Robert S. Hoffman
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View article: Mismatched unrelated and haploidentical transplant with post-transplant cyclophosphamide-based graft versus host disease prophylaxis are effective for myelofibrosis
Mismatched unrelated and haploidentical transplant with post-transplant cyclophosphamide-based graft versus host disease prophylaxis are effective for myelofibrosis Open
Background Allogeneic hematopoietic cell transplant (HCT) remains the only curative option for myelofibrosis (MF); however, patients with MF historically have had poor survival outcomes due to high rates of graft failure and non-relapse mo…
View article: Bone marrow adipocytes (BMA) as a novel biomarker of molecular response in patients with essential thrombocythemia (ET) and polycythemia vera (PV) treated with pegylated interferon alfa-2A
Bone marrow adipocytes (BMA) as a novel biomarker of molecular response in patients with essential thrombocythemia (ET) and polycythemia vera (PV) treated with pegylated interferon alfa-2A Open
Background: The functional importance of bone marrow adipocytes (BMA) is frequently overlooked even though they are critical components of the BM (bone marrow) microenvironment. BMA have been proposed to play a supportive role within the h…
View article: Dexmedetomidine for Alcohol Withdrawal: Looks Can Be Deceiving
Dexmedetomidine for Alcohol Withdrawal: Looks Can Be Deceiving Open
Alcohol is a gamma-aminobutyric acid (GABA) receptor agonist and an N-methyl-D-aspartate (NMDA) receptor antagonist. Although benzodiazepines and barbiturates are the standard treatments for alcohol withdrawal, there is some recent interes…
View article: A novel synonymous SGCA variant associated with arrhythmogenic cardiomyopathy in limb-girdle muscular dystrophy type 3
A novel synonymous SGCA variant associated with arrhythmogenic cardiomyopathy in limb-girdle muscular dystrophy type 3 Open
Background Limb-girdle muscular dystrophy type 3 (LGMDR3) is an autosomal recessive disorder caused by pathogenic variants in the SGCA gene encoding α-sarcoglycan. While LGMDR3 predominantly presents with progressive proximal muscle weakne…
View article: Effectiveness and tolerability of methylthioninium chloride (methylene blue) for the treatment of methemoglobinemia: twenty-four years of experience at a single poison center
Effectiveness and tolerability of methylthioninium chloride (methylene blue) for the treatment of methemoglobinemia: twenty-four years of experience at a single poison center Open
In this series, methylthioninium chloride was both efficacious and well tolerated in patients with methemoglobinemia, with a single dose of 1-2 mg/kg being sufficient to treat most patients.
View article: Role of HMGA2 Overexpression Caused By Specific Genetic <i>HMGA2</i> Aberrations in Disease Progression in Calreticulin-Mutated Myelofibrosis Patients
Role of HMGA2 Overexpression Caused By Specific Genetic <i>HMGA2</i> Aberrations in Disease Progression in Calreticulin-Mutated Myelofibrosis Patients Open
High mobility group AT hook 1 and 2 (HMGA1 and HMGA2) have been implicated as drivers of disease progression in patients with JAK2V617F+ myeloproliferative neoplasms (MPNs) (Andrieux et al. Genes Chromosomes Cancer 2004, Li et al. Blood 20…
View article: Legislating the Final Frontier
Legislating the Final Frontier Open
The frontier of outer space has always been a compelling subject of interest, capturing the collective imagination of humanity for decades. Initially, the realm of space was not just a venue for scientific exploration and technological inn…
View article: Development and validation of quantitative PCR assays for HIV-associated cryptococcal meningitis in sub-Saharan Africa: a diagnostic accuracy study
Development and validation of quantitative PCR assays for HIV-associated cryptococcal meningitis in sub-Saharan Africa: a diagnostic accuracy study Open
European and Developing Countries Clinical Trials Partnership; Swedish International Development Cooperation Agency; Wellcome Trust/UK Medical Research Council/UKAID Joint Global Health Trials; and UK National Institute for Health Research.
View article: Successful Treatment of Confirmed Severe Bupropion Cardiotoxicity With Veno-Arterial Extracorporeal Membrane Oxygenation Initiation Prior to Cardiac Arrest
Successful Treatment of Confirmed Severe Bupropion Cardiotoxicity With Veno-Arterial Extracorporeal Membrane Oxygenation Initiation Prior to Cardiac Arrest Open
Bupropion is a substituted cathinone (β-keto amphetamine) norepinephrine/dopamine reuptake inhibitor andnoncompetitive nicotinic acetylcholine receptor antagonist that is frequently used to treat major depressive disorder. Bupropion overdo…
View article: Data from Correction of the Abnormal Trafficking of Primary Myelofibrosis CD34<sup>+</sup> Cells by Treatment with Chromatin-Modifying Agents
Data from Correction of the Abnormal Trafficking of Primary Myelofibrosis CD34<sup>+</sup> Cells by Treatment with Chromatin-Modifying Agents Open
The abnormal trafficking of CD34+ cells is a unique characteristic of primary myelofibrosis (PMF). We have further studied the behavior of PMF CD34+ cells by examining their homing to the marrow and the spleens of nonobese diabetic/severe …
View article: Extracorporeal Treatment for Methotrexate Poisoning: Systematic Review and Recommendations from the EXTRIP Workgroup.
Extracorporeal Treatment for Methotrexate Poisoning: Systematic Review and Recommendations from the EXTRIP Workgroup. Open
Methotrexate is used in the treatment of many malignancies, rheumatological diseases, and inflammatory bowel disease. Toxicity from use is associated with severe morbidity and mortality. Rescue treatments include intravenous hydration, fol…
View article: Extracorporeal Treatment for Methotrexate Poisoning
Extracorporeal Treatment for Methotrexate Poisoning Open
Methotrexate is used in the treatment of many malignancies, rheumatological diseases, and inflammatory bowel disease. Toxicity from use is associated with severe morbidity and mortality. Rescue treatments include intravenous hydration, fol…
View article: Meeting people where they are: implementing hospital-based substance use harm reduction
Meeting people where they are: implementing hospital-based substance use harm reduction Open
Background Hospital-based addiction care focuses on assessing and diagnosing substance use disorders, managing withdrawal, and initiating medications for addiction treatment. Hospital harm reduction is generally limited to prescribing nalo…
View article: Extracorporeal Treatment for Gabapentin and Pregabalin Poisoning: Systematic Review and Recommendations From the EXTRIP Workgroup
Extracorporeal Treatment for Gabapentin and Pregabalin Poisoning: Systematic Review and Recommendations From the EXTRIP Workgroup Open
Toxicity from gabapentin and pregabalin overdose is commonly encountered. Treatment is supportive, and the use of extracorporeal treatments (ECTRs) is controversial. The EXTRIP workgroup conducted systematic reviews of the literature and s…
View article: Recommendations for the Empirical Assessment of Human-AI Work Systems: A Contribution to AI Measurement Science
Recommendations for the Empirical Assessment of Human-AI Work Systems: A Contribution to AI Measurement Science Open
This Report is a companion to the Report titled "Requirements for the Evaluation of Human-AI Work Systems." Whereas that Report focused on the minimum necessary empirical requirements for the assessment of AI systems, this Report provides …
View article: The Plausibility Gap: A model of sensemaking
The Plausibility Gap: A model of sensemaking Open
When people make plausibility judgments about an assertion, an event, or a piece of evidence, they are gauging whether it makes sense. Therefore, we can treat plausibility judgments as sensemaking activities. In this paper, we review the r…
View article: Systematic review on the use of activated charcoal for gastrointestinal decontamination following acute oral overdose
Systematic review on the use of activated charcoal for gastrointestinal decontamination following acute oral overdose Open
The use of activated charcoal in poisoning remains both a pillar of modern toxicology and a source of debate. Following the publication of the joint position statements on the use of single-dose and multiple-dose activated charcoal by the …