Robert S. Hoffman
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View article: Bone marrow adipocytes (BMA) as a novel biomarker of molecular response in patients with essential thrombocythemia (ET) and polycythemia vera (PV) treated with pegylated interferon alfa-2A
Bone marrow adipocytes (BMA) as a novel biomarker of molecular response in patients with essential thrombocythemia (ET) and polycythemia vera (PV) treated with pegylated interferon alfa-2A Open
Background: The functional importance of bone marrow adipocytes (BMA) is frequently overlooked even though they are critical components of the BM (bone marrow) microenvironment. BMA have been proposed to play a supportive role within the h…
View article: Dexmedetomidine for Alcohol Withdrawal: Looks Can Be Deceiving
Dexmedetomidine for Alcohol Withdrawal: Looks Can Be Deceiving Open
Alcohol is a gamma-aminobutyric acid (GABA) receptor agonist and an N-methyl-D-aspartate (NMDA) receptor antagonist. Although benzodiazepines and barbiturates are the standard treatments for alcohol withdrawal, there is some recent interes…
View article: A novel synonymous SGCA variant associated with arrhythmogenic cardiomyopathy in limb-girdle muscular dystrophy type 3
A novel synonymous SGCA variant associated with arrhythmogenic cardiomyopathy in limb-girdle muscular dystrophy type 3 Open
Background Limb-girdle muscular dystrophy type 3 (LGMDR3) is an autosomal recessive disorder caused by pathogenic variants in the SGCA gene encoding α-sarcoglycan. While LGMDR3 predominantly presents with progressive proximal muscle weakne…
View article: Effectiveness and tolerability of methylthioninium chloride (methylene blue) for the treatment of methemoglobinemia: twenty-four years of experience at a single poison center
Effectiveness and tolerability of methylthioninium chloride (methylene blue) for the treatment of methemoglobinemia: twenty-four years of experience at a single poison center Open
In this series, methylthioninium chloride was both efficacious and well tolerated in patients with methemoglobinemia, with a single dose of 1-2 mg/kg being sufficient to treat most patients.
View article: Role of HMGA2 Overexpression Caused By Specific Genetic <i>HMGA2</i> Aberrations in Disease Progression in Calreticulin-Mutated Myelofibrosis Patients
Role of HMGA2 Overexpression Caused By Specific Genetic <i>HMGA2</i> Aberrations in Disease Progression in Calreticulin-Mutated Myelofibrosis Patients Open
High mobility group AT hook 1 and 2 (HMGA1 and HMGA2) have been implicated as drivers of disease progression in patients with JAK2V617F+ myeloproliferative neoplasms (MPNs) (Andrieux et al. Genes Chromosomes Cancer 2004, Li et al. Blood 20…
View article: Legislating the Final Frontier
Legislating the Final Frontier Open
The frontier of outer space has always been a compelling subject of interest, capturing the collective imagination of humanity for decades. Initially, the realm of space was not just a venue for scientific exploration and technological inn…
View article: Data from Correction of the Abnormal Trafficking of Primary Myelofibrosis CD34<sup>+</sup> Cells by Treatment with Chromatin-Modifying Agents
Data from Correction of the Abnormal Trafficking of Primary Myelofibrosis CD34<sup>+</sup> Cells by Treatment with Chromatin-Modifying Agents Open
The abnormal trafficking of CD34+ cells is a unique characteristic of primary myelofibrosis (PMF). We have further studied the behavior of PMF CD34+ cells by examining their homing to the marrow and the spleens of nonobese diabetic/severe …
View article: Extracorporeal Treatment for Methotrexate Poisoning: Systematic Review and Recommendations from the EXTRIP Workgroup.
Extracorporeal Treatment for Methotrexate Poisoning: Systematic Review and Recommendations from the EXTRIP Workgroup. Open
Methotrexate is used in the treatment of many malignancies, rheumatological diseases, and inflammatory bowel disease. Toxicity from use is associated with severe morbidity and mortality. Rescue treatments include intravenous hydration, fol…
View article: Extracorporeal Treatment for Methotrexate Poisoning
Extracorporeal Treatment for Methotrexate Poisoning Open
Methotrexate is used in the treatment of many malignancies, rheumatological diseases, and inflammatory bowel disease. Toxicity from use is associated with severe morbidity and mortality. Rescue treatments include intravenous hydration, fol…
View article: Recommendations for the Empirical Assessment of Human-AI Work Systems: A Contribution to AI Measurement Science
Recommendations for the Empirical Assessment of Human-AI Work Systems: A Contribution to AI Measurement Science Open
This Report is a companion to the Report titled "Requirements for the Evaluation of Human-AI Work Systems." Whereas that Report focused on the minimum necessary empirical requirements for the assessment of AI systems, this Report provides …
View article: The Plausibility Gap: A model of sensemaking
The Plausibility Gap: A model of sensemaking Open
When people make plausibility judgments about an assertion, an event, or a piece of evidence, they are gauging whether it makes sense. Therefore, we can treat plausibility judgments as sensemaking activities. In this paper, we review the r…
View article: Systematic review on the use of activated charcoal for gastrointestinal decontamination following acute oral overdose
Systematic review on the use of activated charcoal for gastrointestinal decontamination following acute oral overdose Open
The use of activated charcoal in poisoning remains both a pillar of modern toxicology and a source of debate. Following the publication of the joint position statements on the use of single-dose and multiple-dose activated charcoal by the …
View article: A Report of Two Cases: Unlearning Lactic Acidosis
A Report of Two Cases: Unlearning Lactic Acidosis Open
Introduction: The term “lactic acidosis” reinforces the misconception that lactate contributes to acidemia. Although it is common to discover an anion gap acidosis with a concomitant elevated lactate concentration, the two are not mutually…