Robert J. Hall
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View article: Genomic Locus Tagged by Lung Function <scp>GWAS SNV</scp> rs12477314 (2q37.3) Acts as a Regulatory Region for a Systemic Inflammatory Phenotype
Genomic Locus Tagged by Lung Function <span>GWAS SNV</span> rs12477314 (2q37.3) Acts as a Regulatory Region for a Systemic Inflammatory Phenotype Open
SNV rs12477314 (C>T; 1000G MAF = 0.14), which maps to an intergenic region on 2q37.3, is a genome‐wide significant association signal for pulmonary function in genome‐wide association study meta‐analyses. Bioinformatic analysis revealed th…
View article: The role of the <i>ADRB2</i> Thr164Ile variant in lung function determination, plasma proteome variability and other phenotypes in UK Biobank
The role of the <i>ADRB2</i> Thr164Ile variant in lung function determination, plasma proteome variability and other phenotypes in UK Biobank Open
Introduction The effect of coding polymorphisms of the β 2 -adrenergic receptor gene ( ADRB2 ) on functional properties of the receptor is well established. We recently reported a genome-wide significant association between Thr164Ile and l…
View article: The role of the<i>ADRB2</i>Thr164Ile variant in lung function determination, plasma proteome variability and other phenotypes in UK Biobank
The role of the<i>ADRB2</i>Thr164Ile variant in lung function determination, plasma proteome variability and other phenotypes in UK Biobank Open
Introduction The effect of coding polymorphisms of the beta-2 adrenergic receptor gene ( ADRB2 ) on functional properties of the receptor is well-established. We recently reported a genome-wide significant association between Thr164Ile and…
View article: Mepolizumab-induced Changes in Nasal Methylome and Transcriptome to Predict Response in Asthma
Mepolizumab-induced Changes in Nasal Methylome and Transcriptome to Predict Response in Asthma Open
"Mepolizumab Induced Changes in Nasal Methylome and Transcriptome to Predict Response in Asthma." American Journal of Respiratory and Critical Care Medicine, 0(ja), pp.
View article: Nepalese indoor cookstove smoke extracts alter human airway epithelial gene expression, DNA methylation and hydroxymethylation
Nepalese indoor cookstove smoke extracts alter human airway epithelial gene expression, DNA methylation and hydroxymethylation Open
Household air pollution caused by inefficient cooking practices causes 4 million deaths a year worldwide. In Nepal, 86% of the rural population use solid fuels for cooking. Over 25% of premature deaths associated with air pollution are res…
View article: Genome-wide association study of chronic sputum production implicates loci involved in mucus production and infection
Genome-wide association study of chronic sputum production implicates loci involved in mucus production and infection Open
Background Chronic sputum production impacts on quality of life and is a feature of many respiratory diseases. Identification of the genetic variants associated with chronic sputum production in a disease agnostic sample could improve unde…
View article: Mepolizumab induced changes in nasal methylome and transcriptome to predict response in asthma
Mepolizumab induced changes in nasal methylome and transcriptome to predict response in asthma Open
Rationale Mepolizumab is effective for a subset of severe asthma patients in reducing exacerbation frequency. Discovery of a predictive/early marker accurately identifying patients that will have a long-term beneficial clinical response wo…
View article: Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk
Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk Open
Lung-function impairment underlies chronic obstructive pulmonary disease (COPD) and predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of lung function to date, comprising 588,452 participants, we ident…
View article: Pericardial Effusion: A Novel Presentation of Aplastic Anemia
Pericardial Effusion: A Novel Presentation of Aplastic Anemia Open
Pericardial effusion is defined as the accumulation of fluid between the visceral and parietal pericardium. The underlying etiology varies as any pathology that causes pericarditis or involves the pericardium can cause effusion. In practic…
View article: Multi-ancestry genome-wide association study improves resolution of genes, pathways and pleiotropy for lung function and chronic obstructive pulmonary disease
Multi-ancestry genome-wide association study improves resolution of genes, pathways and pleiotropy for lung function and chronic obstructive pulmonary disease Open
Lung function impairment underlies chronic obstructive pulmonary disease (COPD) and predicts mortality. In the largest multi-ancestry GWAS meta-analysis of lung function to date, comprising 580,869 participants, 1020 independent associatio…
View article: Genome-wide association study of chronic sputum production implicates loci involved in mucus production and infection
Genome-wide association study of chronic sputum production implicates loci involved in mucus production and infection Open
Background Chronic sputum production impacts on quality of life and is a feature of many respiratory diseases. Identification of the genetic variants associated with chronic sputum production in a disease agnostic sample could improve unde…
View article: Functional genomics of GPR126 in airway smooth muscle and bronchial epithelial cells
Functional genomics of GPR126 in airway smooth muscle and bronchial epithelial cells Open
GPR126 is an adhesion G protein‐coupled receptor which lies on chromosome 6q24. Genetic variants in this region are reproducibly associated with lung function and COPD in genome wide association studies (GWAS). The aims of this study were …
View article: Extended lifespan of bronchial epithelial cells maintains normal cellular phenotype and transcriptome integrity
Extended lifespan of bronchial epithelial cells maintains normal cellular phenotype and transcriptome integrity Open
Genetic studies have identified several epithelial-derived genes associated with airway diseases. However, techniques used to study gene function frequently exceed the proliferative potential of primary human bronchial epithelial cells (HB…
View article: Genetic risk factors for the development of pulmonary disease identified by genome‐wide association
Genetic risk factors for the development of pulmonary disease identified by genome‐wide association Open
Chronic respiratory diseases are a major cause of morbidity and mortality. Asthma and chronic obstructive pulmonary disease (COPD) combined affect over 500 million people worldwide. While environmental factors are important in disease prog…
View article: Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets
Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets Open
Chronic obstructive pulmonary disease (COPD) is characterized by reduced lung function and is the third leading cause of death globally. Through genome-wide association discovery in 48,943 individuals, selected from extremes of the lung fu…
View article: List of Contents
List of Contents Open
Does a reduction in intrathecal opioid dose improve
View article: In Memoriam: Ali Massumi, MD (1945–2015)
In Memoriam: Ali Massumi, MD (1945–2015) Open
Dr. Ali Massumi died on 13 March 2015, surrounded by his family at Baylor–St. Luke's Medical Center Hospital in Houston, where he had pioneered the development of clinical electrophysiology (EP) therapy during a dedicated career of nearly …