Robert J. Fieldhouse
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View article: A Machine Learning Approach for Hot-Spot Detection at Protein-Protein Interfaces
A Machine Learning Approach for Hot-Spot Detection at Protein-Protein Interfaces Open
Understanding protein-protein interactions is a key challenge in biochemistry. In this work, we describe a more accurate methodology to predict Hot-Spots (HS) in protein-protein interfaces from their native complex structure compared to pr…
View article: Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer
Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer Open
View article: EVfold.org: Evolutionary Couplings and Protein 3D Structure Prediction
EVfold.org: Evolutionary Couplings and Protein 3D Structure Prediction Open
Recently developed maximum entropy methods infer evolutionary constraints on protein function and structure from the millions of protein sequences available in genomic databases. The EVfold web server (at EVfold.org) makes these methods av…
View article: Author Index
Author Index Open
View article: Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer
Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer Open
Invasive lobular carcinoma (ILC) is the second most prevalent histologic subtype of invasive breast cancer. Here, we comprehensively profiled 817 breast tumors, including 127 ILC, 490 ductal (IDC), and 88 mixed IDC/ILC. Besides E-cadherin …