Robert Goold
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View article: Therapeutic validation of MMR-associated genetic modifiers in a human ex vivo model of Huntington disease
Therapeutic validation of MMR-associated genetic modifiers in a human ex vivo model of Huntington disease Open
The pathological huntingtin (HTT) trinucleotide repeat underlying Huntington disease (HD) continues to expand throughout life. Repeat length correlates both with earlier age at onset (AaO) and faster progression, making slowing its expansi…
View article: Therapeutic validation of MMR-associated genetic modifiers in a human<i>ex vivo</i>model of Huntington’s disease
Therapeutic validation of MMR-associated genetic modifiers in a human<i>ex vivo</i>model of Huntington’s disease Open
The pathological huntingtin ( HTT ) trinucleotide repeat underlying Huntington’s disease (HD) continues to expand throughout life. Repeat length correlates both with earlier age at onset (AaO) and faster progression, making slowing its exp…
View article: FAN1 modifies Huntington’s disease progression by stabilizing the expanded <i>HTT</i> CAG repeat
FAN1 modifies Huntington’s disease progression by stabilizing the expanded <i>HTT</i> CAG repeat Open
Huntington's disease (HD) is an inherited neurodegenerative disease caused by an expanded CAG repeat in the huntingtin (HTT) gene. CAG repeat length explains around half of the variation in age at onset (AAO) but genetic variation elsewher…