Robert H. Henning
YOU?
Author Swipe
View article: SUL-138 mitigates accelerated endothelial aging and protects the kidney
SUL-138 mitigates accelerated endothelial aging and protects the kidney Open
Vascular aging is marked by increased levels of reactive oxygen species in endothelial cells. Reactive oxygen species can, among others, be produced by dysfunctional mitochondria, contributing to acceleration of vascular aging by promoting…
View article: Time-Resolved Pump-Probe X-Ray Solution Scattering Capabilities at BioCARS 14 ID Beamline, Advanced Photon Source.
Time-Resolved Pump-Probe X-Ray Solution Scattering Capabilities at BioCARS 14 ID Beamline, Advanced Photon Source. Open
A fundamental problem in biological sciences is to connect biological function of a molecule with its structure. This is typically achieved by initiating a reaction in a biomolecule, and then following structural changes. Here we present t…
View article: Time-Resolved Macromolecular Crystallography Frontiers at BioCARS: Serial Laue Micro-Crystallography and Electric Field Jump
Time-Resolved Macromolecular Crystallography Frontiers at BioCARS: Serial Laue Micro-Crystallography and Electric Field Jump Open
BioCARS is a University of Chicago National User Facility with more than 25 years of scientific focus on synchrotron-based, dynamic studies in structural biology, initially using time-resolved protein crystallography and, more recently, ti…
View article: SUL-150 Limits Vascular Remodeling and Ventricular Failure in Pulmonary Arterial Hypertension
SUL-150 Limits Vascular Remodeling and Ventricular Failure in Pulmonary Arterial Hypertension Open
Pulmonary arterial hypertension (PAH) is a rare, progressive, and incurable disease characterized by an elevated pulmonary blood pressure, extensive remodeling of the pulmonary vasculature, increased pulmonary vascular resistance, and culm…
View article: Iron chelation prior to static cold storage decreases lipid peroxidation and improves gluconeogenesis during NMP in isolated porcine kidneys
Iron chelation prior to static cold storage decreases lipid peroxidation and improves gluconeogenesis during NMP in isolated porcine kidneys Open
Despite alternative graft preservation techniques, static cold storage (SCS) remains the most widely used kidney preservation method. Nevertheless, the molecular mechanisms of SCS' drawbacks remain poorly understood. One of the mechanisms …
View article: Mitochondrial proteomic adaptations to daily torpor in the Djungarian hamster (Phodopus sungorus)
Mitochondrial proteomic adaptations to daily torpor in the Djungarian hamster (Phodopus sungorus) Open
Hibernation is an adaptive strategy that conserves energy in response to environmental challenges. While mitochondrial proteomic adaptations are well-documented in deep hibernators, the proteomic changes underlying daily torpor remain less…
View article: Urinary Mitochondrial DNA Is Related to Allograft Function in Living Donor Kidney Transplantation—An Observational Study of the VAPOR-1 Cohort
Urinary Mitochondrial DNA Is Related to Allograft Function in Living Donor Kidney Transplantation—An Observational Study of the VAPOR-1 Cohort Open
Background: Ischemia–reperfusion injury (IRI) is a key contributor to graft dysfunction in kidney transplantation. Cell-free mitochondrial DNA (mtDNA) is increasingly recognized as a damage-associated molecular pattern (DAMP) and biomarker…
View article: Urinary Mitochondrial DNA Is Related to Allograft Function in Living Donor Kidney Transplantation, a Post-Hoc Analysis of the VAPOR-1 Study
Urinary Mitochondrial DNA Is Related to Allograft Function in Living Donor Kidney Transplantation, a Post-Hoc Analysis of the VAPOR-1 Study Open
Ischemia reperfusion injury (IRI) is the primary cause of early complications in kidney transplantation and contributes to impaired graft function. Mitochondrial DNA (mtDNA), which is implicated in IRI-induced organ damage, has shown promi…
View article: Time-Resolved Macromolecular Crystallography Frontiers at BioCARS: Serial Laue Micro-Crystallography and Electric Field Jump
Time-Resolved Macromolecular Crystallography Frontiers at BioCARS: Serial Laue Micro-Crystallography and Electric Field Jump Open
BioCARS is a University of Chicago National User Facility with more than 20 years of scientific focus on synchrotron-based, dynamic studies in structural biology, initially using time-resolved protein crystallography and, more recently, ti…
View article: Time-Resolved Pump-Probe X-Ray Solution Scattering Capabilities at BioCARS 14 ID Beamline, Advanced Photon Source.
Time-Resolved Pump-Probe X-Ray Solution Scattering Capabilities at BioCARS 14 ID Beamline, Advanced Photon Source. Open
An essential problem in biological sciences is to connect biological function of a molecule with its structure. This is typically achieved by initiating a reaction in a biomolecule, and then following structural changes by methods such as …
View article: Determining the Enzymatic Mechanism of DJ-1 Using a New Approach to Mix-and-Inject Synchrotron Serial Crystallography
Determining the Enzymatic Mechanism of DJ-1 Using a New Approach to Mix-and-Inject Synchrotron Serial Crystallography Open
Mix-and-inject serial crystallography (MISC) is a well established technique at X-ray Free Electron Lasers (XFELs) to capture snapshots of the progress of a reaction, typically between a protein and a ligand. Key to this method are special…
View article: SMC Abca1 and Abcg1 Deficiency Enhances Urinary Bladder Distension but Not Atherosclerosis
SMC Abca1 and Abcg1 Deficiency Enhances Urinary Bladder Distension but Not Atherosclerosis Open
BACKGROUND: Smooth muscle cells (SMCs) regulate blood flow distribution via vasoconstriction mediated by α-ARs (α-adrenergic receptors). Plasma membrane cholesterol accumulation affects α 1 -AR signaling and promotes loss of SMC contractil…
View article: Capturing the short-lived excited singlet state in crystals of a TADF silver( <scp>i</scp> ) complex
Capturing the short-lived excited singlet state in crystals of a TADF silver( <span>i</span> ) complex Open
Light-induced structural changes in a TADF-exhibiting silver( i ) complex were evaluated via time-resolved laser-pump/X-ray-probe Laue diffraction. LLCT leads to an asymmetric Ag atom shift in the short-lived S 1 singlet excited state.
View article: The modified 6-chromanol SUL-238 protects against accelerated vascular aging in vascular smooth muscle <i>Ercc1</i>-deficient mice
The modified 6-chromanol SUL-238 protects against accelerated vascular aging in vascular smooth muscle <i>Ercc1</i>-deficient mice Open
Introduction: Vascular aging is marked by increased mitochondrial reactive oxygen species (ROS) production, which leads to decreased nitric oxide (NO)-mediated vasodilation. Loss of NO can be partially compensated by endothelium-derived hy…
View article: Calorie restriction increases the sensitivity of progeroid Ercc1Δ/− mice to acute (neuro)inflammation
Calorie restriction increases the sensitivity of progeroid Ercc1Δ/− mice to acute (neuro)inflammation Open
Hospitalized elderly patients frequently suffer from delirium, especially in the context of sepsis-associated encephalopathy. Current treatments of delirium are merely symptomatic. Calorie restriction (CR) is both a promising strategy to p…
View article: Single-cell X-chromosome inactivation analysis links biased chimerism to differential gene expression and epigenetic erosion
Single-cell X-chromosome inactivation analysis links biased chimerism to differential gene expression and epigenetic erosion Open
Female cells randomly inactivate one X-chromosome, resulting in cellular mosaicism. Determining the bias in X-chromosomal inactivation (XCI) at single cell level may be relevant for understanding diseases prevalent in females. Here, we int…
View article: Editorial: Torpor and hibernation: metabolic and physiological paradigms
Editorial: Torpor and hibernation: metabolic and physiological paradigms Open
Keywords: heterothermy, seasonality, thermoregulation, body temperature, pathophysiology, mammals, primates, biomimicry (biomimetics)
View article: Deficiency of Abca1 and Abcg1 mediated cholesterol efflux pathways in smooth muscle cells enhances vasoconstriction but does not affect atherosclerosis
Deficiency of Abca1 and Abcg1 mediated cholesterol efflux pathways in smooth muscle cells enhances vasoconstriction but does not affect atherosclerosis Open
Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): VIDI grant from Netherlands Organization of Scientific Research (NWO). Rosalind Franklin Fellowship from the University Medic…
View article: Hippocampal neuroimmune response in mice undergoing serial daily torpor induced by calorie restriction
Hippocampal neuroimmune response in mice undergoing serial daily torpor induced by calorie restriction Open
Hibernating animals demonstrate a remarkable ability to withstand extreme physiological brain changes without triggering adverse neuroinflammatory responses. While hibernators may offer valuable insights into the neuroprotective mechanisms…
View article: Mild and deep hypothermia differentially affect cerebral neuroinflammatory and cold shock response following cardiopulmonary bypass in rat
Mild and deep hypothermia differentially affect cerebral neuroinflammatory and cold shock response following cardiopulmonary bypass in rat Open
TTM at 18 °C increased the neuroinflammatory response in amygdala and hippocampus compared to TTM at 33 °C in rats undergoing a CPB procedure. Additionally, TTM at 33 °C induced increased expression of TrkB and RBM3 in cortex and hippocamp…
View article: Mitochondrial Targeting against Alzheimer’s Disease: Lessons from Hibernation
Mitochondrial Targeting against Alzheimer’s Disease: Lessons from Hibernation Open
Alzheimer’s disease (AD) is the most common cause of dementia worldwide and yet remains without effective therapy. Amongst the many proposed causes of AD, the mitochondrial cascade hypothesis is gaining attention. Accumulating evidence sho…