Robert J. Holtackers
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View article: Artificial Intelligence-Based Arterial Input Function for the Quantitative Assessment of Myocardial Blood Flow and Perfusion Reserve in Cardiac Magnetic Resonance: A Validation Study
Artificial Intelligence-Based Arterial Input Function for the Quantitative Assessment of Myocardial Blood Flow and Perfusion Reserve in Cardiac Magnetic Resonance: A Validation Study Open
Background/Objectives: To validate an artificial intelligence-based arterial input function (AI-AIF) deep learning model for myocardial blood flow (MBF) quantification during stress perfusion and assess its extension to rest perfusion, ena…
View article: Visualization of monopolar biphasic focal pulsed field ablation lesions 3 months after pulmonary vein isolation on high-resolution 3-dimensional dark-blood late gadolinium enhancement cardiac magnetic resonance images
Visualization of monopolar biphasic focal pulsed field ablation lesions 3 months after pulmonary vein isolation on high-resolution 3-dimensional dark-blood late gadolinium enhancement cardiac magnetic resonance images Open
Left atrial regions that were ablated with monopolar F-PFA have a significantly higher IIR than nonablated regions with 1.08 as the optimal IIR threshold to distinguish between ablated and nonablated regions.
View article: Cardiac Function Assessment with Deep-Learning-Based Automatic Segmentation of Free-Running 4D Whole-Heart CMR
Cardiac Function Assessment with Deep-Learning-Based Automatic Segmentation of Free-Running 4D Whole-Heart CMR Open
Background Free-running (FR) cardiac MRI enables free-breathing ECG-free fully dynamic 5D (3D spatial+cardiac+respiration dimensions) imaging but poses significant challenges for clinical integration due to the volume and complexity of ima…
View article: Optimal image intensity ratio threshold for atrial focal monopolar pulsed field ablation lesions assessment by dark-blood late gadolinium enhancement cardiac magnetic resonance imaging
Optimal image intensity ratio threshold for atrial focal monopolar pulsed field ablation lesions assessment by dark-blood late gadolinium enhancement cardiac magnetic resonance imaging Open
Background Dark-blood late gadolinium enhancement cardiac magnetic resonance imaging (LGE CMR) has been used to assess ablation lesions after pulmonary vein isolation (PVI) by thermal energy sources (cryo and radiofrequency) with an optima…
View article: Static and dynamic abnormalities in electromechanical and autonomic cardiac function characterize the proarrhythmic substrate in the long-QT syndrome
Static and dynamic abnormalities in electromechanical and autonomic cardiac function characterize the proarrhythmic substrate in the long-QT syndrome Open
Background Arrhythmogenesis in long-QT syndrome (LQTS) is driven by electrical instabilities, proarrhythmic electromechanical reciprocity, and swift autonomic nervous system (ANS) fluctuations. Purpose Characterizing the proarrhythmic elec…
View article: Influence of Reader Expertise on Myocardial Infarction Detection
Influence of Reader Expertise on Myocardial Infarction Detection Open
Objectives: This study aimed to evaluate the influence of reader training and experience on the detection of (small) myocardial infarctions (MIs) and the assessment of ischemic scar transmurality using dark-blood late gadolinium enhancemen…
View article: Novel systematic processing of cardiac magnetic resonance imaging identifies target regions associated with infarct-related ventricular tachycardia
Novel systematic processing of cardiac magnetic resonance imaging identifies target regions associated with infarct-related ventricular tachycardia Open
Aims There is lack of agreement on late gadolinium enhancement cardiac magnetic resonance (LGE-CMR) imaging processing for guiding ventricular tachycardia (VT) ablation. We aim at developing and validating a systematic processing approach …
View article: Free-Running Cardiac and Respiratory Motion-Resolved Imaging: A Paradigm Shift for Managing Motion in Cardiac MRI?
Free-Running Cardiac and Respiratory Motion-Resolved Imaging: A Paradigm Shift for Managing Motion in Cardiac MRI? Open
Cardiac magnetic resonance imaging (MRI) is widely used for non-invasive assessment of cardiac morphology, function, and tissue characteristics due to its exquisite soft-tissue contrast. However, it remains time-consuming and requires prof…
View article: Automated cardiovascular MR myocardial scar quantification with unsupervised domain adaptation
Automated cardiovascular MR myocardial scar quantification with unsupervised domain adaptation Open
Quantification of myocardial scar from late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) images can be facilitated by automated artificial intelligence (AI)-based analysis. However, AI models are susceptible to doma…
View article: Molecular imaging of coronary plaque vulnerability using 18F- fluorocholine PET-MRI in patients with coronary artery disease: validation with optical coherence tomography
Molecular imaging of coronary plaque vulnerability using 18F- fluorocholine PET-MRI in patients with coronary artery disease: validation with optical coherence tomography Open
Purpose 18F-fluorocholine is a positron emission tomography (PET) tracer earlier found to be a marker of macrophage content in carotid plaques. We aimed to assess the feasibility of 18F-choline PET-MRI to non-invasively localize vulnerable…
View article: Novel systematic processing of cardiac magnetic resonance imaging identifies target regions associated with infarct-related ventricular tachycardia
Novel systematic processing of cardiac magnetic resonance imaging identifies target regions associated with infarct-related ventricular tachycardia Open
Introduction In the clinic, complete characterization of reentrant ventricular tachycardia (VT) circuits using classical electrophysiological criteria and state-of-the-art high density mapping during VT is complex, and often cannot be comp…
View article: Deep Learning Synthesis of White-Blood From Dark-Blood Late Gadolinium Enhancement Cardiac Magnetic Resonance
Deep Learning Synthesis of White-Blood From Dark-Blood Late Gadolinium Enhancement Cardiac Magnetic Resonance Open
Objectives Dark-blood late gadolinium enhancement (DB-LGE) cardiac magnetic resonance has been proposed as an alternative to standard white-blood LGE (WB-LGE) imaging protocols to enhance scar-to-blood contrast without compromising scar-to…
View article: Quantification of myocardial scar of different etiology using dark- and bright-blood late gadolinium enhancement cardiovascular magnetic resonance
Quantification of myocardial scar of different etiology using dark- and bright-blood late gadolinium enhancement cardiovascular magnetic resonance Open
Dark-blood late gadolinium enhancement (LGE) has been shown to improve the visualization and quantification of areas of ischemic scar compared to standard bright-blood LGE. Recently, the performance of various semi-automated quantification…
View article: Tissue characterization of acute lesions during cardiac magnetic resonance-guided ablation of cavo-tricuspid isthmus-dependent atrial flutter: a feasibility study
Tissue characterization of acute lesions during cardiac magnetic resonance-guided ablation of cavo-tricuspid isthmus-dependent atrial flutter: a feasibility study Open
Aims To characterize acute lesions during cardiac magnetic resonance (CMR)-guided radiofrequency (RF) ablation of cavo-tricuspid isthmus (CTI)-dependent atrial flutter by combining T2-weighted imaging (T2WI), T1 mapping, first-pass perfusi…
View article: Optimal pixel signal intensity threshold for the assessment of endocardial left-ventricular scar by 3D dark blood MRI compared to bipolar voltage electro-anatomical mapping
Optimal pixel signal intensity threshold for the assessment of endocardial left-ventricular scar by 3D dark blood MRI compared to bipolar voltage electro-anatomical mapping Open
Background Late gadolinium enhancement (LGE) MRI is considered the standard for noninvasive assessment of 3D scar architecture. Intraprocedural integration of 3D scar models improve the outcome of catheter ablation for ventricular tachycar…
View article: Tissue characterisation of acute ablation lesions in the right atrium during CMR-guided atrial flutter ablation
Tissue characterisation of acute ablation lesions in the right atrium during CMR-guided atrial flutter ablation Open
Funding Acknowledgements Type of funding sources: None. Background Cardiac magnetic resonance (CMR)-guided ablation therapy offers a unique opportunity and incentive to investigate acute ablation lesions. Until present, human studies only …
View article: Dark-Blood Late Gadolinium Enhancement MRI Is Noninferior to Bright-Blood LGE in Non-Ischemic Cardiomyopathies
Dark-Blood Late Gadolinium Enhancement MRI Is Noninferior to Bright-Blood LGE in Non-Ischemic Cardiomyopathies Open
(1) Background and Objectives: Dark-blood late gadolinium enhancement has been shown to be a reliable cardiac magnetic resonance (CMR) method for assessing viability and depicting myocardial scarring in ischemic cardiomyopathy. The aim of …
View article: Myocardial Scar Detection Using High-Resolution Free-Breathing 3D Dark-Blood and Standard Breath-Holding 2D Bright-Blood Late Gadolinium Enhancement MRI: A Comparison of Observer Confidence
Myocardial Scar Detection Using High-Resolution Free-Breathing 3D Dark-Blood and Standard Breath-Holding 2D Bright-Blood Late Gadolinium Enhancement MRI: A Comparison of Observer Confidence Open
Objective: To compare observer confidence for myocardial scar detection using 3 different late gadolinium enhancement (LGE) data sets by 2 observers with different levels of experience. Materials and Methods: Forty-one consecutive patients…