Jean‐Robert Harlé
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View article: Determinants of social participation in patients living with systemic lupus erythematosus: the Psy-LUP multicentre study
Determinants of social participation in patients living with systemic lupus erythematosus: the Psy-LUP multicentre study Open
Objective Systemic lupus erythematosus (SLE) can negatively impact patients’ social participation. The aim of this study was to identify the determinants of social participation in patients with SLE. Methods A cross-sectional evaluation wa…
View article: Heart and systemic sclerosis—findings from a national cohort study
Heart and systemic sclerosis—findings from a national cohort study Open
Objectives Heart involvement is one of the leading causes of death in SSc. The prevalence of SSc-related cardiac involvement is poorly known. Our objective was to investigate the prevalence and prognosis burden of different heart diseases …
View article: POS1283 HEART AND SYSTEMIC SCLEROSIS – FINDINGS FROM NATIONAL COHORT STUDY
POS1283 HEART AND SYSTEMIC SCLEROSIS – FINDINGS FROM NATIONAL COHORT STUDY Open
Background Heart involvement is one of the leading causes of death in systemic sclerosis (SSc). Cardiac manifestations are heterogeneous. In particular, prevalence of SSc-related cardiopathy is poorly known due to a lack of consensus in it…
View article: Quantification of Antifibrillarin (anti-U3 RNP) Antibodies: A New Insight for Patients with Systemic Sclerosis
Quantification of Antifibrillarin (anti-U3 RNP) Antibodies: A New Insight for Patients with Systemic Sclerosis Open
Background: The detection of additional autoantibodies is of great concern in systemic sclerosis (SSc) when those included in the ACR/EULAR classification are negative. In this context, the interest of antifibrillarin (anti-U3RNP) autoanti…
View article: Functional and genetic testing in adults with HLH reveals an inflammatory profile rather than a cytotoxicity defect
Functional and genetic testing in adults with HLH reveals an inflammatory profile rather than a cytotoxicity defect Open
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory condition. Primary HLH occurs early in life as a result of monogenic biallelic mutations affecting lymphocyte cytotoxicity. Secondary HLH occurs mostly in adu…
View article: Early trajectories of skin thickening are associated with severity and mortality in systemic sclerosis
Early trajectories of skin thickening are associated with severity and mortality in systemic sclerosis Open
Background Systemic sclerosis (SSc) is a severe and highly heterogeneous disease. The modified Rodnan skin score (mRSS) is a widely used tool for the assessment of the extent and degree of skin thickness. This study aimed to identify the c…
View article: Intra-venous bevacizumab in hereditary hemorrhagic telangiectasia (HHT): A retrospective study of 46 patients
Intra-venous bevacizumab in hereditary hemorrhagic telangiectasia (HHT): A retrospective study of 46 patients Open
Intravenous bevacizumab seems to provide a clinical benefice in severe HHT patients. Precautions concerning wound healing and vascular pathologies must be respected. Prospective double blinded versus placebo trials are needed.
View article: Pulmonary hypertension subtypes associated with hereditary haemorrhagic telangiectasia: Haemodynamic profiles and survival probability
Pulmonary hypertension subtypes associated with hereditary haemorrhagic telangiectasia: Haemodynamic profiles and survival probability Open
This study revealed the diversity of PH mechanisms in HHT. The description of combined post- and pre-capillary PH with/or without high cardiac output (CO) suggests either a continuum between the pre- and post-capillary haemodynamic profile…
View article: Long-term efficacy and safety of rituximab in IgG4-related disease: Data from a French nationwide study of thirty-three patients
Long-term efficacy and safety of rituximab in IgG4-related disease: Data from a French nationwide study of thirty-three patients Open
RTX is effective for both induction therapy and treatment of relapses in IgG4-RD, but relapses are frequent after B-cell reconstitution. Maintenance therapy with systematic RTX infusions is associated with longer relapse-free survival and …
View article: Intérêt D’une Recherche De Thrombophilie Au Cours Des Thromboses De La Veine Porte Dans Un Service De Médecine Interne
Intérêt D’une Recherche De Thrombophilie Au Cours Des Thromboses De La Veine Porte Dans Un Service De Médecine Interne Open
Background: Many causes of portal vein thrombosis are described and most patients had a combination of local and systemic risk factors. In many studies, prtothombotic disorders investigations were conducted in various departments of haemat…
View article: T Cell Polarization toward TH2/TFH2 and TH17/TFH17 in Patients with IgG4-Related Disease
T Cell Polarization toward TH2/TFH2 and TH17/TFH17 in Patients with IgG4-Related Disease Open
IgG4-related disease (IgG4-RD) is a fibro-inflammatory disorder involving virtually every organ with a risk of organ dysfunction. Despite recent studies regarding B cell and T cell compartments, the disease's pathophysiology remains poorly…
View article: Ophthalmic manifestations in IgG4-related disease
Ophthalmic manifestations in IgG4-related disease Open
IgG4-related disease (IgG4-RD) is characterized by variable tissue or organ involvements sharing common pathological findings. Orbital or orbital adnexa involvement of the disease has been reported in a few case series. The aim of our stud…
View article: Effect of Bevacizumab Nasal Spray on Epistaxis Duration in Hereditary Hemorrhagic Telangectasia
Effect of Bevacizumab Nasal Spray on Epistaxis Duration in Hereditary Hemorrhagic Telangectasia Open
clinicaltrials.gov Identifier: NCT02106520.
View article: Sarcoidosis Occurring After Solid Cancer
Sarcoidosis Occurring After Solid Cancer Open
The association between cancer and sarcoidosis is controversial. Some epidemiological studies show an increase of the incidence of cancer in patients with sarcoidosis but only few cases of sarcoidosis following cancer treatment have been r…