Robert Hernandez
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View article: Impact of neuroanatomical alterations identified by advanced imaging on the diagnosis and management of schizophrenia: a systematic review of psychosocial interventions and pharmacological therapies
Impact of neuroanatomical alterations identified by advanced imaging on the diagnosis and management of schizophrenia: a systematic review of psychosocial interventions and pharmacological therapies Open
We aim to systematically evaluate neuroanatomical alterations identified through advanced imaging on the diagnosis and management of schizophrenia. Neuroimaging advancements of magnetic resonance imaging (MRI), positron emission tomography…
View article: Assessing the Difficulty and Long-Term Retention of Factual and Conceptual Knowledge Through Multiple-Choice Questions: A Longitudinal Study
Assessing the Difficulty and Long-Term Retention of Factual and Conceptual Knowledge Through Multiple-Choice Questions: A Longitudinal Study Open
These findings suggest conceptual/inferential thinking is more complex than rote memorization. However, the knowledge acquired is more durable in a longitudinal fashion, especially if it is reinforced in clinical settings.
View article: Silent Vanishing Lung Syndrome: Severe Emphysema in an Asymptomatic Patient
Silent Vanishing Lung Syndrome: Severe Emphysema in an Asymptomatic Patient Open
Vanishing lung syndrome (VLS) is an uncommon condition characterized by idiopathic giant bullous emphysema, resulting in the lungs appearing abnormally small on radiological scans. Some case reports have suggested a potential association b…
View article: Factors Affecting Motivation and Concentration of Engineering Students in Classrooms
Factors Affecting Motivation and Concentration of Engineering Students in Classrooms Open
Motivation, concentration and learning are highly complex aspects of student's behavior. The relationship between student concentration in a class and learning has been a prominent research topic in educational studies [1]. Motivation is a…
View article: Informal work in urban Mexico
Informal work in urban Mexico Open
This chapter presents a descriptive analysis of the labour market in urban Mexico, focusing on its heterogeneity across various employment status groups. It also studies the preferences of workers for formal wage-employment. About half of …
View article: Issue Information
Issue Information Open
5 years, where available.For other
View article: Clinician’s attitude towards clozapine prescription
Clinician’s attitude towards clozapine prescription Open
Introduction Current clinical guidelines recommend the use of clozapine for the treatment of refractory schizophrenia, present in up to a third of patients with this disease. Despite the evidence, the data point to low prescription, underd…
View article: Taxes, subsidies and gender gaps in hours and wages
Taxes, subsidies and gender gaps in hours and wages Open
Using microdata from 17 OECD countries, this paper documents a negative cross‐country correlation between gender gaps in market hours and wages. We find that the cross‐country differences in market hours are mostly accounted for by female …
View article: A Meta-Narrative Review of RUNX1-RUNX1T1 and its Relativity to CBF Disruption Within the Adult Population
A Meta-Narrative Review of RUNX1-RUNX1T1 and its Relativity to CBF Disruption Within the Adult Population Open
Acute Myeloid Leukemia (AML) is an aggressive subgroup of leukemias developed from a deviant hematopoietic stem cell, prevented from differentiating into a mature cell. Additionally, core binding factor (CBF) is disrupted by the translocat…
View article: Using Multiple Choice Questions to Evaluate the Difficulty and Long-Term Retention of Factual Versus Conceptual Knowledge
Using Multiple Choice Questions to Evaluate the Difficulty and Long-Term Retention of Factual Versus Conceptual Knowledge Open
Multiple choice questions (MCQs) are the mainstay of examinations for medical education, physician licensing, and board certification. MCQs are traditionally a preferred way to test rote recall of memorized facts. Their utility in assessin…
View article: Choices and Constraints: The Nature of Informal Employment in Urban Mexico
Choices and Constraints: The Nature of Informal Employment in Urban Mexico Open
Using a special module of the 2015 Mexican Labour Force Survey with information on workers’ preferences for jobs with social security coverage, it is found that 80 per cent of informal workers in large urban areas would prefer to work in a…
View article: Long-Term Outcomes of First-Admission Psychosis: A Naturalistic 21-Year Follow-Up Study of Symptomatic, Functional and Personal Recovery and Their Baseline Predictors
Long-Term Outcomes of First-Admission Psychosis: A Naturalistic 21-Year Follow-Up Study of Symptomatic, Functional and Personal Recovery and Their Baseline Predictors Open
This study was aimed at characterizing long-term outcomes of first-admission psychosis and examining their baseline predictors. Participants were assessed at baseline for 38 candidate predictors and re-assessed after a median follow-up of …
View article: 494 Phase 1 dose escalation and dose expansion study of an agonist redirected checkpoint (ARC) fusion protein, SL-279252 (PD1-Fc-OX40L), in subjects with advanced solid tumors or lymphomas
494 Phase 1 dose escalation and dose expansion study of an agonist redirected checkpoint (ARC) fusion protein, SL-279252 (PD1-Fc-OX40L), in subjects with advanced solid tumors or lymphomas Open
Background PD1-Fc-OX40L, is a hexameric, bi-functional fusion protein with an extracellular domain (ECD) of PD-1 (70 pM affinity to PD-L1) linked to the ECD of OX40L (324 pM affinity to OX40) through an Fc linker. The therapeutic activity …
View article: 3 Development of an integrated method to quantify receptor occupancy for agonist immunotherapeutics that stimulate target cells to migrate from the peripheral blood
3 Development of an integrated method to quantify receptor occupancy for agonist immunotherapeutics that stimulate target cells to migrate from the peripheral blood Open
Background One of the pharmacodynamic measures of biologic compounds is an assessment of target receptor/ligand occupancy (RO). If the primary mechanism for drug clearance is through target binding, drug exposure may increase once RO is sa…
View article: College Latino students : cultural integration, retention, and successful completion
College Latino students : cultural integration, retention, and successful completion Open
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View article: By Choice or by Force? Exploring the Nature of Informal Employment in Urban Mexico
By Choice or by Force? Exploring the Nature of Informal Employment in Urban Mexico Open
Using a special module of the 2015 Mexican Labour Force Survey with information on workers' preferences for jobs with social security coverage, I estimate that 80 per cent of informal workers in large urban areas would prefer to work in a …
View article: Taxes, Subsidies, and Gender Gaps in Hours and Wages
Taxes, Subsidies, and Gender Gaps in Hours and Wages Open
Using micro data from 17 countries in the Organisation for Economic Co-operation and Development, this paper documents a negative cross-country correlation between gender ratios in market hours and wages. We find that market hours by women…
View article: Medical Ethics and the Biopsychosocial Model for Patient Care: A Case Analysis for Improved Communication, Clinical Time, and Error Avoidance
Medical Ethics and the Biopsychosocial Model for Patient Care: A Case Analysis for Improved Communication, Clinical Time, and Error Avoidance Open
The practice of interdisciplinary medicine is one of the most effective and cooperative forms of medical management, which optimizes clinical care and outcomes for a patient. This model of care affords the patient the benefit of receiving …
View article: Inequality and Panel Income Changes: Conditions for Possibilities and Impossibilities
Inequality and Panel Income Changes: Conditions for Possibilities and Impossibilities Open
The question of who benefits from economic growth is usually assessed by using cross section data to calculate changes in income inequality. An alternative is to assess patterns of panel income changes. We derive theoretical conditions rec…
View article: A Dried Blood Spot Analysis for Solithromycin in Adolescents, Children, and Infants: A Short Communication
A Dried Blood Spot Analysis for Solithromycin in Adolescents, Children, and Infants: A Short Communication Open
Background: Solithromycin is a fourth-generation macrolide antibiotic with potential efficacy in pediatric community-acquired bacterial pneumonia. Pharmacokinetic (PK) studies of solithromycin in pediatric subjects are limited, therefore a…
View article: Entamoeba Histolytica: Updates in Clinical Manifestation, Pathogenesis, and Vaccine Development
Entamoeba Histolytica: Updates in Clinical Manifestation, Pathogenesis, and Vaccine Development Open
Entamoeba histolytica is the responsible parasite of amoebiasis and remains one of the top three parasitic causes of mortality worldwide. With increased travel and emigration to developed countries, infection is becoming more common in non…
View article: Population Pharmacokinetics and Safety of Solithromycin following Intravenous and Oral Administration in Infants, Children, and Adolescents
Population Pharmacokinetics and Safety of Solithromycin following Intravenous and Oral Administration in Infants, Children, and Adolescents Open
Solithromycin is a novel fluoroketolide antibiotic which was under investigation for the treatment of community-acquired bacterial pneumonia (CABP). A phase 1 study was performed to characterize the pharmacokinetics (PK) and safety of soli…