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View article: Sleep need driven oscillation of glutamate synaptic phenotype
Sleep need driven oscillation of glutamate synaptic phenotype Open
Sleep loss increases AMPA-synaptic strength and number in the neocortex. However, this is only part of the synaptic sleep loss response. We report an increased AMPA/NMDA EPSC ratio in frontal-cortical pyramidal neurons of layers 2–3. Silen…
View article: Sleep need driven oscillation of glutamate synaptic phenotype
Sleep need driven oscillation of glutamate synaptic phenotype Open
Sleep loss increases AMPA-synaptic strength and number in the neocortex. However, this is only part of the synaptic sleep loss response. We report increased AMPA/NMDA EPSC ratio in frontal-cortical pyramidal neurons of layers 2-3. Silent s…
View article: Sleep need driven oscillation of glutamate synaptic phenotype
Sleep need driven oscillation of glutamate synaptic phenotype Open
Sleep loss increases AMPA-synaptic strength and number in the neocortex. However, this is only part of the synaptic sleep loss response. We report increased AMPA/NMDA EPSC ratio in frontal-cortical pyramidal neurons of layers 2-3. Silent s…
View article: An adenosinergic positive feedback loop extends pharmacological cardioprotection duration
An adenosinergic positive feedback loop extends pharmacological cardioprotection duration Open
Background and Purpose Adenosine receptor activation induces delayed, sustained cardioprotection against ischaemia–reperfusion (IR) injury (24–72 h), but the mechanisms underlying extended cardioprotection duration remain unresolved. We hy…
View article: Sleep need driven oscillation of glutamate synaptic phenotype
Sleep need driven oscillation of glutamate synaptic phenotype Open
Sleep loss increases AMPA-synaptic strength and number in the neocortex. However, this is only part of the synaptic sleep loss response. We report increased AMPA/NMDA EPSC ratio in frontal-cortical pyramidal neurons of layers 2-3. Silent s…
View article: Sleep need driven oscillation of glutamate synaptic phenotype
Sleep need driven oscillation of glutamate synaptic phenotype Open
Sleep loss increases AMPA-synaptic strength and number in the neocortex. However, this is only part of the synaptic sleep loss response. We report an increased AMPA/NMDA EPSC ratio in frontal-cortical pyramidal neurons of layers 2–3. Silen…
View article: Reviewer #1 (Public Review): Sleep need driven oscillation of glutamate synaptic phenotype
Reviewer #1 (Public Review): Sleep need driven oscillation of glutamate synaptic phenotype Open
Sleep loss increases AMPA-synaptic strength and number in the neocortex. However, this is only part of the synaptic sleep loss response. We report increased AMPA/NMDA EPSC ratio in frontal-cortical pyramidal neurons of layers 2-3. Silent s…
View article: Reviewer #2 (Public Review): Sleep need driven oscillation of glutamate synaptic phenotype
Reviewer #2 (Public Review): Sleep need driven oscillation of glutamate synaptic phenotype Open
Sleep loss increases AMPA-synaptic strength and number in the neocortex. However, this is only part of the synaptic sleep loss response. We report increased AMPA/NMDA EPSC ratio in frontal-cortical pyramidal neurons of layers 2-3. Silent s…
View article: Sleep need driven oscillation of glutamate synaptic phenotype
Sleep need driven oscillation of glutamate synaptic phenotype Open
Sleep loss increases AMPA-synaptic strength and number in the neocortex. However, this is only part of the synaptic sleep loss response. We report increased AMPA/NMDA EPSC ratio in frontal-cortical pyramidal neurons of layers 2-3. Silent s…
View article: Dihydropyridine calcium blockers do not interfere with non-rapid eye movement sleep
Dihydropyridine calcium blockers do not interfere with non-rapid eye movement sleep Open
Non-rapid eye movement (NREM) sleep is tightly homeostatically regulated and essential for survival. In the electroencephalogram (EEG), oscillations in the delta (0.5–4 Hz) range are prominent during NREM sleep. These delta oscillations ar…
View article: Arousal-Mediated Sleep Disturbance Persists During Cocaine Abstinence in Male Mice
Arousal-Mediated Sleep Disturbance Persists During Cocaine Abstinence in Male Mice Open
Acute cocaine disturbs sleep on a dose-dependent basis; however, the consequences of chronic cocaine remain unclear. While the arousal promotion following cocaine has been well-established, effects of cocaine on sleep after termination of …
View article: 0027 Reciprocal Modulation of Cortical Excitatory and Inhibitory Synapses by Wake-Sleep Homeostatic State
0027 Reciprocal Modulation of Cortical Excitatory and Inhibitory Synapses by Wake-Sleep Homeostatic State Open
Introduction A widely debated function of sleep involves a homeostatic program of down-regulation of excitatory synaptic strength following an overall increase during the preceding waking period, preserving however the previously existing …
View article: Sleep Deprivation Enhances Cocaine Conditioned Place Preference in an Orexin Receptor-Modulated Manner
Sleep Deprivation Enhances Cocaine Conditioned Place Preference in an Orexin Receptor-Modulated Manner Open
Drug addiction and withdrawal are characterized by sleep disruption, but the effects of sleep disruption on these states are not well characterized. Sleep deprivation (SD) immediately before the cocaine conditioning trials enhanced cocaine…
View article: Sleeping Sickness Disrupts the Sleep-Regulating Adenosine System
Sleeping Sickness Disrupts the Sleep-Regulating Adenosine System Open
Patients with sleeping sickness, caused by the parasite Trypanosoma brucei , have disruptions in both sleep timing and sleep architecture. However, the underlying cause of these sleep disturbances is not well understood. Here, we assessed …
View article: An essential role for MEF2C in the cortical response to loss of sleep in mice
An essential role for MEF2C in the cortical response to loss of sleep in mice Open
Neuronal activity and gene expression in response to the loss of sleep can provide a window into the enigma of sleep function. Sleep loss is associated with brain differential gene expression, an increase in pyramidal cell mEPSC frequency …
View article: Author response: An essential role for MEF2C in the cortical response to loss of sleep in mice
Author response: An essential role for MEF2C in the cortical response to loss of sleep in mice Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Neuronal activity and gene expression in r…
View article: Structure of cortical network activity across natural wake and sleep states in mice
Structure of cortical network activity across natural wake and sleep states in mice Open
Cortical neurons fire intermittently and synchronously during non-rapid eye movement sleep (NREMS), in which active and silent periods are referred to as ON and OFF periods, respectively. Neuronal firing rates during ON periods (NREMS-ON-a…
View article: Development of a high temperature pyrolysis mechanism for cyclopentanone, a potential biofuel derived from biomass
Development of a high temperature pyrolysis mechanism for cyclopentanone, a potential biofuel derived from biomass Open
Cyclopentanone (CPO) is a promising biofuel for spark-ignition engines due to its ring strain and high auto-ignition resistance. The Department of Energy has identified CPO as a potential biofuel candidate because of its unique chemical pr…
View article: Loss of <i>Arc</i> attenuates the behavioral and molecular responses for sleep homeostasis in mice
Loss of <i>Arc</i> attenuates the behavioral and molecular responses for sleep homeostasis in mice Open
Significance Arc is a neural immediate early gene involved in synaptic downscaling and is robustly induced by prolonged wakefulness in rodent brains. However, it remains unclear if and how Arc is involved in sleep regulation. Here we find …
View article: An essential role for MEF2C in the cortical response to loss of sleep
An essential role for MEF2C in the cortical response to loss of sleep Open
Neuronal activity and gene expression in response to the loss of sleep can provide a window into the enigma of sleep function. Sleep loss is associated with brain differential gene expression, an increase in pyramidal cell mEPSC frequency …
View article: Enhanced cortical responsiveness during natural sleep in freely behaving mice
Enhanced cortical responsiveness during natural sleep in freely behaving mice Open
Cortical networks exhibit large shifts in spontaneous dynamics depending on the vigilance state. Waking and rapid eye movement (REM) sleep are characterized by ongoing irregular activity of cortical neurons while during slow wave sleep (SW…