Robert Hooghe
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View article: Suppressor of Cytokine Signaling 7 Inhibits Prolactin, Growth Hormone, and Leptin Signaling by Interacting with STAT5 or STAT3 and Attenuating Their Nuclear Translocation
Suppressor of Cytokine Signaling 7 Inhibits Prolactin, Growth Hormone, and Leptin Signaling by Interacting with STAT5 or STAT3 and Attenuating Their Nuclear Translocation Open
We report here the role of one of the less studied members of the family of suppressors of cytokine signaling (SOCS), namely SOCS-7, in cytokine signaling. We demonstrate that SOCS-7 inhibits prolactin (PRL), growth hormone (GH), or leptin…
View article: Clinical and biological characterization of macroprolactinemia with and without prolactin-IgG complexes
Clinical and biological characterization of macroprolactinemia with and without prolactin-IgG complexes Open
OBJECTIVE: Macroprolactinemia, which can be detected by a polyethylene glycol (PEG) precipitation test, is a clinically and biologically heterogeneous condition. In this study, we analyzed whether the clinical presentation, the hormonal fi…
View article: Expression of IL-6 mRNA in normal rat and human pituitaries and in human pituitary adenomas.
Expression of IL-6 mRNA in normal rat and human pituitaries and in human pituitary adenomas. Open
Cells expressing IL-6 mRNA were detected by in situ hybridization in normal pituitaries. In normal untreated rat pituitary the expression was very low. Within hours after IP administration of liposaccharide, IL-6 mRNA accumulated in the an…
View article: Further Characterization of Rat 26,000 Prolactin as a Glycoprotein with Essentially O‐Linked Carbohydrate Chains
Further Characterization of Rat 26,000 Prolactin as a Glycoprotein with Essentially O‐Linked Carbohydrate Chains Open
In the rat two major molecular variants of prolactin are recorded i.e. 23,000 M r and glycosylated 26,000 M r . In order to further characterize the glycosylated 26,000 rat prolactin molecular variant, rat pituitary cell lysates were diges…
View article: Properties of vasoactive‐intestinal‐peptide receptors and β‐adrenoceptors in the murine radiation leukemia‐virus‐induced lymphoma cell line BL/VL<sub>3</sub>
Properties of vasoactive‐intestinal‐peptide receptors and β‐adrenoceptors in the murine radiation leukemia‐virus‐induced lymphoma cell line BL/VL<sub>3</sub> Open
Based on radioligand binding and adenylate cyclase activation, functional receptors to vasoactive intestinal peptide(VIP)/helodermin, were shown to coexist with β 2 ‐adrenoceptors and prostaglandin receptors in membranes from a cultured cl…
View article: Prolactin Cell Subpopulations Separated on Discontinuous Percoll Gradient: An Immunocytochemical, Biochemical, and Physiological Characterization*
Prolactin Cell Subpopulations Separated on Discontinuous Percoll Gradient: An Immunocytochemical, Biochemical, and Physiological Characterization* Open
A single-step procedure was devised to separate PRL cells from the rat anterior pituitary gland. After dissociation, cells were centrifuged on a Percoll gradient. Three layers were recovered. The composition of the different layers was eva…
View article: Cellular basis of regulation of expression of idiotype. II. Immunity to anti-MOPC-460 idiotype antibodies increases the level of anti-trinitrophenyl antibodies bearing 460 idiotypes.
Cellular basis of regulation of expression of idiotype. II. Immunity to anti-MOPC-460 idiotype antibodies increases the level of anti-trinitrophenyl antibodies bearing 460 idiotypes. Open
The antibody response of BALB/c mice to trinitrophenyl (TNP)-levan or TNP-Nocardia water-soluble mitogen (NWSM) includes a small but significant fraction of antibodies which share idiotypes (Id) with the dinitrophenyl (DNP)- and TNP-bindin…
View article: Role of antigenic structure in cell to cell cooperation.
Role of antigenic structure in cell to cell cooperation. Open
Two synthetic polypeptides which differ only in the order of amino acids in their NH2-terminal side chains, namely, (Tyr-Tyr-Glu-Glu)-poly(DLAla)- -poly(LLys) and (Tyr-Glu-Try-Glu)-poly(DLAla)- -poly(LLys), were found to be under different…
View article: Hairy cell leukemia: functional, immunologic, kinetic, and ultrastructural characterization
Hairy cell leukemia: functional, immunologic, kinetic, and ultrastructural characterization Open
A diagnosis of hairy cell leukemia was made by optic microscopy, phase- contrast microscopy, electron microscopy, scanning microscopy, and histochemistry of the abnormal blood cells. In vivo these cells were found to have a half-time in th…