Robert J. Hardwick
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View article: A prevalence-based transmission model for the study of the epidemiology and control of soil-transmitted helminthiasis
A prevalence-based transmission model for the study of the epidemiology and control of soil-transmitted helminthiasis Open
Much effort has been devoted by the World Health Organization (WHO) to eliminate soil-transmitted helminth (STH) infections by 2030 using mass drug administration targeted at particular risk groups alongside the availability to access wate…
View article: What is the impact of acquired immunity on the transmission of schistosomiasis and the efficacy of current and planned mass drug administration programmes?
What is the impact of acquired immunity on the transmission of schistosomiasis and the efficacy of current and planned mass drug administration programmes? Open
Schistosomiasis causes severe morbidity in many countries with endemic infection with the schistosome digenean parasites in Africa and Asia. To control and eliminate the disease resulting from infection, regular mass drug administration (M…
View article: Spatial scales in human movement between reservoirs of infection
Spatial scales in human movement between reservoirs of infection Open
The life cycle of parasitic organisms that are the cause of much morbidity in humans often depend on reservoirs of infection for transmission into their hosts. Understanding the daily, monthly and yearly movement patterns of individuals be…
View article: Deworming women of reproductive age during adolescence and pregnancy: what is the impact on morbidity from soil-transmitted helminths infection?
Deworming women of reproductive age during adolescence and pregnancy: what is the impact on morbidity from soil-transmitted helminths infection? Open
Background Soil-transmitted helminths (STHs) are a major cause of poor health in low- and middle-income countries. In particular, hookworm is known to cause anaemia in children and women of reproductive age (WRA). One goal of the World Hea…
View article: umbralcalc/helmpy: Updated first release
umbralcalc/helmpy: Updated first release Open
helmpy is an all-in-one python class for optimised stochastic simulation and forecasting the effect of mass drug administration on helminth (parasitic worm) disease transmission. The public repository also contains tutorials in the form of…
View article: Deworming women of reproductive age during adolescence and pregnancy: what is the impact on morbidity from soil-transmitted helminths infection?
Deworming women of reproductive age during adolescence and pregnancy: what is the impact on morbidity from soil-transmitted helminths infection? Open
Background: Soil-transmitted helminths (STHs) are a major cause of poor health in low- and middle-income countries. In particular, hookworm is known to cause anaemia in children and women of reproductive age (WRA). One goal of the World He…
View article: Individual adherence to mass drug administration in neglected tropical disease control: A probability model conditional on past behaviour
Individual adherence to mass drug administration in neglected tropical disease control: A probability model conditional on past behaviour Open
We present a general framework which describes the systematic (binary) scenario of individuals either taking treatment or not for any reason, over the course of mass drug administration (MDA)—which we refer to as ‘adherence’ and ‘non-adher…
View article: Forecasting the effectiveness of the DeWorm3 trial in interrupting the transmission of soil-transmitted helminths in three study sites in Benin, India and Malawi
Forecasting the effectiveness of the DeWorm3 trial in interrupting the transmission of soil-transmitted helminths in three study sites in Benin, India and Malawi Open
View article: Stochastic challenges to interrupting helminth transmission
Stochastic challenges to interrupting helminth transmission Open
View article: Forecasting the effectiveness of the DeWorm3 trial in interrupting the transmission of soil-transmitted helminths in three study sites in Benin, India and Malawi
Forecasting the effectiveness of the DeWorm3 trial in interrupting the transmission of soil-transmitted helminths in three study sites in Benin, India and Malawi Open
Background The DeWorm3 project is an ongoing cluster-randomised trial assessing the feasibility of interrupting the transmission of soil-transmitted helminths (STH) through mass drug administration (MDA) using study sites in India, Malawi …
View article: Deworming women of reproductive age during adolescence and pregnancy: what is the impact on morbidity from soil-transmitted helminths infection?
Deworming women of reproductive age during adolescence and pregnancy: what is the impact on morbidity from soil-transmitted helminths infection? Open
Background: Soil-transmitted helminths (STHs) are a major cause of poor health in low- and middle-income countries. In particular, hookworm is known to cause anaemia in children and women of reproductive age (WRA). One goal of the World He…
View article: The impact of mass drug administration on Schistosoma haematobium infection: what is required to achieve morbidity control and elimination?
The impact of mass drug administration on Schistosoma haematobium infection: what is required to achieve morbidity control and elimination? Open
View article: Patterns of individual non-treatment during multiple rounds of mass drug administration for control of soil-transmitted helminths in the TUMIKIA trial, Kenya: a secondary longitudinal analysis
Patterns of individual non-treatment during multiple rounds of mass drug administration for control of soil-transmitted helminths in the TUMIKIA trial, Kenya: a secondary longitudinal analysis Open
Bill & Melinda Gates Foundation, Joint Global Health Trials Scheme of the Medical Research Council, UK Department for International Development, Wellcome Trust, Children's Investment Fund Foundation, and London Centre for Neglected Tropica…
View article: Deworming Women of Reproductive Age During Adolescence and Pregnancy: What is the Impact on Morbidity From Soil-transmitted Helminths Infection?
Deworming Women of Reproductive Age During Adolescence and Pregnancy: What is the Impact on Morbidity From Soil-transmitted Helminths Infection? Open
Background: Soil-transmitted helminths (STHs) are a major cause of poor health in low- and middle-income countries. In particular, hookworm is known to cause anaemia in children and women of reproductive age (WRA). One goal of the World He…
View article: Forecasting the Effectiveness of the DeWorm3 Trial in Interrupting the Transmission of Soil-transmitted Helminths in Three Study Sites in Benin, India and Malawi
Forecasting the Effectiveness of the DeWorm3 Trial in Interrupting the Transmission of Soil-transmitted Helminths in Three Study Sites in Benin, India and Malawi Open
Background The DeWorm3 project is an ongoing cluster-randomised trial assessing the feasibility of interrupting the transmission of soil-transmitted helminths (STH) through mass drug administration (MDA) using study sites in India, Malawi …
View article: Individual adherence to mass drug administration in neglected tropical disease control: a probability model conditional on past behaviour
Individual adherence to mass drug administration in neglected tropical disease control: a probability model conditional on past behaviour Open
We present a general framework which describes the systematic (binary) scenario of individuals either taking treatment or not for any reason, over the course of mass drug administration (MDA) — which we refer to as ‘adherence’ and ‘non-adh…
View article: Spatial scales in human movement between reservoirs of infection
Spatial scales in human movement between reservoirs of infection Open
The life cycle of parasitic organisms that are the cause of much morbidity in humans often depend on reservoirs of infection for transmission into their hosts. Understanding the daily, monthly and yearly movement patterns of individuals be…
View article: Stochastic challenges to interrupting helminth transmission
Stochastic challenges to interrupting helminth transmission Open
Predicting the effect of different programmes designed to control both the morbidity induced by helminth infections and parasite transmission is greatly facilitated by the use of mathematical models of transmission and control impact. In s…
View article: The ‘breakpoint’ of soil-transmitted helminths with infected human migration
The ‘breakpoint’ of soil-transmitted helminths with infected human migration Open
Building on past research, we here develop an analytic framework for describing the dynamics of the transmission of soil-transmitted helminth (STH) parasitic infections near the transmission breakpoint and equilibria of endemic infection a…
View article: Testing Inflationary Cosmology
Testing Inflationary Cosmology Open
In this thesis we will primarily demonstrate how additional scalar degrees of freedom - which are motivated from many high-energy embeddings - open up new observational windows onto the physics of inflation. We construct a Bayesian framewo…
View article: The ‘breakpoint’ in transmission for soil-transmitted helminths: dynamical behaviour near the equilibria and the impact of infected human migration
The ‘breakpoint’ in transmission for soil-transmitted helminths: dynamical behaviour near the equilibria and the impact of infected human migration Open
Building on past research, we here develop an analytic framework for describing the dynamics of the transmission of soil-transmitted helminth (STH) parasitic infections near the transmission breakpoint and equilibria of endemic infection a…
View article: Measuring the duration of inflation with the curvaton
Measuring the duration of inflation with the curvaton Open
Simple models of single-field inflation in the very early universe can generate the observed amplitude and scale dependence of the primordial density perturbation, but models with multiple fields can provide an equally good fit to current …
View article: The decisive future of inflation
The decisive future of inflation Open
How much more will we learn about single-field inflationary models in the future? We address this question in the context of Bayesian design and information theory. We develop a novel method to compute the expected utility of deciding betw…
View article: The stochastic spectator
The stochastic spectator Open
We study the stochastic distribution of spectator fields predicted in\ndifferent slow-roll inflation backgrounds. Spectator fields have a negligible\nenergy density during inflation but may play an important dynamical role later,\neven giv…
View article: A quantum window onto early inflation
A quantum window onto early inflation Open
Inflation in the early universe is one of the most promising probes of gravity in the high-energy regime. However, observable scales give access to a limited window in the inflationary dynamics. In this paper, we argue that quantum correct…
View article: Constraining curvatonic reheating
Constraining curvatonic reheating Open
We derive the first systematic observational constraints on reheating in models of inflation where an additional light scalar field contributes to primordial density perturbations and affects the expansion history during reheating. This en…