Robert Hemke
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View article: Na[18F]F PET/CT quantification in spondyloarthritis: comparative evaluation of SUV normalization approaches
Na[18F]F PET/CT quantification in spondyloarthritis: comparative evaluation of SUV normalization approaches Open
Background Sodium [ 18 F]Fluoride Positron Emission Tomography (Na[ 18 F]F PET) is a promising imaging biomarker for evaluating bone metabolism in spondyloarthritis (SpA) and other bone affecting diseases. Accurate quantification of tracer…
View article: Assessing Pediatric Pelvic Fracture Patterns: New Insights and Unique Fracture Characteristics
Assessing Pediatric Pelvic Fracture Patterns: New Insights and Unique Fracture Characteristics Open
Background: Pediatric pelvic ring fractures are different in biomechanics and anatomy compared with adults. Existing classification systems are insufficient in assessing the mechanical stability of these fractures due to a variety of reaso…
View article: High‐Resolution 3D Turbo Spin‐Echo Wrist MRI at 7T Accelerated by Compressed Sensing
High‐Resolution 3D Turbo Spin‐Echo Wrist MRI at 7T Accelerated by Compressed Sensing Open
This study aimed to obtain high‐resolution 3D isotropic turbo spin‐echo (TSE) wrist MRI acquisitions at 7T, with and without fat suppression, facilitated by compressed‐sensing (CS) acceleration. In 16 healthy subjects, fat‐suppressed (FS) …
View article: Prevalence of femoral condyle injuries in the setting of tibial plateau fractures
Prevalence of femoral condyle injuries in the setting of tibial plateau fractures Open
IV.
View article: Association of computed tomography‐derived body composition and complications after colorectal cancer surgery: A systematic review and meta‐analysis
Association of computed tomography‐derived body composition and complications after colorectal cancer surgery: A systematic review and meta‐analysis Open
The prediction of the risk of developing complications after colorectal surgery for colorectal carcinoma remains imprecise. Body composition measurements on a computed tomography (CT) scan can potentially contribute to a better preoperativ…
View article: AI in radiological imaging of soft-tissue and bone tumours: a systematic review evaluating against CLAIM and FUTURE-AI guidelines
AI in radiological imaging of soft-tissue and bone tumours: a systematic review evaluating against CLAIM and FUTURE-AI guidelines Open
Soft-tissue and bone tumours (STBT) are rare, diagnostically challenging lesions with variable clinical behaviours and treatment approaches. This systematic review provides an overview of Artificial Intelligence (AI) methods using radiolog…
View article: Does regional implementation of a clinical pathway for older adult patients with pelvic fragility fractures after low-energy trauma improve patient outcomes (PELVIC): a multicentre, stepped-wedge, randomised controlled trial
Does regional implementation of a clinical pathway for older adult patients with pelvic fragility fractures after low-energy trauma improve patient outcomes (PELVIC): a multicentre, stepped-wedge, randomised controlled trial Open
Introduction Patients with pelvic fragility fractures suffer from high morbidity and mortality rates. Despite the high incidence, there is currently no regional or nationwide treatment protocol which results in a wide variety of clinical p…
View article: Radiographic assessment of calcaneal fractures; A new approach to Böhler’s angle using computed tomography
Radiographic assessment of calcaneal fractures; A new approach to Böhler’s angle using computed tomography Open
III, Retrospective.
View article: Pulmonary herpes simplex virus and cytomegalovirus in patients with acute respiratory distress syndrome related to COVID-19
Pulmonary herpes simplex virus and cytomegalovirus in patients with acute respiratory distress syndrome related to COVID-19 Open
In mechanically ventilated COVID-19 patients, HSV reactivations are common, while CMV reactivations were rare. HSV viral load dynamics prior to or without antiviral treatment are associated with mortality. Alveolar inflammation is elevated…
View article: The effect of immunosuppressive therapies on the endothelial host response in critically ill COVID-19 patients
The effect of immunosuppressive therapies on the endothelial host response in critically ill COVID-19 patients Open
While several effective therapies for critically ill patients with COVID-19 have been identified in large, well-conducted trials, the mechanisms underlying these therapies have not been investigated in depth. Our aim is to investigate the …
View article: Impact of bimekizumab and certolizumab pegol on efficacy, safety and osteoblastic activity in radiographic axial spondyloarthritis: results from a phase IIa, multicentre, randomised, double-blind, exploratory study with PET-CT imaging
Impact of bimekizumab and certolizumab pegol on efficacy, safety and osteoblastic activity in radiographic axial spondyloarthritis: results from a phase IIa, multicentre, randomised, double-blind, exploratory study with PET-CT imaging Open
Background: The efficacy and safety of bimekizumab (BKZ), an inhibitor of interleukin (IL)-17F in addition to IL-17A, has been established in axial spondyloarthritis (axSpA). Early assessment of new bone formation is possible using 18 F-fl…
View article: Host Response Changes and Their Association with Mortality in COVID-19 Patients with Lymphopenia
Host Response Changes and Their Association with Mortality in COVID-19 Patients with Lymphopenia Open
Rationale: Lymphopenia in coronavirus disease (COVID-19) is associated with increased mortality. Objectives: To explore the association between lymphopenia, host response aberrations, and mortality in patients with lymphopenic COVID-19. Me…
View article: Advanced Magnetic Resonance Imaging and Molecular Imaging of the Painful Knee
Advanced Magnetic Resonance Imaging and Molecular Imaging of the Painful Knee Open
Chronic knee pain is a common condition. Causes of knee pain include trauma, inflammation, and degeneration, but in many patients the pathophysiology remains unknown. Recent developments in advanced magnetic resonance imaging (MRI) techniq…
View article: PB0671 Poor Correlation between Biomarkers and MRI-Detected Joint Damage in a Cross-Sectional Study of Persons with Non-Severe Hemophilia A
PB0671 Poor Correlation between Biomarkers and MRI-Detected Joint Damage in a Cross-Sectional Study of Persons with Non-Severe Hemophilia A Open
B. To start an early prophylaxis to avoid joint damage should be discussed even in patients with mild hemophilia.
View article: Platelets of COVID-19 patients display mitochondrial dysfunction, oxidative stress, and energy metabolism failure compatible with cell death
Platelets of COVID-19 patients display mitochondrial dysfunction, oxidative stress, and energy metabolism failure compatible with cell death Open
These data link energy metabolism failure in platelets from COVID-19 patients with a prothrombotic platelet phenotype with features matching cell death.
View article: Prolonged indoleamine 2,3-dioxygenase-2 activity and associated cellular stress in post-acute sequelae of SARS-CoV-2 infection
Prolonged indoleamine 2,3-dioxygenase-2 activity and associated cellular stress in post-acute sequelae of SARS-CoV-2 infection Open
None.
View article: Endothelial Permeability and the Angiopoietin/Tie2 System Following Mild and Severe COVID-19
Endothelial Permeability and the Angiopoietin/Tie2 System Following Mild and Severe COVID-19 Open
Endotheliopathy plays a role in the development of acute kidney and lung injury in COVID-19, probably due to inflammation, endothelial permeability, vascular leakage and edema formation. This study examined alterations in the circulation o…
View article: Age-related changes in plasma biomarkers and their association with mortality in COVID-19
Age-related changes in plasma biomarkers and their association with mortality in COVID-19 Open
Background Coronavirus disease 2019 (COVID-19)-induced mortality occurs predominantly in older patients. Several immunomodulating therapies seem less beneficial in these patients. The biological substrate behind these observations is unkno…
View article: Poor correlation between biomarkers and MRI-detected joint damage in a cross-sectional study of persons with nonsevere hemophilia A (DYNAMO study)
Poor correlation between biomarkers and MRI-detected joint damage in a cross-sectional study of persons with nonsevere hemophilia A (DYNAMO study) Open
In this study, selected biomarkers indicative of different aspects of hemophilic arthropathy showed no consistent correlation with IPSG scores. This suggests that systemically measured biomarkers are currently not suitable for identifying …
View article: Figure S6. from Fecal Microbiota Transplantation from Overweight or Obese Donors in Cachectic Patients with Advanced Gastroesophageal Cancer: A Randomized, Double-blind, Placebo-Controlled, Phase II Study
Figure S6. from Fecal Microbiota Transplantation from Overweight or Obese Donors in Cachectic Patients with Advanced Gastroesophageal Cancer: A Randomized, Double-blind, Placebo-Controlled, Phase II Study Open
Microbial genera plots
View article: Supplemental Materials from Fecal Microbiota Transplantation from Overweight or Obese Donors in Cachectic Patients with Advanced Gastroesophageal Cancer: A Randomized, Double-blind, Placebo-Controlled, Phase II Study
Supplemental Materials from Fecal Microbiota Transplantation from Overweight or Obese Donors in Cachectic Patients with Advanced Gastroesophageal Cancer: A Randomized, Double-blind, Placebo-Controlled, Phase II Study Open
Supplemental Materials