Reinhard Bauer
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View article: Distinct Effects of Aging and Klotho Deletion on the Choroid Plexus
Distinct Effects of Aging and Klotho Deletion on the Choroid Plexus Open
Klotho (Kl) is an anti-aging protein primarily produced in the kidney and the choroid plexus (CP, where it regulates cerebrospinal fluid composition and exerts neuroprotective effects. Here, we investigated the age-dependent consequences o…
View article: Hypoxia Supports LPS-Driven Tolerance and Functional Activation in BV-2 Microglial Cells
Hypoxia Supports LPS-Driven Tolerance and Functional Activation in BV-2 Microglial Cells Open
Background: Prolonged hypoxia contributes to irreversible organ damage, particularly in the brain and heart. While chronic hypoxia is harmful, mild short-term hypoxia can trigger protective mechanisms. This study investigates how such hypo…
View article: Atrial fibrillation, sinoatrial and atrioventricular node dysfunction in a mouse model of heart failure with preserved ejection fraction
Atrial fibrillation, sinoatrial and atrioventricular node dysfunction in a mouse model of heart failure with preserved ejection fraction Open
Millions of people are affected by atrial fibrillation (AF) and heart failure with preserved ejection fraction (HFpEF), two disorders frequently found simultaneously. However, the interrelationship between these intertwined disorders is po…
View article: Sciatic nerve analysis in thyroid hormone transporters Mct8 and Oatp1c1 knockout mice
Sciatic nerve analysis in thyroid hormone transporters Mct8 and Oatp1c1 knockout mice Open
Objective Mutations in the thyroid hormone (TH) transporter monocarboxylate transporter 8 ( MCT8 ) cause Allan–Herndon–Dudley syndrome (AHDS), a severe form of psychomotor retardation with muscle hypoplasia and spastic paraplegia as key sy…
View article: Largely ignored—but pathogenetically significant: ambient temperature in rodent sepsis models
Largely ignored—but pathogenetically significant: ambient temperature in rodent sepsis models Open
View article: Metamizole outperforms meloxicam in sepsis: insights on analgesics, survival and immunomodulation in the peritoneal contamination and infection sepsis model
Metamizole outperforms meloxicam in sepsis: insights on analgesics, survival and immunomodulation in the peritoneal contamination and infection sepsis model Open
Background Limited availability and side effects of opioids have led to an increased use of non-opioid analgesia in animal disease models. However, by affecting the immune-inflammatory reactions, analgesia may disrupt the resolution of the…
View article: Impact of inflammatory preconditioning on murine microglial proteome response induced by focal ischemic brain injury
Impact of inflammatory preconditioning on murine microglial proteome response induced by focal ischemic brain injury Open
Preconditioning with lipopolysaccharide (LPS) induces neuroprotection against subsequent cerebral ischemic injury, mainly involving innate immune pathways. Microglia are resident immune cells of the central nervous system (CNS) that respon…
View article: Neuropathological changes in the TASTPM mouse model of Alzheimer’s disease and their relation to hyperexcitability and cortical spreading depolarization
Neuropathological changes in the TASTPM mouse model of Alzheimer’s disease and their relation to hyperexcitability and cortical spreading depolarization Open
View article: Design-Dependent Electrophysiological Effects of Electrolysis Electrodes Used for Endodontic Disinfection
Design-Dependent Electrophysiological Effects of Electrolysis Electrodes Used for Endodontic Disinfection Open
Electrochemical disinfection in dentistry using boron-doped diamond (BDD) electrodes bears the potential risk of disturbing vital functions. Applying different arrays of BDD electrodes and an electrotome as reference, it was the goal of th…
View article: Investigating the role of CCL11 in shaping microglial age-and long-Covid-related inflammatory activation
Investigating the role of CCL11 in shaping microglial age-and long-Covid-related inflammatory activation Open
View article: Successful treatment of pulmonary hypertension and right heart failure by antibody-based functional blocking of the extra-domain A of fibronectin in a preclinical animal model
Successful treatment of pulmonary hypertension and right heart failure by antibody-based functional blocking of the extra-domain A of fibronectin in a preclinical animal model Open
Background Pulmonary Hypertension (PH) as heterogeneous disease group is pathogenetically accompanied by pulmonary vascular and right ventricular tissue remodelling showing similarities between the clinical groups 1 (Pulmonary Arterial Hyp…
View article: Proteomic analysis of peripheral nerve myelin during murine aging
Proteomic analysis of peripheral nerve myelin during murine aging Open
Aging of the peripheral nervous system (PNS) is associated with structural and functional changes that lead to a reduction in regenerative capacity and the development of age-related peripheral neuropathy. Myelin is central to maintaining …
View article: Cortical spreading depolarization is a potential target for rat brain excitability modulation by Galanin
Cortical spreading depolarization is a potential target for rat brain excitability modulation by Galanin Open
View article: Autism Spectrum Disorder: A Neuro-Immunometabolic Hypothesis of the Developmental Origins
Autism Spectrum Disorder: A Neuro-Immunometabolic Hypothesis of the Developmental Origins Open
Fetal neuroinflammation and prenatal stress (PS) may contribute to lifelong neurological disabilities. Astrocytes and microglia, among the brain’s non-neuronal “glia” cell populations, play a pivotal role in neurodevelopment and predisposi…
View article: Proteomic analysis of peripheral nerve myelin during murine aging
Proteomic analysis of peripheral nerve myelin during murine aging Open
Aging of the peripheral nervous system (PNS) is associated with structural and functional changes that lead to a reduction in regenerative capacity and the development of age-related peripheral neuropathy. Myelin is central to maintaining …
View article: Impact of inflammatory preconditioning on murine microglial proteome response induced by focal ischemic brain injury
Impact of inflammatory preconditioning on murine microglial proteome response induced by focal ischemic brain injury Open
Preconditioning with LPS induces neuroprotection against subsequent cerebral ischemic injury, mainly involving innate immune pathways. Microglia are CNS-resident immune cells that respond early to danger signals through memory-like differe…
View article: Training vs. Tolerance: The Yin/Yang of the Innate Immune System
Training vs. Tolerance: The Yin/Yang of the Innate Immune System Open
For almost nearly a century, memory functions have been attributed only to acquired immune cells. Lately, this paradigm has been challenged by an increasing number of studies revealing that innate immune cells are capable of exhibiting mem…
View article: Targeted Interleukin‐9 delivery in pulmonary hypertension: Comparison of immunocytokine formats and effector cell study
Targeted Interleukin‐9 delivery in pulmonary hypertension: Comparison of immunocytokine formats and effector cell study Open
Aims Pulmonary hypertension (PH) is accompanied by pulmonary vascular remodelling. By targeted delivery of Interleukin‐9 (IL9) via the immunocytokine F8IL9, beneficial effects could be demonstrated in a mouse model of PH. This study aimed …
View article: Ezrin deficiency triggers glial fibrillary acidic protein upregulation and a distinct reactive astrocyte phenotype
Ezrin deficiency triggers glial fibrillary acidic protein upregulation and a distinct reactive astrocyte phenotype Open
Astrocytes are increasingly being recognized as contributors to physiological brain function and behavior. Astrocytes engage in glia‐synaptic interactions through peripheral astrocyte processes, thus modulating synaptic signaling, for exam…
View article: Mouse sepsis models: don't forget ambient temperature!
Mouse sepsis models: don't forget ambient temperature! Open
View article: From spreading depolarization to epilepsy with neuroinflammation: The role of CGRP in cortex
From spreading depolarization to epilepsy with neuroinflammation: The role of CGRP in cortex Open
CGRP release plays a major role in migraine pain by activating the trigeminal pain pathways. Here we explored putative additional effects of CGRP on cortical circuits and investigated whether CGRP affects cortical excitability, cortical sp…
View article: Distinct Actions of the Thyroid Hormone Transporters Mct8 and Oatp1c1 in Murine Adult Hippocampal Neurogenesis
Distinct Actions of the Thyroid Hormone Transporters Mct8 and Oatp1c1 in Murine Adult Hippocampal Neurogenesis Open
Inactivating mutations in the thyroid hormone (TH) transporter monocarboxylate transporter 8 (MCT8) result in Allan-Herndon-Dudley Syndrome, a severe form of psychomotor retardation, while inactivating mutations in another TH transporter, …
View article: Crucial role of extra-domain A containing fibronectin for the development of pulmonary hypertension and associated right heart failure
Crucial role of extra-domain A containing fibronectin for the development of pulmonary hypertension and associated right heart failure Open
Background Pulmonary vascular and right ventricular myocardial remodelling are unique phenomena in PH progression. Both processes are accompanied by an abundant re-expression of the extra-domain A of fibronectin (ED-A+ Fn) therefore qualif…
View article: PI3Kγ Mediates Microglial Proliferation and Cell Viability via ROS
PI3Kγ Mediates Microglial Proliferation and Cell Viability via ROS Open
(1) Background: Rapid microglial proliferation contributes to the complex responses of the innate immune system in the brain to various neuroinflammatory stimuli. Here, we investigated the regulatory function of phosphoinositide 3-kinase γ…
View article: Update to the dataset of cerebral ischemia in juvenile pigs with evoked potentials
Update to the dataset of cerebral ischemia in juvenile pigs with evoked potentials Open
View article: Targeted delivery of a phosphoinositide 3‐kinase γ inhibitor to restore organ function in sepsis
Targeted delivery of a phosphoinositide 3‐kinase γ inhibitor to restore organ function in sepsis Open
View article: The Role of the Pathogen Dose and PI3Kγ in Immunometabolic Reprogramming of Microglia for Innate Immune Memory
The Role of the Pathogen Dose and PI3Kγ in Immunometabolic Reprogramming of Microglia for Innate Immune Memory Open
Microglia, the innate immune cells of the CNS, exhibit long-term response changes indicative of innate immune memory (IIM). Our previous studies revealed IIM patterns of microglia with opposing immune phenotypes: trained immunity after a l…
View article: Targeted delivery of a phosphoinositide 3-kinase γ inhibitor to restore organ function in sepsis through dye-functionalized lipid nanocarriers
Targeted delivery of a phosphoinositide 3-kinase γ inhibitor to restore organ function in sepsis through dye-functionalized lipid nanocarriers Open
Jaundice, the clinical hallmark of infection-associated liver dysfunction, reflects altered membrane organization of the canalicular pole of hepatocytes and portends poor outcomes. Mice lacking phosphoinositide 3-kinase-γ (PI3Kγ) are prote…
View article: Multimodal pathophysiological dataset of gradual cerebral ischemia in a cohort of juvenile pigs
Multimodal pathophysiological dataset of gradual cerebral ischemia in a cohort of juvenile pigs Open
View article: Update on the multimodal pathophysiological dataset of gradual cerebral ischemia in a cohort of juvenile pigs: auditory, sensory and high-frequency sensory evoked potentials
Update on the multimodal pathophysiological dataset of gradual cerebral ischemia in a cohort of juvenile pigs: auditory, sensory and high-frequency sensory evoked potentials Open
Building upon the previously shared data set, here we expand from a spontaneous to an evoked responses data set containing brain electrical activities in the form of electrocorticogram (ECOG) and electrothalamogram (EThG). This evoked resp…