Robert J. Tower
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View article: Osteoprogenitor cells from non-regenerative bone show greater resistance to cellular stress than those from regenerative bone
Osteoprogenitor cells from non-regenerative bone show greater resistance to cellular stress than those from regenerative bone Open
Introduction Bone regeneration following injury depends on osteoprogenitor cells derived predominantly from the periosteum. Incomplete regeneration has been attributed to both cell-extrinsic factors (e.g., environment, inflammation, mechan…
View article: The tectum transversum(TTR) maintains patency of the developing coronal suture
The tectum transversum(TTR) maintains patency of the developing coronal suture Open
Craniosynostosis is a congenital defect characterized by the premature fusion of calvarial bones, often attributed to the loss of fibrous sutures or deregulated bone formation. Recent studies have reported abnormal cartilage formation in m…
View article: Spatial Transcriptomics Reveals Inflammation and Trans-differentiation States of Acute Myeloid Leukemia in Extramedullary and Medullary Tissues
Spatial Transcriptomics Reveals Inflammation and Trans-differentiation States of Acute Myeloid Leukemia in Extramedullary and Medullary Tissues Open
Acute myeloid leukemia (AML) is a heterogeneous disease of the bone marrow (medullary) but can also involve extramedullary tissues. While single cell dynamics of AML in suspension are previously explored, a comprehensive spatial transcript…
View article: Spatial transcriptomics implicates impaired BMP signaling in NF1 fracture pseudarthrosis in murine and patient tissues
Spatial transcriptomics implicates impaired BMP signaling in NF1 fracture pseudarthrosis in murine and patient tissues Open
The neurofibromatosis type 1 (NF1) RASopathy is associated with persistent fibrotic nonunions (pseudarthrosis) in human and mouse skeletal tissue. Here, we performed spatial transcriptomics to define the molecular signatures occurring duri…
View article: The Mohawk homeobox gene represents a marker and osteo-inhibitory factor in calvarial suture osteoprogenitor cells
The Mohawk homeobox gene represents a marker and osteo-inhibitory factor in calvarial suture osteoprogenitor cells Open
The regeneration of the mammalian skeleton’s craniofacial bones necessitates the action of intrinsic and extrinsic inductive factors from multiple cell types, which function hierarchically and temporally to control the differentiation of o…
View article: Mapping Somatosensory Afferent Circuitry to Bone Identifies Neurotrophic Signals Required for Fracture Healing
Mapping Somatosensory Afferent Circuitry to Bone Identifies Neurotrophic Signals Required for Fracture Healing Open
Summary The profound pain accompanying bone fracture is mediated by somatosensory neurons, which also appear to be required to initiate bone regeneration following fracture. Surprisingly, the precise neuroanatomical circuitry mediating ske…
View article: 09. Single-cell And Spatiotemporal Transcriptomics Of Volumetric Muscle Loss Highlights Discoidin Domain Receptor 2 Expression In Fibroadipogenic Progenitors
09. Single-cell And Spatiotemporal Transcriptomics Of Volumetric Muscle Loss Highlights Discoidin Domain Receptor 2 Expression In Fibroadipogenic Progenitors Open
Purpose: Muscle has the remarkable ability to regenerate small defects, however, when the defect is large, the injured tissue results in fibrosis. Fibrotic volumetric muscle loss (VML) injuries are painful and result in dysfunctional muscl…
View article: Vegfc-expressing cells form heterotopic bone after musculoskeletal injury
Vegfc-expressing cells form heterotopic bone after musculoskeletal injury Open
Heterotopic ossification (HO) is a challenging condition that occurs after musculoskeletal injury and is characterized by the formation of bone in non-skeletal tissues. While the effect of HO on blood vessels is well established, little is…
View article: The HIF-1α/PLOD2 axis integrates extracellular matrix organization and cell metabolism leading to aberrant musculoskeletal repair
The HIF-1α/PLOD2 axis integrates extracellular matrix organization and cell metabolism leading to aberrant musculoskeletal repair Open
While hypoxic signaling has been shown to play a role in many cellular processes, its role in metabolism-linked extracellular matrix (ECM) organization and downstream processes of cell fate after musculoskeletal injury remains to be determ…
View article: Itaconate-producing neutrophils regulate local and systemic inflammation following trauma
Itaconate-producing neutrophils regulate local and systemic inflammation following trauma Open
Modulation of the immune response to initiate and halt the inflammatory process occurs both at the site of injury as well as systemically. Due to the evolving role of cellular metabolism in regulating cell fate and function, tendon injurie…
View article: Tppp3+ synovial/tendon sheath progenitor cells contribute to heterotopic bone after trauma
Tppp3+ synovial/tendon sheath progenitor cells contribute to heterotopic bone after trauma Open
Heterotopic ossification (HO) is a pathological process resulting in aberrant bone formation and often involves synovial lined tissues. During this process, mesenchymal progenitor cells undergo endochondral ossification. Nonetheless, the s…
View article: Neutrophil and NETosis Modulation in Traumatic Heterotopic Ossification
Neutrophil and NETosis Modulation in Traumatic Heterotopic Ossification Open
Objective: To characterize the role of neutrophil extracellular traps (NETs) in heterotopic ossification (HO) formation and progression and to use mechanical and pharmacological methods to decrease NETosis and mitigate HO formation. Backgr…
View article: 11. Mesenchymal Lineage Discoidin Domain Receptor 2 Affects Heterotopic Ossification Formation and Extracellular Matrix Organization
11. Mesenchymal Lineage Discoidin Domain Receptor 2 Affects Heterotopic Ossification Formation and Extracellular Matrix Organization Open
PURPOSE: Heterotopic ossification (HO) is the formation of ectopic bone in the soft tissues of the musculoskeletal system following burn and blast wounds. Recent studies highlighted the necessity for mechanotransductive (FAK/YAP/TAZ) signa…
View article: Data from NELL1 Regulates the Matrisome to Promote Osteosarcoma Progression
Data from NELL1 Regulates the Matrisome to Promote Osteosarcoma Progression Open
Sarcomas produce an abnormal extracellular matrix (ECM), which in turn provides instructive cues for cell growth and invasion. Neural EGF like-like molecule 1 (NELL1) is a secreted glycoprotein characterized by its nonneoplastic osteoinduc…
View article: Data from NELL1 Regulates the Matrisome to Promote Osteosarcoma Progression
Data from NELL1 Regulates the Matrisome to Promote Osteosarcoma Progression Open
Sarcomas produce an abnormal extracellular matrix (ECM), which in turn provides instructive cues for cell growth and invasion. Neural EGF like-like molecule 1 (NELL1) is a secreted glycoprotein characterized by its nonneoplastic osteoinduc…
View article: Supplementary Figure from NELL1 Regulates the Matrisome to Promote Osteosarcoma Progression
Supplementary Figure from NELL1 Regulates the Matrisome to Promote Osteosarcoma Progression Open
Supplementary Figure from NELL1 Regulates the Matrisome to Promote Osteosarcoma Progression
View article: Supplementary Figure from NELL1 Regulates the Matrisome to Promote Osteosarcoma Progression
Supplementary Figure from NELL1 Regulates the Matrisome to Promote Osteosarcoma Progression Open
Supplementary Figure from NELL1 Regulates the Matrisome to Promote Osteosarcoma Progression
View article: Supplementary Data from NELL1 Regulates the Matrisome to Promote Osteosarcoma Progression
Supplementary Data from NELL1 Regulates the Matrisome to Promote Osteosarcoma Progression Open
Supplementary Data from NELL1 Regulates the Matrisome to Promote Osteosarcoma Progression
View article: Supplementary Data from NELL1 Regulates the Matrisome to Promote Osteosarcoma Progression
Supplementary Data from NELL1 Regulates the Matrisome to Promote Osteosarcoma Progression Open
Supplementary Data from NELL1 Regulates the Matrisome to Promote Osteosarcoma Progression
View article: Discoidin domain receptor 2 regulates aberrant mesenchymal lineage cell fate and matrix organization
Discoidin domain receptor 2 regulates aberrant mesenchymal lineage cell fate and matrix organization Open
Extracellular matrix (ECM) interactions regulate both the cell transcriptome and proteome, thereby determining cell fate. Traumatic heterotopic ossification (HO) is a disorder characterized by aberrant mesenchymal lineage (MLin) cell diffe…