Robert Hofmann
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View article: Early detection of climate change-induced shallow landslides with IoT-technology
Early detection of climate change-induced shallow landslides with IoT-technology Open
Climate change in the Alps is increasing winter rainfall and raising the snowline, thereby elevating the risk of shallow landslides and threatening infrastructure. However, forecasting such events remains challenging due to their localized…
View article: Life and death in Trypillia times: Interdisciplinary analyses of the unique human remains from the settlement of Kosenivka, Ukraine (3700–3600 BCE)
Life and death in Trypillia times: Interdisciplinary analyses of the unique human remains from the settlement of Kosenivka, Ukraine (3700–3600 BCE) Open
We present an interdisciplinary analysis of finds from the Trypillia settlement of Kosenivka, Ukraine (ca. 3700–3600 BCE, Trypillia C1–2), that links information on human, faunal, and botanical remains with archaeological data to provide e…
View article: Impacts on Embankments, Rigid and Flexible Barriers Against Rockslides: Model Experiments vs. DEM Simulations
Impacts on Embankments, Rigid and Flexible Barriers Against Rockslides: Model Experiments vs. DEM Simulations Open
As a result of climate change, rockfalls and rock avalanches as well as landslides lead to an increasing hazard for settlement areas and infrastructures. The hazards of such mass movements mean that numerous protective structures must be p…
View article: Outcomes With Belatacept Exposure During Pregnancy in Kidney Transplant Recipients: A Case Series
Outcomes With Belatacept Exposure During Pregnancy in Kidney Transplant Recipients: A Case Series Open
Background. Posttransplant fertility returns quickly, and female recipients of child-bearing age may conceive while on immunosuppression. However, pregnancy after transplantation confers risks to the recipient, transplant, and fetus, inclu…
View article: Impacts on Protective Structures against Gravitational Mass Movements—Scaling from Model Tests to Real Events
Impacts on Protective Structures against Gravitational Mass Movements—Scaling from Model Tests to Real Events Open
Gravitational mass movements such as rockfalls, landslides, rock avalanches, or debris flows are increasingly endangering settlement areas and infrastructure facilities in the Alpine region as a result of climate change. An essential compo…
View article: Community negotiation and pasture partitioning at the Trypillia settlement of Maidanetske
Community negotiation and pasture partitioning at the Trypillia settlement of Maidanetske Open
The inhabitants of the vast Chalcolithic Trypillia sites of Eastern Europe required highly organised strategies to meet subsistence needs. Here, the authors use isotopic analyses of faunal remains from Maidanetske, Ukraine, to identify int…
View article: Impacts of Gravitational Mass Movements on Protective Structures—Rock Avalanches/Granular Flow
Impacts of Gravitational Mass Movements on Protective Structures—Rock Avalanches/Granular Flow Open
Rock avalanches and landslides lead to gravitational flow into their runout areas, which poses increasing danger to settlement areas and infrastructure in the Alpine region as a result of climate change. In recent years, a significant incr…
View article: Challenges and Opportunities in IBD Clinical Trial Design
Challenges and Opportunities in IBD Clinical Trial Design Open
peer reviewed
View article: Climate driven Holocene erosion in central Ukraine
Climate driven Holocene erosion in central Ukraine Open
The younger Quaternary erosion history was reconstructed in a catchment close to the Chalcolithic giant settlement Maidanetske, central Ukraine based on dated sediment sequences. Four trenches and a long percussion drill-core were analyzed…
View article: P465 UC trial designed more than 5 years ago in the light of the EMA guideline on the development of new medicinal products for the treatment of ulcerative colitis
P465 UC trial designed more than 5 years ago in the light of the EMA guideline on the development of new medicinal products for the treatment of ulcerative colitis Open
Developing a new drug in ulcerative colitis (UC) is challenging. More challenging is the clinical trial design. We highlight, here, the Phase 3 trial design of a new 5ASA drug (TP0503) and compare it to the current EMA ‘guideline on the de…
View article: P707 38 Weeks treatment of UC patients with different daily doses of mesalazine
P707 38 Weeks treatment of UC patients with different daily doses of mesalazine Open
In everyday practice, the management of UC patients is not limited to a 6 week induction period. Patients in clinical remission will continue treatment to maintain remission and avoid recurrence. For non-remitters or for patients with clin…
View article: P608 Crohn’s disease patients with high baseline symptoms achieve clinical remission more rapidly with Budesonide than with Mesalazine
P608 Crohn’s disease patients with high baseline symptoms achieve clinical remission more rapidly with Budesonide than with Mesalazine Open
Budesonide (Entocort®) showed non-inferiority compared with Mesalazine (Pentasa®) in Japanese patients with mild-to-moderate active Crohn’s disease (CD) after 8 weeks of treatment.1 The aim of this analysis was to compare 2, 4, and 8 weeks…
View article: P678 Treatment of moderate to severe UC patients with new 5ASA tablets
P678 Treatment of moderate to severe UC patients with new 5ASA tablets Open
In previous mesalazine trials, patients with mild-to-moderate UC disease were investigated. Mesalazine is not thought to be efficacious for severe patients. For the first time, we present the efficacy results of mesalazine in moderate to s…
View article: P402 Systemic steroids vs. local acting steroids: Relative risk for corticosteroid-related adverse events
P402 Systemic steroids vs. local acting steroids: Relative risk for corticosteroid-related adverse events Open
The efficacy of systemic corticosteroid to treat active inflammatory bowel diseases is well known. However, these corticosteroids, due to their systemic availability are associated with potentially serious side effects. Budesonide offers a…
View article: PWE-004 Tapering with budesonide – label recommendation versus clinical reality
PWE-004 Tapering with budesonide – label recommendation versus clinical reality Open
Introduction Symptoms of steroid withdrawal may be avoided in most patients by tapering the dose over time when deciding to discontinue treatment. Patients exposed to steroid therapy, even if only for a short period of time are very likely…
View article: Belatacept during pregnancy in renal transplant recipients: Two case reports
Belatacept during pregnancy in renal transplant recipients: Two case reports Open
Impaired fertility is common among patients with chronic organ failure, including end-stage renal disease (ESRD). Women of childbearing age undergoing transplantation may experience rapid return of fertility. Pregnancy posttransplant prese…
View article: P-042 Prescribing Customs of Mesalamine in Various European Countries
P-042 Prescribing Customs of Mesalamine in Various European Countries Open
The existing ECCO guideline is vague as far as the actual dose recommendation is concerned: “Extensive ulcerative colitis of mild–moderate severity should initially be treated with oral 5-ASA >2 g/d.” The ACG guideline recommends “…doses o…
View article: P-102 The Regulatory and Legal Complexity of the Multicentre, Multinational Clinical Trial with TP05
P-102 The Regulatory and Legal Complexity of the Multicentre, Multinational Clinical Trial with TP05 Open
The evidence provided by multinational clinical trials is of outstanding importance for new drugs, new medical devices and new procedures. Large multinational randomised clinical trials are under a financial and organizational threat becau…
View article: Comparison of Two Forms of Loperamide–Simeticone and a Probiotic Yeast (Saccharomyces boulardii) in the Treatment of Acute Diarrhoea in Adults: A Randomised Non-Inferiority Clinical Trial
Comparison of Two Forms of Loperamide–Simeticone and a Probiotic Yeast (Saccharomyces boulardii) in the Treatment of Acute Diarrhoea in Adults: A Randomised Non-Inferiority Clinical Trial Open
ClinicalTrials.gov identifier NCT00807326.