Robert Huckstepp
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View article: International Consortium to Classify Ageing-related Pathologies (ICCARP) senescence definitions: achieving international consensus
International Consortium to Classify Ageing-related Pathologies (ICCARP) senescence definitions: achieving international consensus Open
With the global increase in ageing populations, a clear understanding of the physiological and pathological changes associated with ageing is vital for advancing research and clinical practice. Following the World Health Organization’s dec…
View article: Imaging Single-Cell Ca<sup>2+</sup> Dynamics of Brainstem Neurons and Glia in Freely Behaving Mice
Imaging Single-Cell Ca<sup>2+</sup> Dynamics of Brainstem Neurons and Glia in Freely Behaving Mice Open
In vivo brain imaging, using a combination of genetically encoded Ca2+ indicators and gradient refractive index (GRIN) lens, is a transformative technology that has become an increasingly potent research tool over the last decade. It allow…
View article: Innate Sleep Apnea in Spontaneously Hypertensive Rats Is Associated With Microvascular Rarefaction and Neuronal Loss in the preBötzinger Complex
Innate Sleep Apnea in Spontaneously Hypertensive Rats Is Associated With Microvascular Rarefaction and Neuronal Loss in the preBötzinger Complex Open
BACKGROUND: Sleep apnea (SA) is a major threat to physical health and carries a significant economic burden. These impacts are worsened by its interaction with, and induction of, its comorbidities. SA holds a bidirectional relationship wit…
View article: Innate sleep apnoea in spontaneously hypertensive rats is associated with microvascular rarefaction and neuronal loss in the preBötzinger Complex
Innate sleep apnoea in spontaneously hypertensive rats is associated with microvascular rarefaction and neuronal loss in the preBötzinger Complex Open
Sleep apnoea is a major threat to physical health and carries a significant economic burden. These impacts are worsened by its interaction with, and induction of, its comorbidities. Sleep apnoea holds a bidirectional relationship with hype…
View article: Analyzing the brainstem circuits for respiratory chemosensitivity in freely moving mice
Analyzing the brainstem circuits for respiratory chemosensitivity in freely moving mice Open
Regulation of systemic PCO 2 is a life-preserving homeostatic mechanism. In the medulla oblongata, the retrotrapezoid nucleus (RTN) and rostral medullary Raphe are proposed as CO 2 chemosensory nuclei mediating adaptive respiratory changes…
View article: Selective activation of Gαob by an adenosine A1 receptor agonist elicits analgesia without cardiorespiratory depression
Selective activation of Gαob by an adenosine A1 receptor agonist elicits analgesia without cardiorespiratory depression Open
The development of therapeutic agonists for G protein-coupled receptors (GPCRs) is hampered by the propensity of GPCRs to couple to multiple intracellular signalling pathways. This promiscuous coupling leads to numerous downstream cellular…
View article: An Improved Model of Moderate Sleep Apnoea for Investigating Its Effect as a Comorbidity on Neurodegenerative Disease
An Improved Model of Moderate Sleep Apnoea for Investigating Its Effect as a Comorbidity on Neurodegenerative Disease Open
Sleep apnoea is a highly prevalent disease that often goes undetected and is associated with poor clinical prognosis, especially as it exacerbates many different disease states. However, most animal models of sleep apnoea (e.g., intermitte…
View article: Author response: Analyzing the brainstem circuits for respiratory chemosensitivity in freely moving mice
Author response: Analyzing the brainstem circuits for respiratory chemosensitivity in freely moving mice Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Regulation of systemic…
View article: Identifying the recurrence of sleep apnea using a harmonic hidden Markov model
Identifying the recurrence of sleep apnea using a harmonic hidden Markov model Open
We propose to model time-varying periodic and oscillatory processes by means of a hidden Markov model where the states are defined through the spectral properties of a periodic regime. The number of states is unknown along with the relevan…
View article: A new physiologically realistic and clinically relevant model of sleep apnoea for investigating it’s effect as a comorbidity on neurodegenerative disease
A new physiologically realistic and clinically relevant model of sleep apnoea for investigating it’s effect as a comorbidity on neurodegenerative disease Open
Sleep apnoea is a highly prevalent disease but often goes undetected and is associated with poor clinical prognoses when combined with many different disease states. However, most animal models of sleep apnoea (e.g., intermittent hypoxia) …
View article: Bayesian Model Search for Nonstationary Periodic Time Series
Bayesian Model Search for Nonstationary Periodic Time Series Open
We propose a novel Bayesian methodology for analyzing nonstationary time series that exhibit oscillatory behavior. We approximate the time series using a piecewise oscillatory model with unknown periodicities, where our goal is to estimate…
View article: Connexin26 mediates CO2-dependent regulation of breathing via glial cells of the medulla oblongata
Connexin26 mediates CO2-dependent regulation of breathing via glial cells of the medulla oblongata Open
Breathing is highly sensitive to the PCO 2 of arterial blood. Although CO 2 is detected via the proxy of pH, CO 2 acting directly via Cx26 may also contribute to the regulation of breathing. Here we exploit our knowledge of the structural …
View article: Elastomeric polyamide biomaterials with stereochemically tuneable mechanical properties and shape memory
Elastomeric polyamide biomaterials with stereochemically tuneable mechanical properties and shape memory Open
Biocompatible polymers are widely used in tissue engineering and biomedical device applications. However, few biomaterials are suitable for use as long-term implants and these examples usually possess limited property scope, can be difficu…
View article: Connexin26 mediates CO<sub>2</sub>-dependent regulation of breathing via glial cells of the medulla oblongata
Connexin26 mediates CO<sub>2</sub>-dependent regulation of breathing via glial cells of the medulla oblongata Open
Breathing is highly sensitive to the PCO 2 of arterial blood. Although CO 2 is detected via the proxy of pH, CO 2 acting directly via Cx26 may also contribute to the regulation of breathing. Here we exploit our knowledge of the structural …
View article: Selective activation of Gαob by an adenosine A1 receptor agonist elicits analgesia without cardiorespiratory depression
Selective activation of Gαob by an adenosine A1 receptor agonist elicits analgesia without cardiorespiratory depression Open
Summary The development of therapeutic agonists for G protein-coupled receptors (GPCRs) is hampered by the propensity of GPCRs to couple to multiple intracellular signalling pathways. This promiscuous coupling leads to numerous downstream …
View article: Identifying the Recurrence of Sleep Apnea Using a Harmonic Hidden Markov\n Model
Identifying the Recurrence of Sleep Apnea Using a Harmonic Hidden Markov\n Model Open
We propose to model time-varying periodic and oscillatory processes by means\nof a hidden Markov model where the states are defined through the spectral\nproperties of a periodic regime. The number of states is unknown along with the\nrele…
View article: Identifying the Recurrence of Sleep Apnea Using a Spectral Hidden Markov Model
Identifying the Recurrence of Sleep Apnea Using a Spectral Hidden Markov Model Open
We propose to model time-varying periodic and oscillatory processes by means of a hidden Markov model where the states are defined through the spectral properties of a periodic regime. The number of states is unknown along with the relevan…
View article: Bayesian Model Search for Nonstationary Periodic Time Series
Bayesian Model Search for Nonstationary Periodic Time Series Open
We propose a novel Bayesian methodology for analyzing nonstationary time series that exhibit oscillatory behavior. We approximate the time series using a piecewise oscillatory model with unknown periodicities, where our goal is to estimate…
View article: Your input is a breath of fresh air! A chemosensory microcircuit of medullary raphe and RTN neurons
Your input is a breath of fresh air! A chemosensory microcircuit of medullary raphe and RTN neurons Open
Breathing is our first act upon birth and the last action we complete before death. The first to last breath taken, is in fact, how we define someone’s life. Since it was first reported that the blood concentration of CO2istightly controll…
View article: Bayesian Model Search for Nonstationary Periodic Time Series
Bayesian Model Search for Nonstationary Periodic Time Series Open
We propose a novel Bayesian methodology for analyzing nonstationary time series that exhibit oscillatory behavior. We approximate the time series using a piecewise oscillatory model with unknown periodicities, where our goal is to estimate…
View article: Bayesian Model Search for Nonstationary Periodic Time Series
Bayesian Model Search for Nonstationary Periodic Time Series Open
We propose a novel Bayesian methodology for analyzing nonstationary time series that exhibit oscillatory behaviour. We approximate the time series using a piecewise oscillatory model with unknown periodicities, where our goal is to estimat…
View article: Analyzing the neuroglial brainstem circuits for respiratory chemosensitivity in freely moving mice
Analyzing the neuroglial brainstem circuits for respiratory chemosensitivity in freely moving mice Open
The regulated excretion of CO 2 during breathing is a key life-preserving homeostatic mechanism. In the rostral medulla oblongata, neurons in two nuclei -the retrotrapezoid nucleus (RTN) and the rostral medullary Raphe -have been proposed …
View article: Distinct parafacial regions in control of breathing in adult rats
Distinct parafacial regions in control of breathing in adult rats Open
Recently, based on functional differences, we subdivided neurons juxtaposed to the facial nucleus into two distinct populations, the parafacial ventral and lateral regions, i.e., pFV and pFL. Little is known about the composition of these …