Robert Foerster
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View article: Divergent Prognostic Value of Primary Tumor Segmentation Metrics on Baseline FDG PET/CT in Colorectal Cancer
Divergent Prognostic Value of Primary Tumor Segmentation Metrics on Baseline FDG PET/CT in Colorectal Cancer Open
Background: Colorectal cancer (CRC) remains a major global health concern, with increasing incidence and mortality projected over the coming decades. Despite the central role of staging systems, substantial heterogeneity in clinical outcom…
View article: A comprehensive multifaceted technical evaluation framework for implementation of auto-segmentation models in radiotherapy
A comprehensive multifaceted technical evaluation framework for implementation of auto-segmentation models in radiotherapy Open
The framework provides a robust method for validating automatic segmentation models in radiotherapy. However, establishing standardized benchmarks and consensus guidelines within the radiotherapy community remains essential for proper clin…
View article: Tumor Segmentation on PSMA PET/CT Predicts Survival in Biochemical Recurrence of Prostate Cancer: A Retrospective Study Using [68Ga]Ga-PSMA-11 and [18F]-PSMA-1007
Tumor Segmentation on PSMA PET/CT Predicts Survival in Biochemical Recurrence of Prostate Cancer: A Retrospective Study Using [68Ga]Ga-PSMA-11 and [18F]-PSMA-1007 Open
Background: PSMA PET/CT imaging has become a cornerstone in the management of prostate cancer, particularly in the setting of biochemical recurrence (BCR). While semi-quantitative parameters such as SUVmean have been evaluated as prognosti…
View article: Reasoning Models for Text Mining in Oncology – a Comparison Between o1 Preview and GPT-4o
Reasoning Models for Text Mining in Oncology – a Comparison Between o1 Preview and GPT-4o Open
Purpose Chain-of-thought prompting is a method to make a Large Language Model (LLM) generate intermediate reasoning steps when solving a complex problem to increase its performance. OpenAI’s o1 preview is an LLM that has been trained with …
View article: SMILE—stereotactic multiple fraction radiotherapy for non-spine bone metastases: study protocol for a multicenter, open-label phase III randomized controlled trial
SMILE—stereotactic multiple fraction radiotherapy for non-spine bone metastases: study protocol for a multicenter, open-label phase III randomized controlled trial Open
The trial has been registered prospectively on ClinicalTrials.gov under the identifier NCT05406063, as of May 3, 2022.
View article: Study Protocol: SMILE - Stereotactic Multiple Fraction Radiotherapy for Non-Spine Bone Metastases
Study Protocol: SMILE - Stereotactic Multiple Fraction Radiotherapy for Non-Spine Bone Metastases Open
Background: The SMILE study addresses a significant need in palliative oncology by evaluating the non-inferiority of a shortened, 3-fraction stereotactic body radiotherapy (SBRT) schedule against the traditional 5-fraction approach for non…
View article: The Impact of the Temperature on Extracting Information From Clinical Trial Publications Using Large Language Models
The Impact of the Temperature on Extracting Information From Clinical Trial Publications Using Large Language Models Open
Introduction The application of natural language processing (NLP) for extracting data from biomedical research has gained momentum with the advent of large language models (LLMs). However, the effect of different LLM parameters, such as te…
View article: An Innovative Non-Linear Prediction Model for Clinical Benefit in Women with Newly Diagnosed Breast Cancer Using Baseline FDG-PET/CT and Clinical Data
An Innovative Non-Linear Prediction Model for Clinical Benefit in Women with Newly Diagnosed Breast Cancer Using Baseline FDG-PET/CT and Clinical Data Open
Objectives: We aimed to develop a novel non-linear statistical model integrating primary tumor features on baseline [18F]-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT), molecular subtype, and clinical dat…
View article: Predictive Value of Total Metabolic Tumor Burden Prior to Treatment in NSCLC Patients Treated with Immune Checkpoint Inhibition
Predictive Value of Total Metabolic Tumor Burden Prior to Treatment in NSCLC Patients Treated with Immune Checkpoint Inhibition Open
Objectives: We aimed to assess the predictive value of the total metabolic tumor burden prior to treatment in patients with advanced non-small-cell lung cancer (NSCLC) receiving immune checkpoint inhibitors (ICIs). Methods: Pre-treatment 2…
View article: Additional Primary Tumors Detected Incidentally on FDG PET/CT at Staging in Patients with First Diagnosis of NSCLC: Frequency, Impact on Patient Management and Survival
Additional Primary Tumors Detected Incidentally on FDG PET/CT at Staging in Patients with First Diagnosis of NSCLC: Frequency, Impact on Patient Management and Survival Open
We aimed to assess the frequency of additional primary malignancies detected incidentally on [18F]fluoro-D-glucose positron emission tomography/computed tomography (FDG-PET/CT) at staging in NSCLC patients. Moreover, their impact on patien…
View article: Predictive Value of Baseline FDG-PET/CT for the Durable Response to Immune Checkpoint Inhibition in NSCLC Patients Using the Morphological and Metabolic Features of Primary Tumors
Predictive Value of Baseline FDG-PET/CT for the Durable Response to Immune Checkpoint Inhibition in NSCLC Patients Using the Morphological and Metabolic Features of Primary Tumors Open
Objectives: We aimed to investigate the predictive value of baseline 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography/computed tomography (FDG-PET/CT) for durable responses to immune checkpoint inhibitors (ICIs) by linking the …
View article: Sex-Related Differences in Metastatic Melanoma Patients Treated with Immune Checkpoint Inhibition
Sex-Related Differences in Metastatic Melanoma Patients Treated with Immune Checkpoint Inhibition Open
Objectives: We aimed to investigate sex-related differences in patients with advanced melanoma treated with ICI by linking the assessment of inflammatory response in peripheral blood, onset of immune-related adverse events IRAEs during the…
View article: Inflammatory Blood Parameters as Biomarkers for Response to Immune Checkpoint Inhibition in Metastatic Melanoma Patients
Inflammatory Blood Parameters as Biomarkers for Response to Immune Checkpoint Inhibition in Metastatic Melanoma Patients Open
Objectives: We aimed to investigate whether inflammatory parameters in peripheral blood at baseline and during the first six months of treatment could predict the short- and long-term outcomes of metastatic melanoma patients treated with i…
View article: Improved Survival Prediction by Combining Radiological Imaging and S-100B Levels Into a Multivariate Model in Metastatic Melanoma Patients Treated With Immune Checkpoint Inhibition
Improved Survival Prediction by Combining Radiological Imaging and S-100B Levels Into a Multivariate Model in Metastatic Melanoma Patients Treated With Immune Checkpoint Inhibition Open
Purpose We explored imaging and blood bio-markers for survival prediction in a cohort of patients with metastatic melanoma treated with immune checkpoint inhibition. Materials and Methods 94 consecutive metastatic melanoma patients treated…
View article: Impact of peripheral angioplasty on wound oxygenation measured with near-infrared spectroscopy in patients with critical limb ischemia
Impact of peripheral angioplasty on wound oxygenation measured with near-infrared spectroscopy in patients with critical limb ischemia Open
Impact of peripheral angioplasty on wound oxygenation measured with near-infrared spectroscopy in patients with critical limb ischemia Abstract Background Near-infrared Spectroscopy (NIRS) has been proposed as a promising noninvasive tool …
View article: Preselection of robust radiomic features does not improve outcome modelling in non-small cell lung cancer based on clinical routine FDG-PET imaging
Preselection of robust radiomic features does not improve outcome modelling in non-small cell lung cancer based on clinical routine FDG-PET imaging Open
Background Radiomics is a promising tool for identifying imaging-based biomarkers. Radiomics-based models are often trained on single-institution datasets; however, multi-centre imaging datasets are preferred for external generalizability …
View article: Stereotactic Body Radiotherapy for High-Risk Prostate Cancer: A Systematic Review
Stereotactic Body Radiotherapy for High-Risk Prostate Cancer: A Systematic Review Open
Background: Radiotherapy (RT) is an established, potentially curative treatment option for all risk constellations of localized prostate cancer (PCA). Androgen deprivation therapy (ADT) and dose-escalated RT can further improve outcome in …
View article: Impact of CT convolution kernel on robustness of radiomic features for different lung diseases and tissue types
Impact of CT convolution kernel on robustness of radiomic features for different lung diseases and tissue types Open
Objectives: In this study, we aimed to assess the impact of different CT reconstruction kernels on the stability of radiomic features and the transferability between different diseases and tissue types. Three lung diseases were evaluated, …
View article: Dosimetric comparison of protons vs photons in re-irradiation of intracranial meningioma
Dosimetric comparison of protons vs photons in re-irradiation of intracranial meningioma Open
Objectives: Re-irradiation of recurrent intracranial meningiomas represents a major challenge due to dose limits of critical structures and the necessity of sufficient dose coverage of the recurrent tumor for local control. The aim of this…
View article: CT image standardization is superior to larger but heterogeneous data for robust radiomic models
CT image standardization is superior to larger but heterogeneous data for robust radiomic models Open
Background: Radiomics is a promising tool for identification of new prognostic biomarkers. Radiomic models are often based on single-institution data however multi-centric data, highly heterogeneous due to different scanning protocols, ref…
View article: Percutaneous parametrial dose escalation in women with advanced cervical cancer: feasibility and efficacy in relation to long-term quality of life
Percutaneous parametrial dose escalation in women with advanced cervical cancer: feasibility and efficacy in relation to long-term quality of life Open
Background We analyzed long-term quality of life (QoL) and prognostic factors for QoL as well as clinical outcome in patients with advanced cervical cancer (ACC) treated with primary radiochemotherapy (RChT) consisting of external beam rad…
View article: Bimodality treatment of patients with pelvic adenoid cystic carcinoma with photon intensity-modulated radiotherapy plus carbon ion boost: a case series
Bimodality treatment of patients with pelvic adenoid cystic carcinoma with photon intensity-modulated radiotherapy plus carbon ion boost: a case series Open
IMRT plus C12 ion boost as a definitive or adjuvant treatment for pelvic ACCs seems to be a promising therapeutic option. No unexpected toxicity was detected and the observed toxicity remained consistently low. The initial treatment respon…
View article: Survival and stability of patients with urothelial cancer and spinal bone metastases after palliative radiotherapy
Survival and stability of patients with urothelial cancer and spinal bone metastases after palliative radiotherapy Open
Background The aim of the study was to analyze survival and stability of patients with urothelial cell cancer and spinal bone metastases (SBM) after radiotherapy (RT). Furthermore, to assess the effects of RT on bone mineral density (BMD) …
View article: Survival and stability of patients with urothelial cancer and spinal bone metastases after palliative radiotherapy
Survival and stability of patients with urothelial cancer and spinal bone metastases after palliative radiotherapy Open
Background The aim of the study was to analyze survival and stability of patients with urothelial cell cancer and spinal bone metastases (SBM) after radiotherapy (RT). Furthermore, to assess the effects of RT on bone mineral density (BMD) …
View article: Outcome in patients with small cell lung cancer re-irradiated for brain metastases after prior prophylactic cranial irradiation
Outcome in patients with small cell lung cancer re-irradiated for brain metastases after prior prophylactic cranial irradiation Open
In conclusion, cerebral re-irradiation after prior PCI is beneficial for symptom palliation and is associated with minimal side effects in patients with SCLC. Our survival data suggests that it is primarily useful in patients with adequate…