Robert Hurwitz
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View article: Infection-induced elevation of gut glycosaminoglycans fosters microbiota expansion in Drosophila melanogaster
Infection-induced elevation of gut glycosaminoglycans fosters microbiota expansion in Drosophila melanogaster Open
While host genetics influence the composition of intestinal microbial communities, host genetic factors controlling the abundance of intestinal commensals remain to be determined. We perform a genome-wide association study in Drosophila me…
View article: Infection-Induced Elevation of Gut Glycosaminoglycans Fosters Microbiota Expansion in <i>Drosophila melanogaster</i>
Infection-Induced Elevation of Gut Glycosaminoglycans Fosters Microbiota Expansion in <i>Drosophila melanogaster</i> Open
Summary While host genetics influence the composition of intestinal microbial communities, host genetic factors controlling the abundance of intestinal commensals remain to be determined. Here, we performed a genome-wide association (GWA) …
View article: PEGylated Recombinant <i>Aplysia punctata</i> Ink Toxin Depletes Arginine and Lysine and Inhibits the Growth of Tumor Xenografts
PEGylated Recombinant <i>Aplysia punctata</i> Ink Toxin Depletes Arginine and Lysine and Inhibits the Growth of Tumor Xenografts Open
In recent years, a novel treatment method for cancer has emerged, which is based on the starvation of tumors of amino acids like arginine. The deprivation of arginine in serum is based on enzymatic degradation and can be realized by argini…
View article: Tyrosine halogenation converts α-defensins into potent immunomodulators
Tyrosine halogenation converts α-defensins into potent immunomodulators Open
Neutrophils are immune cells that eliminate microbes using a powerful arsenal of reactive oxygen species, hypohalous acids, proteases, and antimicrobial peptides — yet how these cytotoxic effectors act in concert remains poorly understood.…
View article: Resistance to host antimicrobial peptides mediates resilience of gut commensals during infection and aging in <i>Drosophila</i>
Resistance to host antimicrobial peptides mediates resilience of gut commensals during infection and aging in <i>Drosophila</i> Open
Resilience to short-term perturbations, like inflammation, is a fundamental feature of microbiota, yet the underlying mechanisms of microbiota resilience are incompletely understood. Here, we show that Lactiplantibacillus plantarum , a maj…
View article: Human GBP1 Is Involved in the Repair of Damaged Phagosomes/Endolysosomes
Human GBP1 Is Involved in the Repair of Damaged Phagosomes/Endolysosomes Open
Mouse guanylate-binding proteins (mGBPs) are recruited to various invasive pathogens, thereby conferring cell-autonomous immunity against these pathogens. However, whether and how human GBPs (hGBPs) target M. tuberculosis (Mtb) and L. mono…
View article: Resistance to host antimicrobial peptides mediates resilience of gut commensals during infection and aging in<i>Drosophila</i>
Resistance to host antimicrobial peptides mediates resilience of gut commensals during infection and aging in<i>Drosophila</i> Open
Resilience to short-term perturbations, like inflammation, is a fundamental feature of microbiota, yet the underlying mechanisms of microbiota resilience are incompletely understood. Here we show that Lactiplantibacillus plantarum , a majo…
View article: PEGylated recombinant<i>Aplysia punctata</i>ink toxin depletes arginine and lysine and inhibits growth of tumor xenografts
PEGylated recombinant<i>Aplysia punctata</i>ink toxin depletes arginine and lysine and inhibits growth of tumor xenografts Open
In recent years, a novel treatment method for cancer emerged, which is based on the starvation of tumors of amino acids like arginine. The deprivation of arginine in serum is based on enzymatic degradation and can be realized by arginine d…
View article: Flagellin lysine methyltransferase FliB catalyzes a [4Fe-4S] mediated methyl transfer reaction
Flagellin lysine methyltransferase FliB catalyzes a [4Fe-4S] mediated methyl transfer reaction Open
The methyltransferase FliB posttranslationally modifies surface-exposed ɛ-N-lysine residues of flagellin, the protomer of the flagellar filament in Salmonella enterica (S . enterica) . Flagellin methylation, reported originally in 1959, wa…
View article: Intercellular coupling between peripheral circadian oscillators by TGF-β signaling
Intercellular coupling between peripheral circadian oscillators by TGF-β signaling Open
Paracrine TGF-β signaling is crucial to maintain robust and coherent circadian rhythms of peripheral oscillator networks.
View article: Flagellin lysine methyltransferase FliB catalyzes a [4Fe-4S] mediated methyl transfer reaction
Flagellin lysine methyltransferase FliB catalyzes a [4Fe-4S] mediated methyl transfer reaction Open
The methyltransferase FliB posttranslationally modifies surface-exposed ɛ-N-lysine residues of flagellin, the protomer of the flagellar filament in Salmonella enterica (S. enterica). Flagellin methylation, reported originally in 1959, was …
View article: Molecular analysis of the acid sphingomyelinase deficiency in a family with an intermediate form of Niemann-Pick disease.
Molecular analysis of the acid sphingomyelinase deficiency in a family with an intermediate form of Niemann-Pick disease. Open
A novel point mutation in the lysosomal acid sphingomyelinase gene has been identified in the recently reported Serbian family with a clinically and biochemically atypical intermediate form of Niemann-Pick disease. The mutation was a T1171…
View article: Author Correction: The Henna pigment Lawsone activates the Aryl Hydrocarbon Receptor and impacts skin homeostasis
Author Correction: The Henna pigment Lawsone activates the Aryl Hydrocarbon Receptor and impacts skin homeostasis Open
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
View article: ADP heptose, a novel pathogen‐associated molecular pattern identified in <i>Helicobacter pylori</i>
ADP heptose, a novel pathogen‐associated molecular pattern identified in <i>Helicobacter pylori</i> Open
The gastric pathogen Helicobacter pylori activates the NF‐κB pathway in human epithelial cells via the recently discovered α‐kinase 1 TRAF‐interacting protein with forkhead‐associated domain (TIFA) axis. We and others showed that this path…
View article: The Aryl Hydrocarbon Receptor senses the Henna pigment Lawsone and mediates Yin-Yang effects on skin homeostasis
The Aryl Hydrocarbon Receptor senses the Henna pigment Lawsone and mediates Yin-Yang effects on skin homeostasis Open
As a first host barrier, the skin is constantly exposed to environmental insults that perturb its integrity. Tight regulation of skin homeostasis is largely controlled by the aryl hydrocarbon receptor (AhR). Here, we demonstrate that Henna…
View article: A Case of a Giant Ovarian Mass in a Teenager: Case Report and Review of Literature
A Case of a Giant Ovarian Mass in a Teenager: Case Report and Review of Literature Open
Ovarian tumors in children are uncommon, whether benign or malignant. The diagnosis must be considered, however, when there is unexplained pelvic pain. A palpable mass further raises suspicion and warrants prompt pelvic ultrasound. On occa…
View article: Chlamydia trachomatis Prevents Apoptosis Via Activation of PDPK1-MYC and Enhanced Mitochondrial Binding of Hexokinase II
Chlamydia trachomatis Prevents Apoptosis Via Activation of PDPK1-MYC and Enhanced Mitochondrial Binding of Hexokinase II Open
The intracellular human bacterial pathogen Chlamydia trachomatis pursues effective strategies to protect infected cells against death-inducing stimuli. Here, we show that Chlamydia trachomatis infection evokes 3-phosphoinositide-dependent …