study extended previous work by revealing an absence of …

The effect of body position on cardiovascular, skeletal muscle and ventilatory responses to submaximal cycling Open

Robert F. Bentley, Jonaline B. Bernal, Daniel C. Basile, Adam N. Di Salvo, Jacob L. Schwartz · 2024

The completion of exercise in different body positions can impact the function of various components of the oxygen delivery pathway; however, the effect of the haemodynamic conditions induced by a semi‐upright body position on the integrat…

Impact of Positive Airway Pressure on Right Ventricular Afterload in Pulmonary Arterial Hypertension Open

Robert F. Bentley, Shaun Yo, K. Hun Mok, Felipe Homem Valle, Ewan C. Goligher , et al. · 2024

Rationale The impact of continuous positive airway pressure (CPAP) is currently unknown in patients with pulmonary arterial hypertension (PAH). Objective To investigate the effect of CPAP on cardiopulmonary hemodynamics in patients with (P…

The effect of self-identified arm dominance on exercising forearm hemodynamics and skeletal muscle desaturation Open

Jacob L. Schwartz, Trishawna A. Fongwoo, Robert F. Bentley · 2024

The human forearm model is commonly employed in physiological investigations exploring local vascular function and oxygen delivery; however, the effect of arm dominance on exercising forearm hemodynamics and skeletal muscle oxygen saturati…

Exercise‐Dependent Modulation of Immunological Response Pathways in Endurance Athletes With and Without Atrial Fibrillation Open

David Dorian, Dakota Gustafson, Ryan Quinn, Robert F. Bentley, Paul Dorian , et al. · 2024

Background Atrial fibrillation (AF) is a common arrhythmia characterized by uncoordinated atrial electrical activity. Lone AF occurs in the absence of traditional risk factors and is frequently observed in male endurance athletes, who face…

Atrial fibrillation in middle-aged athletes: Impact on left atrial, ventricular and exercise performance Open

Emily Vecchiarelli, Robert F. Bentley, Kim A. Connelly, Paul Dorian, Andrew T. Yan , et al. · 2024

High volume endurance training may increase the risk of paroxysmal atrial fibrillation (AF) in middle-aged athletes. Limited data are available describing the cardiovascular phenotype of middle-aged endurance athletes, or the impact of AF …

Exercise and pulsatile pulmonary vascular loading in chronic thromboembolic pulmonary disease Open

Sinan Osman, Natasha R. Girdharry, E. Karvasarski, Robert F. Bentley, Stephen P. Wright , et al. · 2024

Chronic thromboembolic pulmonary disease (CTEPD) is characterized by organized nonresolving thrombi in pulmonary arteries (PA). In CTEPD with pulmonary hypertension (PH), chronic thromboembolic PH (CTEPH), early wave reflection results in …

Long-term outcomes of pulmonary embolism in children and adolescents Open

Denise Bastas, Leonardo R. Brandão, Jennifer Vincelli, David C. Wilson, Lucy Perrem , et al. · 2023

Knowledge regarding the long-term consequences of pulmonary embolism (PE) in children is limited. This cohort study describes the long-term outcomes of PE in children who were followed-up at a single-center institution using a local protoc…

Objective and Subjective Assessments of Exercise Burden in Masters Athletes Are Poorly Correlated Open

Jennifer Lewis, Robert F. Bentley, Kim A. Connelly, Paul Dorian, Jack M. Goodman · 2023

Accurate quantification of exercise volume (burden) is crucial for understanding links between exercise and cardiovascular outcomes in older endurance athletes (EA). Exercise burden, an integral of intensity and duration (MET·min), is typi…

Atrial Fibrillation in Middle-Aged Athletes: Impact on Left Atrial, Ventricular and Exercise Performance Open

Emily Vecchiarelli, Robert F. Bentley, K.A. Connelly, Paul Dorian, Andrew T. Yan , et al. · 2023

High volume endurance training may increase the risk of paroxsysmal atrial fibrillation (AF) in middle-aged athletes. Limited data are available describing the cardiovascular phenotype of middle-aged endurance athletes, or the impact of AF…

OC 48.5 Respiratory, Cardiac, and Exertional Function Post-Pulmonary Embolism in Children Open

Denise Bastas, Leonardo R. Brandão, David C. Wilson, Lucy Perrem, Robert F. Bentley , et al. · 2023

Aims: The principal objective of this investigation was to identify the VTE rate and risk profile in TGD youth followed at our quaternary-care center.Methods: Permission from the Institutional Review Board was obtained.Hospital systems wer…

The Relationship Between Resting and Exercise Haemodynamics and Anatomical Distribution of Chronic Thromboembolic Pulmonary Disease Open

A. Beale, Micheal McInnis, Sinan Osman, Simone Louise Savaris, Nafiseh Valaei Sharif , et al. · 2023

Unraveling the pathophysiology of lower-limb postthrombotic syndrome in adolescents: a proof-of-concept study Open

Laura Avila, Robert F. Bentley, Denise Bastas, Leonardo R. Brandão, Jane E. Schneiderman , et al. · 2023

A better understanding of the pathophysiology of pediatric postthrombotic syndrome (PTS) is needed to develop strategies to treat this condition. We investigated calf pump function, exercise capacity, balance in power output, and changes i…

Psychosocial interprofessional perinatal education: Design and evaluation of an interprofessional learning experience to improve students’ collaboration skills in perinatal mental health Open

Hazel Keedle, Virginia Stulz, Janet Conti, Robert F. Bentley, Tanya Meade , et al. · 2023

Through this innovative, simulated interprofessional education workshop students developed skills essential for future collaborative practice to support women and families experiencing psychosocial distress.

Alterations of pulmonary vascular afterload in exercise‐induced pre‐ and post‐capillary pulmonary hypertension Open

E. Karvasarski, Robert F. Bentley, Tayler A. Buchan, Felipe Homem Valle, Stephen P. Wright , et al. · 2023

Exercise imposes increased pulmonary vascular afterload based on rises in pulmonary artery (PA) wedge pressure, declines in PA compliance, and resistance‐compliance time. In health, afterload stress stabilizes during steady‐state exercise.…

Corrigendum to“Quercetin alleviates kainic acid-induced seizure by inhibiting the Nrf2-mediated ferroptosis pathway” [Free Radic. Biol. Med. 191 (2022) 212–226] Open

Ruijin Xie, Wenjing Zhao, Scott Lowe, Robert F. Bentley, Guoqin Hu , et al. · 2022

SEX DIFFERENCES IN PULMONARY AND SYSTEMIC VASCULAR FUNCTION AT REST AND DURING EXERCISE IN HEALTHY OLDER ADULTS Open

R. Sless, S. Wright, Robert F. Bentley, F. Valle, S. Mak · 2022

BALLISTOCARDIOGRAPHY TO CHARACTERIZE PULMONARY ARTERY PRESSURE IN ADVANCED HEART FAILURE PATIENTS AND HEALTHY ADULTS Open

I. Chang, Sinan Osman, Robert F. Bentley, A. Mihailidis, Susanna Mak · 2022

Quercetin alleviates kainic acid-induced seizure by inhibiting the Nrf2-mediated ferroptosis pathway Open

Ruijin Xie, Wenjing Zhao, Scott Lowe, Robert F. Bentley, Guoqin Hu , et al. · 2022

These findings indicated that quercetin effectively protects against seizure-induced neuron death in vivo and in vitro and alleviates cognitive function impairment via the SIRT1/Nrf2/SLC7A11/GPX4 pathway.

Sex differences in pulmonary and systemic vascular function at rest and during exercise in healthy older adults Open

Ryan T. Sless, Stephen P. Wright, Robert F. Bentley, Felipe Homem Valle, Susanna Mak · 2022

Our aim was to conduct a sex-disaggregated analysis of pulmonary and systemic vascular function in healthy individuals both at rest and during submaximal exercise. Healthy individuals underwent right-heart catheterization at rest and durin…

The role of exercise right heart catheterization to guide pulmonary hypertension therapy in older adults Open

Susanna Mak, Shimon Kolker, Natasha R. Girdharry, Robert F. Bentley, Felipe Homem Valle , et al. · 2022

The spectrum of patients referred for suspected pulmonary arterial hypertension (PAH) includes a population with clinical features suggestive of pulmonary hypertension due to left heart disease (PH‐LHD). Even after right heart catheterizat…

Atrial structure and function in middle‐aged, physically‐active males and females: A cardiac magnetic resonance study Open

Meghan Glibbery, Laura Banks, Mustafa A. Altaha, Robert F. Bentley, Kaja M. Konieczny , et al. · 2021

Recent studies have reported on an association between endurance sport, atrial enlargement and the development of lone atrial fibrillation in younger, male cohorts. The atrial morphology and function of middle‐aged, physically‐active males…

A Novel Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Biomarker—Anti-DSG2—Is Absent in Athletes With Right Ventricular Enlargement Open

David Dorian, Diptendu Chatterjee, Kim A. Connelly, Jack M. Goodman, Andrew T. Yan , et al. · 2021

Body Habitus Considerations During Right Heart Catheterization Open

Natasha R. Girdharry, Robert F. Bentley, Felipe Homem Valle, E. Karvasarski, Sinan Osman , et al. · 2021

Temporal Patterns of Pulmonary Vascular Loading during Exercise in Patients with Pre versus Post Capillary Pulmonary Hypertension Open

E. Karvasarski, Robert F. Bentley, Tayler A. Buchan, Felipe Homem Valle, Stephen P. Wright , et al. · 2021

Measures of Right Ventricular Afterload Predict Exercise Pulmonary Hypertension beyond Mean Pulmonary Artery Pressure Open

Sinan Osman, Robert F. Bentley, Susanna Mak · 2021

Exercise Right Heart Catheterisation in Cardiovascular Diseases: A Guide to Interpretation and Considerations in the Management of Valvular Heart Disease Open

Felipe Homem Valle, Basma Mohammed, Stephen P. Wright, Robert F. Bentley, Neil Fam , et al. · 2021

The use of exercise right heart catheterisation for the assessment of cardiovascular diseases has regained attention recently. Understanding physiologic haemodynamic exercise responses is key for the identification of abnormal haemodynamic…

Normal and Abnormal Relationships of Pulmonary Artery to Wedge Pressure During Exercise Open

Robert F. Bentley, Madeleine Barker, S. Esfandiari, Stephen P. Wright, Felipe Homem Valle , et al. · 2020

Background Resting right heart catheterization can assess both left heart filling and pulmonary artery (PA) pressures to identify and classify pulmonary hypertension. Although exercise may further elucidate hemodynamic abnormalities, curre…

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