Explanipedia

Corrigendum to ‘Primary percutaneous stenting for palliative biliary drainage of patients with malignant hilar biliary obstruction: TESLA trial’ [JHEP Reports 7 (2025) 101541] Open

Stijn Franssen, Merve Rousian, Victorien van Verschuer, Marco Brayda‐Bruno, Michail Doukas , et al. · 2025

Hypothermic oxygenated perfusion (HOPE) against cancer recurrence after liver transplantation for hepatocellular carcinoma—study protocol for an international multicenter randomized controlled trial (HOPE4Cancer) Open

Janina Eden, Philip C. Müller, Christoph Kuemmerli, Florian Peters, Tanja Litke , et al. · 2025

Background A frequent and increasing indication for liver transplantation (LT) is hepatocellular carcinoma (HCC). However, despite strict selection criteria, HCC recurrence after LT occurs in a relevant proportion of patients and is associ…

Primary percutaneous stenting for palliative biliary drainage of patients with malignant hilar biliary obstruction: TESLA trial Open

Stijn Franssen, Merve Rousian, Victorien van Verschuer, Marco Brayda‐Bruno, Michail Doukas , et al. · 2025

Posttransplant Dynamics of Serum T50 and Coronary Artery Calcium Scores Among Kidney Transplant Recipients Open

Amarens van der Vaart, Daan Kremer, Edward R. Smith, Rozemarijn Vliegenthart, Andreas Pasch , et al. · 2025

Life Expectancy of Transplanted Livers Open

Janina Eden, Philip C. Müller, Christoph Kuemmerli, Noa L E Aegerter, Isabel M.A. Brüggenwirth , et al. · 2025

Objective: To investigate the impact of cumulative liver age on graft survival in liver transplant recipients. Background: Organ shortage has led to increased use of elderly donor livers for an ageing group of recipients, particularly in E…

Long-term Follow-up After Hypothermic Oxygenated Machine Perfusion in DCD Liver Transplantation Open

Rianne van Rijn, Chikako Endo, Efrayim H. Küçükerbil, Hans Blokzijl, Joris Blondeel , et al. · 2025

Background and Aim: Transplantation of livers from donation after circulatory death (DCD) donors is associated with an increased risk of nonanastomotic biliary strictures (NAS). Dual hypothermic oxygenated machine perfusion (DHOPE) of dono…

Transplantation of Severely Steatotic Liver Grafts After Machine Perfusion Remains a Risky Challenge Open

Riccardo Cirelli, Adam M. Thorne, Otto B. van Leeuwen, Bianca Lascaris, Veerle A. Lantinga , et al. · 2025

Liver transplantation is the treatment of choice for patients with end‐stage liver disease. However, donor shortages have increased the use of high‐risk and extended criteria donor livers, including livers donated after circulatory death a…

Developing an Adult Living Donor Liver Transplant Program in Western Europe: The Rotterdam Experience Open

Alicia J. Chorley, Wojciech G. Polak, Khe C. K. Tran, Türkan Terkivatan, Jorge Juan Olsina Kissler , et al. · 2025

Liver transplantation (LT) is curative for end stage liver disease. Expanding LT indications with limited deceased donor grafts has created organ shortages. Living donor liver transplant (LDLT) increases available organs. In 2019, we resta…

Therapeutic hyperthermia promotes lipid export and <span>HSP70</span>/90 during machine perfusion of human livers Open

Adam M. Thorne, Yana Geng, Veerle A. Lantinga, Marieke Smit, Jan Albert Kuivenhoven , et al. · 2025

Liver transplantation is the only curative option for end‐stage liver disease. Donor shortages necessitate the use of higher risk donor livers, including fatty livers, which are more susceptible to ischemia‐reperfusion injury. Machine perf…

Metabolic balance of human livers during long-term normothermic machine perfusion Open

Bianca Lascaris, Linda C. Woltjes, Silke B. Bodewes, Robert J. Porte, Vincent E. de Meijer , et al. · 2025

A long-term normothermic machine perfusion platform is being developed for repairing and regenerating damaged livers to make them suitable for transplantation. The energy expenditure and the metabolic needs of 14 human donor livers were ob…

Limited Risk of Microbial Contamination During Hypothermic and Normothermic Machine Perfusion of Donor Kidneys Open

Julia S. Slagter, Carolina A. M. Schurink, Ga‐Lai M. Chong, Marlies E. J. Reinders, Robert J. Porte , et al. · 2025

Background Both hypothermic machine perfusion (HMP) and normothermic machine perfusion (NMP) are increasingly used for preservation of deceased donor kidneys. However, especially NMP can pose as a risk for microbial contamination of the ki…

Long‐Term Liver Machine Perfusion Preservation: A Review of Recent Advances, Benefits and Logistics Open

Juliana Pavan‐Guimaraes, Lene Devos, Bianca Lascaris, Vincent E. de Meijer, Diethard Monbaliu , et al. · 2025

Background The global shortage of suitable donor livers for transplantation has prompted efforts to expand the donor pool by using extended criteria donors. Machine preservation technology has shown promise in optimizing graft preservation…

Perfusion Pressures and Weight Loss During Normothermic Machine Perfusion of Human Donor Livers Open

Bianca Lascaris, Silke B. Bodewes, Adam M. Thorne, Marius C. van den Heuvel, Robbert J. de Haas , et al. · 2024

Background Normothermic machine perfusion (NMP) is increasingly used to preserve and assess donor livers prior to transplantation. Due to its success, it is expected that more centers will start using this technology. However, NMP may also…

Dynamic Preservation of Donation After Circulatory Death Liver Grafts From Donors Aged 60 y and Older Open

Joris Blondeel, Otto B. van Leeuwen, Ivo J. Schurink, Veerle A. Lantinga, Nicholas Gilbo , et al. · 2024

Background. Donor livers from older donation after circulatory death (DCD) donors are frequently discarded for transplantation because of the high risk of graft failure. It is unknown whether DCD livers from older donors benefit from dynam…

The caveat of biliary pH as biomarker of bile duct viability during normothermic machine perfusion of donor livers Open

Bianca Lascaris, Puck C. Groen, Silke B. Bodewes, Roberto Broere, Otto B. van Leeuwen , et al. · 2024

Muscle Mass, Muscle Strength, and Health-Related Quality of Life in Kidney Transplant Recipients Open

Tim J. Knobbe, Gijs M.M. Lenis, Dirk A.J. van der Vossen, Jory Wentink, Daan Kremer , et al. · 2024

Cost-effectiveness of Dual Hypothermic Oxygenated Machine Perfusion Versus Static Cold Storage in DCD Liver Transplantation Open

Chikako Endo, Rianne van Rijn, Volkert A.L. Huurman, Ivo J. Schurink, Aad van den Berg , et al. · 2024

Background. Ex situ machine perfusion of the donor liver, such as dual hypothermic oxygenated machine perfusion (DHOPE), is increasingly used in liver transplantation. Although DHOPE reduces ischemia/reperfusion-related complications after…

Assessment of liver graft quality during hypothermic oxygenated perfusion: The first international validation study Open

J. Eden, Adam M. Thorne, Silke B. Bodewes, Damiano Patrono, Dorotea Roggio , et al. · 2024

Comparative Analysis of Digestion Methods for Bile Proteomics: The Key to Unlocking Biliary Biomarker Potential Open

Adam M. Thorne, Martijn Hoekzema, Robert J. Porte, Folkert Kuipers, Vincent E. de Meijer , et al. · 2024

Variability between methods emphasizes the importance of cross-validation across multiple analytical approaches to ensure robust analysis. We recommend the in-gel crude method for its simplicity and efficiency, avoiding additional precipit…

Production of physiological amounts of hemostatic proteins by human donor livers during ex situ long-term normothermic machine perfusion for up to 7 days Open

Bianca Lascaris, Silke B. Bodewes, Jelle Adelmeijer, Maarten W. Nijsten, Robert J. Porte , et al. · 2024

Hepatocellular adenomas with severe intra-abdominal bleeding, related to an underlying coagulation disorder: a case report Open

Christiaan A. J. Oudmaijer, Joost Sprakel, Dave Sprengers, K. A. Wiese, N. Vogelaar - Tintel , et al. · 2024

Background Hepatocellular adenoma is a rare benign liver tumor. Typically, hepatocellular adenomas are solitary and are found in young women who use estrogen-containing contraceptives. The occurrence of multiple hepatocellular adenoma has …

Long-term outcomes after hypothermic oxygenated machine perfusion and transplantation of 1,202 donor livers in a real-world setting (HOPE-REAL study) Open

Janina Eden, Isabel M.A. Brüggenwirth, Gabriela Berlakovich, Bettina M. Buchholz, Florin Botea , et al. · 2024

Oxygenated versus non‐oxygenated flush out during deceased donor liver procurement: The first proof‐of‐concept study in humans Open

Eduardo de Souza Martins Fernandes, R Correa, Rodrigo Lopes Leite Furtado, Isabel M.A. Brüggenwirth, Cindy Yang , et al. · 2024

Background Liver transplantation is used for treating end‐stage liver disease, fulminant hepatitis, and oncological malignancies and organ shortage is a major limiting factor worldwide. The use of grafts based on extended donor criteria ha…

The Risk of Microbial Transmission in Recipients of Donor Livers That Underwent Hypothermic or Normothermic Machine Perfusion Open

Chikako Endo, Bianca Lascaris, Isabel M.A. Brüggenwirth, Jan Roggeveld, Hans Blokzijl , et al. · 2024

Background. Ex situ machine perfusion is increasingly used to preserve and assess donor livers before transplantation. Compared with traditional static cold storage (SCS), machine perfusion exposes livers to an additional risk of microbial…

Viability assessment of the liver during ex-situ machine perfusion prior to transplantation Open

Puck C. Groen, Otto B. van Leeuwen, Jeroen de Jonge, Robert J. Porte · 2024

Purpose of review In an attempt to reduce waiting list mortality in liver transplantation, less-than-ideal quality donor livers from extended criteria donors are increasingly accepted. Predicting the outcome of these organs remains a chall…

Graft repair during machine perfusion: a current overview of strategies Open

Roberto Broere, Stefan H. Luijmes, Jeroen de Jonge, Robert J. Porte · 2024

Purpose of review With changing donor characteristics (advanced age, obesity), an increase in the use of extended criteria donor (ECD) livers in liver transplantation is seen. Machine perfusion allows graft viability assessment, but still …

The gut microbiome in end-stage lung disease and lung transplantation Open

S. Zhang, J. Casper Swarte, Ranko Gaćeša, Tim J. Knobbe, Daan Kremer , et al. · 2024

Gut dysbiosis has been associated with impaired outcomes in liver and kidney transplant recipients, but the gut microbiome of lung transplant recipients has not been extensively explored. We assessed the gut microbiome in 64 fecal samples …

Type of calcineurin inhibitor and long-term outcomes following liver transplantation in patients with primary biliary cholangitis – an ELTR study Open

Maria C. van Hooff, Rozanne C. de Veer, Vincent Karam, René Adam, Pavel Taimr , et al. · 2024

Clinical Safety and Performance of GATT-Patch for Hemostasis in Minimal to Moderate Bleeding During Open Liver Surgery Open

Johannes H.W. de Wilt, Cornelis Verhoef, Marieke T. de Boer, Martijn W.J. Stommel, Leanne van der Plas-Kemper , et al. · 2024

Iron deficiency, anemia, and patient-reported outcomes in kidney transplant recipients Open

Daan Kremer, Tim J. Knobbe, Joanna Sophia J. Vinke, Dion Groothof, Adrian Post , et al. · 2024

Robert J. Porte YOU? Author Swipe