Explanipedia

The first Australian evidence‐based guidelines on male infertility Open

Darren Katz, Liza O’Donnell, Robert I. McLachlan, Timothy J. M. Moss, Clare Boothroyd , et al. · 2025

Introduction Infertility affects about one in six couples and a male factor may contribute to 50% of cases. Until recently, no Australian‐based clinical guidelines for the management of male infertility had been published. A panel of exper…

SAT-181 Audit of spermatogenesis induction in men with hypogonadotropic hypogonadism in clinical andrology practice Open

Yeung‐Ae Park, Stella Sarlos, Robert I. McLachlan, Ie-Wen Sim, Rita Upreti , et al. · 2025

Disclosure: Y. Park: None. S. Sarlos: None. R.I. McLachlan: None. I. Sim: None. R. Upreti: None. C.A. Allan: None. Introduction: Infertility affects one-third of couples, with male factors contributing up to 50%. Spermatogenesis induction …

Soluble CD52 mediates immune suppression by human seminal fluid Open

Leonard C. Harrison, Natalie L. Stone, Esther Bandala‐Sanchez, Nicholas D. Huntington, Robert I. McLachlan , et al. · 2024

Seminal fluid provides for the carriage and nutrition of sperm, but also modulates immunity to prevent allo-rejection of sperm by the female. Immune suppression by seminal fluid has been associated with extracellular vesicles, originally t…

7119 Klinefelter Syndrome in a Tertiary Referral Clinic: A Case Series and Clinical Audit Open

Jinghang Luo, Stella Sarlos, Rinky Giri, Ie‐Wen Sim, Robert I. McLachlan , et al. · 2024

Disclosure: J. Luo: None. S. Sarlos: None. R. Giri: None. I. Sim: None. R.I. McLachlan: None. C.A. Allan: None. R. Upreti: None. Background: Klinefelter syndrome, the most common chromosomal disorder in men, remains underdiagnosed in many …

7119 Klinefelter Syndrome in a Tertiary Referral Clinic: A Case Series and Clinical Audit Open

Jinghang Luo, Stella Sarlos, Rinky Giri, Ie‐Wen Sim, Robert I. McLachlan , et al. · 2024

Disclosure: J. Luo: None. S. Sarlos: None. R. Giri: None. I. Sim: None. R.I. McLachlan: None. C.A. Allan: None. R. Upreti: None. Background: Klinefelter syndrome, the most common chromosomal disorder in men, remains underdiagnosed in many …

Morphology Classification of Live Unstained Human Sperm Using Ensemble Deep Learning Open

Sahar Shahali, Manzur Murshed, Spencer Lindsay, Ozlem Tunc, Ludmila Pisarevski , et al. · 2024

Sperm morphology analysis is crucial in infertility diagnosis and treatment. However, current clinical analytical methods use either chemical stains that render cells unusable for treatment or rely on subjective manual inspection. Here, an…

Undiagnosed RASopathies in infertile men Open

Anna-Grete Juchnewitsch, Kristjan Pomm, Avirup Dutta, Erik Tamp, Anu Valkna , et al. · 2024

RASopathies are syndromes caused by congenital defects in the Ras/mitogen-activated protein kinase (MAPK) pathway genes, with a population prevalence of 1 in 1,000. Patients are typically identified in childhood based on diverse characteri…

Hyaluronan Sperm Selection during ICSI (HA-ICSI) Increases Embryo Utilization in Couples with Male Factor Infertility Open

A. F. Williams, Sophie Popkiss, Fabrizzio Horta, Robert I. McLachlan, Deirdre Zander‐Fox , et al. · 2024

Background: Hyaluronan (HA) sperm selection, utilizing the affinity of mature sperm for HA, has emerged as a technique to enhance the selection of sperm for intracytoplasmic sperm injection (ICSI). However, conflicting evidence exists rega…

FRI439 Spermatogenesis Induction For Hypogonadotrophic Hypogonadism In An Australian Tertiary Hospital Andrology Service Open

Stella Sarlos, Madhuni Herath, Ie‐Wen Sim, Rita Upreti, Robert I. McLachlan , et al. · 2023

Disclosure: S. Sarlos: None. M. Herath: None. I. Sim: None. R. Upreti: None. R.I. McLachlan: None. C.A. Allan: None. Infertility affects 8-12% of couples with male factors contributing to 50% and solely responsible in 20-30% of cases. Male…

FRI434 Long-term Self-reported Outcomes Of Randomized Testosterone (T) vs Placebo (P) Treatment In The T4DM Study Open

David J. Handelsman, Mathis Grossmann, Bu B. Yeap, Bronwyn Stuckey, Nandini Shankara‐Narayana , et al. · 2023

Disclosure: D.J. Handelsman: None. M. Grossmann: None. B.B. Yeap: Consulting Fee; Self; Bayer, Inc., Lawley. Research Investigator; Self; Lawley. B.G. Stuckey: Speaker; Self; Lawley. N. Shankara-Narayana: None. A.J. Conway: None. W. Inder:…

Improved phenotypic classification of male infertility to promote discovery of genetic causes Open

Margot J. Wyrwoll, Godfried W. van der Heijden, Csilla Krausz, Kenneth I. Aston, Sabine Kliesch , et al. · 2023

Lifestyle and environmental risk factors for unexplained male infertility: study protocol for Australian Male Infertility Exposure (AMIE), a case–control study Open

Sarah N. Biggs, Joanne Kennedy, Sharon L. Lewis, Stephen Hearps, Moira K. O’Bryan , et al. · 2023

Diverse monogenic subforms of human spermatogenic failure Open

Liina Nagirnaja, Alexandra M. Lopes, Wu‐Lin Charng, Brian Miller, Rytis Stakaitis , et al. · 2022

Non-obstructive azoospermia (NOA) is the most severe form of male infertility and typically incurable. Defining the genetic basis of NOA has proven challenging, and the most advanced classification of NOA subforms is not based on genetics,…

Australian fertility preservation guidelines for people with cancer 2022: review and recommendations Open

Violet Kieu, Catharyn Stern, Jessica Harris, Yasmin Jayasinghe, Natalie Bradford , et al. · 2022

Best practice in oncofertility care requires structured referral pathways, with access to fertility preservation counselling and technology Fertility preservation is a rapidly advancing field, and new strategies are continuously being deve…

Standards in semen examination: publishing reproducible and reliable data based on high-quality methodology Open

Lars Björndahl, Christopher L. R. Barratt, David Mortimer, Ashok Agarwal, R. John Aitken , et al. · 2022

Biomedical science is rapidly developing in terms of more transparency, openness and reproducibility of scientific publications. This is even more important for all studies that are based on results from basic semen examination. Recently t…

Diverse Monogenic Subforms of Human Spermatogenic Failure Open

Liina Nagirnaja, Alexandra M. Lopes, Wu‐Lin Charng, Brian Miller, Rytis Stakaitis , et al. · 2022

Non-obstructive azoospermia (NOA) is the most severe form of male infertility and typically incurable with current medicine. Due to the biological complexity of sperm production, defining the genetic basis of NOA has proven challenging, an…

Are Clinical Outcomes of Micro-TESE in Non-obstructive Azoospermic Men Affected by the Use of Fresh or Frozen Gametes? Open

Fabrizzio Horta, Dhanushi Fernando, Daniel Lantsberg, Sandra Holden, Darren Katz , et al. · 2022

Background: The combination of microsurgical testicular sperm extraction (mTESE) and intracytoplasmic sperm injection (ICSI) has become a common management option, with sperm motility being positively associated with successful outcomes. H…

Recovery of Male Reproductive Endocrine Function Following Prolonged Injectable Testosterone Undecanoate Treatment Open

Nandini Shankara‐Narayana, Reena Desai, Ann J. Conway, Bronwyn Gwenneth Ann Stuckey, Warrick J. Inder , et al. · 2021

Background: Exogenous androgen treatment suppresses the hypothalamo-pituitary testicular (HPT) axis causing reduced serum LH, FSH and testosterone (T). Recovery of male reproductive endocrine function in past androgen abusers takes 9-18 mo…

Exome sequencing reveals variants in known and novel candidate genes for severe sperm motility disorders Open

Manon S. Oud, Brendan J. Houston, Ludmila Voložonoka, Francesco Mastrorosa, Giles Holt , et al. · 2021

STUDY QUESTION What are the causative genetic variants in patients with male infertility due to severe sperm motility disorders? SUMMARY ANSWER We identified high confidence disease-causing variants in multiple genes previously associated …

Lack of evidence for a role of PIWIL1 variants in human male infertility Open

Manon S. Oud, Ludmila Voložonoka, Corinna Friedrich, Sabine Kliesch, Liina Nagirnaja , et al. · 2021

Sperm proteins and cancer‐testis antigens are released by the seminiferous tubules in mice and men Open

Liza O’Donnell, Diane Rebourcet, Laura F. Dagley, Raouda Sgaier, Giuseppe Infusini , et al. · 2021

Sperm develop from puberty in the seminiferous tubules, inside the blood‐testis barrier to prevent their recognition as “non‐self” by the immune system, and it is widely assumed that human sperm‐specific proteins cannot access the circulat…

Inhibin physiology in the human female Open

Robert I. McLachlan · 2021

This thesis was scanned from the print manuscript for digital preservation and is copyright the author. Researchers can access this thesis by asking their local university, institution or public library to make a request on their behalf. M…

Covid-19: Spiking a focus on men’s health Open

Gary Wittert, Robert I. McLachlan · 2020

Chronic testicular Chlamydia muridarum infection impairs mouse fertility and offspring development† Open

Emily R. Bryan, Kate A. Redgrove, Alison R Mooney, Bettina P. Mihalas, Jessie M. Sutherland , et al. · 2020

With approximately 131 million new genital tract infections occurring each year, Chlamydia is the most common sexually transmitted bacterial pathogen worldwide. Male and female infections occur at similar rates and both cause serious patho…

Variants in <i>PIWIL1</i> Do Not Play a Major Role in Human Male Infertility Open

Manon S. Oud, Ludmila Voložonoka, Corinna Friedrich, Sabine Kliesch, Liina Nagirnaja , et al. · 2020

Health and fertility of ICSI-conceived young men: study protocol Open

Sarah R. Catford, Sharon Lewis, Jane Halliday, Joanne Kennedy, Moira K. O’Bryan , et al. · 2020

STUDY QUESTIONS What are the long-term health and reproductive outcomes for young men conceived using ICSI whose fathers had spermatogenic failure (STF)? Are there epigenetic consequences of ICSI conception? WHAT IS KNOWN ALREADY Currently…

Assisted reproductive technologies are associated with limited epigenetic variation at birth that largely resolves by adulthood Open

Boris Novakovic, Sharon Lewis, Jane Halliday, Joanne Kennedy, David Burgner , et al. · 2019

Detection of chlamydia infection within human testicular biopsies Open

Emily R. Bryan, Robert I. McLachlan, Luk Rombauts, Darren Katz, Anusch Yazdani , et al. · 2019

STUDY QUESTION Can Chlamydia be found in the testes of infertile men? SUMMARY ANSWER Chlamydia can be found in 16.7% of fresh testicular biopsies and 45.3% of fixed testicular biopsies taken from a selection of infertile men. WHAT IS KNOWN…

Recruitment of men to a multi-centre diabetes prevention trial: an evaluation of traditional and online promotional strategies Open

Karen Bracken, Wendy Hague, Anthony Keech, Ann J. Conway, David J. Handelsman , et al. · 2019

Acute myeloid leukaemia presenting with diabetes insipidus Open

M Bardin, David Ritchie, Robert I. McLachlan, Christopher J. Yates · 2019

A 41‐year‐old man was diagnosed with hypogonadotropic hypogonadism managed with gonadotropins after routine fertility review. Eight months later he presented with new polydipsia and polyuria, lethargy and easy bruising. A full blood count …

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