Robert J. Fontana
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View article: Editorial: Cephalosporin‐Induced Liver Injury—Interesting but Tricky. Authors' Reply
Editorial: Cephalosporin‐Induced Liver Injury—Interesting but Tricky. Authors' Reply Open
View article: Dapagliflozin-Associated Hepatotoxicity With a Positive Rechallenge
Dapagliflozin-Associated Hepatotoxicity With a Positive Rechallenge Open
Sodium glucose cotransporter 2 inhibitors are generally safe medications, with labelled indications for diabetes mellites, heart failure, and chronic kidney disease. We present a case of suspected dapagliflozin-induced liver injury in a 68…
View article: Clinical and Genetic Associations in Cephalosporin‐Induced Liver Injury: Insights From the Drug‐Induced Liver Injury Network
Clinical and Genetic Associations in Cephalosporin‐Induced Liver Injury: Insights From the Drug‐Induced Liver Injury Network Open
Introduction Cephalosporins are widely prescribed antibiotics due to their efficacy and safety. Although rare, idiosyncratic drug‐induced liver injury (DILI) has been reported with their use. Here, we characterise the clinical features and…
View article: Right versus Middle Hepatic Vein access and One-Year TIPS Outcomes
Right versus Middle Hepatic Vein access and One-Year TIPS Outcomes Open
Background This study evaluates one-year clinical outcomes of transjugular intrahepatic portosystemic shunt (TIPS) placement using a middle hepatic vein (MHV) versus right hepatic vein (RHV) access. Primary end points were shunt patency an…
View article: Does Prior Bariatric Surgery Predispose to Acetaminophen-Related Acute Liver Failure?
Does Prior Bariatric Surgery Predispose to Acetaminophen-Related Acute Liver Failure? Open
INTRODUCTION: Prior small studies have suggested that patients with prior metabolic and bariatric surgery (MBS) may have increased susceptibility to acetaminophen (APAP)-related acute liver failure/acute liver injury (ALF/ALI). The aim of …
View article: Serum proteomics of adults with acute liver failure provides mechanistic insights and attractive prognostic biomarkers
Serum proteomics of adults with acute liver failure provides mechanistic insights and attractive prognostic biomarkers Open
Acute liver failure (ALF) is a sudden, and severe condition associated with high fatality. More sensitive and specific prognostic scores are urgently needed to facilitate decision-making regarding liver transplantation in patients with ALF…
View article: Liver Injury due to Intravenous Methylprednisolone in the Drug‐Induced Liver Injury Network
Liver Injury due to Intravenous Methylprednisolone in the Drug‐Induced Liver Injury Network Open
Background and Aims Short courses of intravenous (iv) methylprednisolone (MP) can cause drug induced liver injury (DILI). The aim of this study was to assess the clinical features and HLA associations of MP‐related DILI enrolled in the US …
View article: Macrophage Therapy for Acute Liver Injury (MAIL): a study protocol for a phase 1 randomised, open-label, dose-escalation study to evaluate safety, tolerability and activity of allogeneic alternatively activated macrophages in patients with paracetamol-induced acute liver injury in the UK
Macrophage Therapy for Acute Liver Injury (MAIL): a study protocol for a phase 1 randomised, open-label, dose-escalation study to evaluate safety, tolerability and activity of allogeneic alternatively activated macrophages in patients with paracetamol-induced acute liver injury in the UK Open
Introduction Acute liver failure (ALF) has no effective treatment other than liver transplantation and is commonly caused by paracetamol overdose. New treatments are needed to treat and prevent ALF. Alternatively-activated macrophages (AAM…
View article: Calcitriol-Mediated Hypercalcemia Due to Liver Metastases in a Patient With Primary Pancreatic Neuroendocrine Tumor
Calcitriol-Mediated Hypercalcemia Due to Liver Metastases in a Patient With Primary Pancreatic Neuroendocrine Tumor Open
Hypercalcemia is most commonly associated with primary hyperparathyroidism or malignancy in the setting of elevated parathyroid hormone-related protein or bone metastases. Calcitriol (1,25-dihydroxyvitamin D)-mediated hypercalcemia is rare…
View article: Investigation of the Role of Chemical Analysis in Causality Assessment of Herbal and Dietary Supplement-Induced Liver Injury
Investigation of the Role of Chemical Analysis in Causality Assessment of Herbal and Dietary Supplement-Induced Liver Injury Open
View article: Genetic variants associated with immune-mediated liver injury from checkpoint inhibitors
Genetic variants associated with immune-mediated liver injury from checkpoint inhibitors Open
Background: The clinical features, liver histology, and genetic variants in 57 patients with moderate to severe immune-mediated liver injury from checkpoint inhibitors (ILICI) are presented. Methods: Between 2010 and 2022, 57 high-causalit…
View article: Estimated Exposure to 6 Potentially Hepatotoxic Botanicals in US Adults
Estimated Exposure to 6 Potentially Hepatotoxic Botanicals in US Adults Open
Importance Use of herbal and dietary supplements (HDSs) accounts for an increasing proportion of drug hepatotoxicity cases. Turmeric or curcumin, green tea extract, Garcinia cambogia , black cohosh, red yeast rice, and ashwagandha are the …
View article: Clinical characteristics and <scp>HLA</scp> associations of azithromycin‐induced liver injury
Clinical characteristics and <span>HLA</span> associations of azithromycin‐induced liver injury Open
Summary Background Azithromycin (AZ) is a widely used antibiotic. The aim of this study was to characterise the clinical features, outcomes, and HLA association in patients with drug‐induced liver injury (DILI) due to AZ. Methods The clini…
View article: Macrophage Therapy for Acute Liver Injury (MAIL): a Phase 1 Randomised, Open-Label, Dose-Escalation Study to Evaluate Safety, Tolerability, and Activity of Allogeneic Alternatively Activated Macrophages in Patients with Paracetamol-induced Acute Liver Injury
Macrophage Therapy for Acute Liver Injury (MAIL): a Phase 1 Randomised, Open-Label, Dose-Escalation Study to Evaluate Safety, Tolerability, and Activity of Allogeneic Alternatively Activated Macrophages in Patients with Paracetamol-induced Acute Liver Injury Open
Introduction Acute Liver Failure (ALF) has no effective treatment other than liver transplantation, and is commonly caused by paracetamol overdose. New treatments are needed to treat and prevent ALF. Alternatively activated macrophages (AA…
View article: <scp>Drug‐induced</scp> liver injury (<scp>DILI</scp>) ascribed to non‐steroidal anti‐inflammatory drugs (<scp>NSAIDs</scp>) in the <scp>USA</scp>—Update with genetic correlations
<span>Drug‐induced</span> liver injury (<span>DILI</span>) ascribed to non‐steroidal anti‐inflammatory drugs (<span>NSAIDs</span>) in the <span>USA</span>—Update with genetic correlations Open
Objective To describe patients with NSAID‐DILI, including genetic factors associated with idiosyncratic DILI. Methods In DILIN, subjects with presumed DILI are enrolled and followed for at least 6 months. Causality is adjudicated by a Delp…
View article: Amiodarone and Dronedarone Causes Liver Injury with Distinctly Different Clinical Presentations
Amiodarone and Dronedarone Causes Liver Injury with Distinctly Different Clinical Presentations Open
View article: Abstract No. 588 A Tale of Two Veins: Does the Right versus Middle Hepatic Vein Access Impact One-Year TIPS Patency?
Abstract No. 588 A Tale of Two Veins: Does the Right versus Middle Hepatic Vein Access Impact One-Year TIPS Patency? Open
View article: ERAP-1 and ERAP-2 Variants in Liver Injury After COVID-19 mRNA Vaccination: A US Multicenter Study
ERAP-1 and ERAP-2 Variants in Liver Injury After COVID-19 mRNA Vaccination: A US Multicenter Study Open
INTRODUCTION: The aim of this study is to describe the presenting features, genetic factors, and outcomes of 23 adults who developed liver injury after coronavirus disease 2019 (COVID-19) mRNA vaccination. METHODS: Patients with suspected …
View article: Immune-mediated liver injury from checkpoint inhibitors: Best practices in 2024
Immune-mediated liver injury from checkpoint inhibitors: Best practices in 2024 Open
View article: A High-Throughput Microphysiological Liver Chip System to Model Drug-Induced Liver Injury Using Human Liver Organoids
A High-Throughput Microphysiological Liver Chip System to Model Drug-Induced Liver Injury Using Human Liver Organoids Open
View article: Granulomatous hepatitis: Is it bugs, drugs, or other untoward culprits?
Granulomatous hepatitis: Is it bugs, drugs, or other untoward culprits? Open
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View article: A High-Throughput Microphysiological Liver Chip System to Model Direct and Idiosyncratic Drug-Induced Liver Injury Using Human Liver Organoids
A High-Throughput Microphysiological Liver Chip System to Model Direct and Idiosyncratic Drug-Induced Liver Injury Using Human Liver Organoids Open
1. Abstract Objective Drug-induced liver injury (DILI) is a major failure mode in pharmaceutical development. This study aims to address the limitations of existing preclinical models by introducing a high-throughput, microfluidic liver-on…
View article: Symptoms of Liver Disease During Tenofovir Therapy With or Without Peginterferon: Results from the Hepatitis B Research Network Immune Active Trial
Symptoms of Liver Disease During Tenofovir Therapy With or Without Peginterferon: Results from the Hepatitis B Research Network Immune Active Trial Open
View article: MELD 3.0 in Advanced Chronic Liver Disease
MELD 3.0 in Advanced Chronic Liver Disease Open
The MELD (model for end-stage liver disease) 3.0 score was developed to replace the MELD-Na score that is currently used to prioritize liver allocation for cirrhotic patients awaiting liver transplantation in the United States. The MELD 3.…
View article: Vancomycin-Induced Liver Injury, DRESS, and HLA-A∗32:01
Vancomycin-Induced Liver Injury, DRESS, and HLA-A∗32:01 Open
View article: Future directions in acute liver failure
Future directions in acute liver failure Open
Acute liver failure (ALF) describes a clinical syndrome of rapid hepatocyte injury leading to liver failure manifested by coagulopathy and encephalopathy in the absence of pre-existing cirrhosis. The hallmark diagnostic features are a prol…
View article: Safety and yield of percutaneous liver biopsy in adults and children with chronic hepatitis B: Results from a prospective, multicenter study
Safety and yield of percutaneous liver biopsy in adults and children with chronic hepatitis B: Results from a prospective, multicenter study Open
Background: Prospective data regarding the safety and yield of liver biopsy in both adults and children with chronic hepatitis B are limited. The aim of this study is to report safety, yield, and complication rates among adults and childre…
View article: Nomenclature, diagnosis and management of drug-induced autoimmune-like hepatitis (DI-ALH): An expert opinion meeting report
Nomenclature, diagnosis and management of drug-induced autoimmune-like hepatitis (DI-ALH): An expert opinion meeting report Open
View article: Racial Disparities in Treatment Initiation and Outcomes of Chronic Hepatitis B Virus Infection in North America
Racial Disparities in Treatment Initiation and Outcomes of Chronic Hepatitis B Virus Infection in North America Open
Importance Disparities in treatment initiation may affect outcomes, but data on racially diverse populations with chronic hepatitis B virus (HBV) infection are limited. Objective To examine whether HBV treatment initiation and outcomes dif…
View article: Advances in the management of idiosyncratic drug-induced liver injury
Advances in the management of idiosyncratic drug-induced liver injury Open
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