Robert J. Heine
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View article: Striving for early effective glycaemic and weight management in type 2 diabetes: A narrative review
Striving for early effective glycaemic and weight management in type 2 diabetes: A narrative review Open
Despite the recognition by key guidelines that achieving early glycaemic control has important benefits in individuals with type 2 diabetes (T2D) and that addressing excess adiposity is one of the central components of comprehensive person…
View article: Early-onset type 2 diabetes and tirzepatide treatment: a post hoc analysis from the SURPASS clinical trial program
Early-onset type 2 diabetes and tirzepatide treatment: a post hoc analysis from the SURPASS clinical trial program Open
Objective: We evaluated baseline characteristics of participants with early-onset T2D from the SURPASS program and tirzepatide’s effects on glycemic control, body weight (BW), and cardiometabolic markers. Research Design and Methods: This …
View article: Early-onset type 2 diabetes and tirzepatide treatment: a post hoc analysis from the SURPASS clinical trial program
Early-onset type 2 diabetes and tirzepatide treatment: a post hoc analysis from the SURPASS clinical trial program Open
Objective: We evaluated baseline characteristics of participants with early-onset T2D from the SURPASS program and tirzepatide’s effects on glycemic control, body weight (BW), and cardiometabolic markers. Research Design and Methods: This …
View article: Early-Onset Type 2 Diabetes and Tirzepatide Treatment: A Post Hoc Analysis From the SURPASS Clinical Trial Program
Early-Onset Type 2 Diabetes and Tirzepatide Treatment: A Post Hoc Analysis From the SURPASS Clinical Trial Program Open
OBJECTIVE We evaluated baseline characteristics of participants with early-onset type 2 diabetes (T2D) from the SURPASS program and tirzepatide’s effects on glycemic control, body weight (BW), and cardiometabolic markers. RESEARCH DESIGN A…
View article: Safety and efficacy analyses across age and body mass index subgroups in East Asian participants with type 2 diabetes in the phase 3 tirzepatide studies ( <scp>SURPASS</scp> programme)
Safety and efficacy analyses across age and body mass index subgroups in East Asian participants with type 2 diabetes in the phase 3 tirzepatide studies ( <span>SURPASS</span> programme) Open
Aim To assess the safety and efficacy of tirzepatide in people of East Asian descent based on age and body mass index (BMI). Materials and Methods Data of participants enrolled in East Asian countries in the SURPASS‐1, ‐3, ‐4, ‐5, J‐mono a…
View article: The European Diabetes Forum (EUDF): a forum for turning the tide on diabetes in Europe
The European Diabetes Forum (EUDF): a forum for turning the tide on diabetes in Europe Open
View article: Risk Factors Associated with COVID-19 Hospitalization and Mortality: A Large Claims-Based Analysis Among People with Type 2 Diabetes Mellitus in the United States
Risk Factors Associated with COVID-19 Hospitalization and Mortality: A Large Claims-Based Analysis Among People with Type 2 Diabetes Mellitus in the United States Open
View article: Evaluating glucose‐lowering treatment in older people with diabetes: Lessons from the IMPERIUM trial
Evaluating glucose‐lowering treatment in older people with diabetes: Lessons from the IMPERIUM trial Open
Understanding the benefits and risks of treatments to be used by older individuals (≥65 years old) is critical for informed therapeutic decisions. Glucose‐lowering therapy for older patients with diabetes should be tailored to suit their c…
View article: Privatkopie Im Digitalen Zeitalter (Private Copying in the Digital Age)
Privatkopie Im Digitalen Zeitalter (Private Copying in the Digital Age) Open
View article: Review for "Prediction and validation of exenatide risk marker effects on progression of renal disease: Insights from EXSCEL"
Review for "Prediction and validation of exenatide risk marker effects on progression of renal disease: Insights from EXSCEL" Open
View article: The Effect of Non-penicillin Antibiotic Regimens on Neonatal Outcomes in Preterm Premature Rupture of Membranes
The Effect of Non-penicillin Antibiotic Regimens on Neonatal Outcomes in Preterm Premature Rupture of Membranes Open
Objective A 7-day course of a penicillin (PCN) and macrolide is standard of care (SAR) in preterm premature rupture of membranes (PPROM). Data regarding alternative antibiotic regimens are limited. We sought to assess the impact of non-PCN…
View article: Reduced Glucose Variability With Glucose-Dependent Versus Glucose-Independent Therapies Despite Similar Glucose Control and Hypoglycemia Rates in a Randomized, Controlled Study of Older Patients With Type 2 Diabetes Mellitus
Reduced Glucose Variability With Glucose-Dependent Versus Glucose-Independent Therapies Despite Similar Glucose Control and Hypoglycemia Rates in a Randomized, Controlled Study of Older Patients With Type 2 Diabetes Mellitus Open
Background: Few studies have evaluated continuous glucose monitoring (CGM) in older patients with type 2 diabetes mellitus (T2DM) not using injectable therapy. CGM is useful for investigating hypoglycemia and glycemic variability, which is…
View article: Glycaemic outcomes of an <scp>I</scp> ndividualized treat <scp>M</scp> ent a <scp>P</scp> proach for old <scp>ER</scp> vulnerable pat <scp>I</scp> ents: <scp>A</scp> randomized, controlled st <scp>U</scp> dy in type 2 diabetes <scp>M</scp> ellitus ( <scp>IMPERIUM</scp> )
Glycaemic outcomes of an <span>I</span> ndividualized treat <span>M</span> ent a <span>P</span> proach for old <span>ER</span> vulnerable pat <span>I</span> ents: <span>A</span> randomized, controlled st <span>U</span> dy in type 2 diabetes <span>M</span> ellitus ( <span>IMPERIUM</span> ) Open
Aims To compare the glycaemic outcomes of 2 glucose‐lowering treatment strategies in vulnerable (moderately ill and/or frail) patients aged ≥65 years with type 2 diabetes whose individual HbA1c targets were not met with diet/exercise and/o…
View article: Closed-Incision Negative-Pressure Therapy in Obese Patients Undergoing Cesarean Delivery: A Randomized Controlled Trial
Closed-Incision Negative-Pressure Therapy in Obese Patients Undergoing Cesarean Delivery: A Randomized Controlled Trial Open
Background Postcesarean wound morbidity is a costly complication of cesarean delivery for which preventative strategies remain understudied. Objective We compared surgical site occurrences (SSOs) in cesarean patients receiving closed-incis…
View article: Exenatide improves β-cell function up to 3 years of treatment in patients with type 2 diabetes: a randomised controlled trial
Exenatide improves β-cell function up to 3 years of treatment in patients with type 2 diabetes: a randomised controlled trial Open
Objective Glucagon-like peptide (GLP)-1 receptor agonist treatment improves β-cell function. In this study, we investigated whether the improvements are sustained during a 3-year treatment period. Research design and methods Sixty-nine met…
View article: Perspectives on Some Controversies in Cardiovascular Disease Risk Assessment in the Pharmaceutical Development of Glucose-Lowering Medications
Perspectives on Some Controversies in Cardiovascular Disease Risk Assessment in the Pharmaceutical Development of Glucose-Lowering Medications Open
The U.S. Food and Drug Administration (FDA) issued guidance on requirements to assess cardiovascular disease (CVD) risk with drugs being developed for approval for clinical use. The guidance was triggered by a meta-analysis published by Ni…
View article: Effect of diabetes on caregiver burden in an observational study of individuals with Alzheimer’s disease
Effect of diabetes on caregiver burden in an observational study of individuals with Alzheimer’s disease Open
View article: Effect of 3 Years of Treatment With Exenatide on Postprandial Glucagon Levels
Effect of 3 Years of Treatment With Exenatide on Postprandial Glucagon Levels Open
α-Cell dysfunction contributes to hyperglycemia in type 2 diabetes and is characterized by inappropriately increased basal and postprandial glucagon levels (1). The regulation of glucagon secretion remains poorly understood. Glucagon-like …
View article: Erratum to: Associations Between Glycemic Control, Depressed Mood, Clinical Depression, and Diabetes Distress Before and After Insulin Initiation: An Exploratory, Post Hoc Analysis
Erratum to: Associations Between Glycemic Control, Depressed Mood, Clinical Depression, and Diabetes Distress Before and After Insulin Initiation: An Exploratory, Post Hoc Analysis Open
View article: Associations Between Glycemic Control, Depressed Mood, Clinical Depression, and Diabetes Distress Before and After Insulin Initiation: An Exploratory, Post Hoc Analysis
Associations Between Glycemic Control, Depressed Mood, Clinical Depression, and Diabetes Distress Before and After Insulin Initiation: An Exploratory, Post Hoc Analysis Open