Robert T. Jensen
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View article: Current Medical Controversies in Zollinger–Ellison Syndrome
Current Medical Controversies in Zollinger–Ellison Syndrome Open
Purpose: Zollinger–Ellison syndrome (ZES) is the most frequent, functional, malignant pancreatic neuroendocrine tumor syndrome (pNET), which is due to ectopic secretion of gastrin by a pNET/NET (i.e., gastrinomas) resulting in severe, refr…
View article: Bombesin receptors in GtoPdb v.2025.3
Bombesin receptors in GtoPdb v.2025.3 Open
Mammalian bombesin (Bn) receptors comprise 3 subtypes: BB1, BB2, BB3 (nomenclature recommended by the NC-IUPHAR Subcommittee on bombesin receptors, [118, 5]). BB1 and BB2 are activated by the endogenous ligands neuromedin B (NMB), gastrin-…
View article: Class A Orphans in GtoPdb v.2025.3
Class A Orphans in GtoPdb v.2025.3 Open
Table 1 lists a number of putative GPCRs identified by NC-IUPHAR [206], for which preliminary evidence for an endogenous ligand has been published, or for which there exists a potential link to a disease, or disorder. These GPCRs have rece…
View article: Gastrin-Releasing Peptide Receptors Stimulate MAPK-Mediated Growth of Lung Cancer Cells by Transactivating HER4 in a Neuregulin-1, MAP Kinase-Dependent Manner Requiring Activation of the ROS-System
Gastrin-Releasing Peptide Receptors Stimulate MAPK-Mediated Growth of Lung Cancer Cells by Transactivating HER4 in a Neuregulin-1, MAP Kinase-Dependent Manner Requiring Activation of the ROS-System Open
The bombesin (Bn) receptor family [Gastrin-releasing peptide (GRPR/BB2R) and Neuromedin B receptors (NMBR/BB1R)] are G-protein coupled receptors (GPCR’s) with potent growth effects on normal tissues/numerous cancers, often by transactivati…
View article: Enhancements to Mini-RF X/C-band data quality through cross-channel calibration and reprocessing strategies
Enhancements to Mini-RF X/C-band data quality through cross-channel calibration and reprocessing strategies Open
Since 2009, the Mini-RF synthetic aperture radar (SAR) onboard NASA’s Lunar Reconnaissance Orbiter (LRO) has been collecting both S-band (12.6 cm) or X/C-band (4.2 cm) observations to provide near-global coverage of the Moon, including lar…
View article: Class A Orphans in GtoPdb v.2025.2
Class A Orphans in GtoPdb v.2025.2 Open
Table 1 lists a number of putative GPCRs identified by NC-IUPHAR [197], for which preliminary evidence for an endogenous ligand has been published, or for which there exists a potential link to a disease, or disorder. These GPCRs have rece…
View article: Elucidation of roles of serine/threonine phosphatases PP1 and PP2A in mediating CCK-stimulated growth and enzyme secretion in pancreatic acinar cells
Elucidation of roles of serine/threonine phosphatases PP1 and PP2A in mediating CCK-stimulated growth and enzyme secretion in pancreatic acinar cells Open
Despite more than 10 studies, the roles of the serine/threonine phosphatases, PP1/PP2A, in pancreatic acinar cell-secretion/growth remain controversial. This study demonstrates that both PP1/PP2A are present in rat pancreatic acini and in …
View article: Class A Orphans in GtoPdb v.2025.1
Class A Orphans in GtoPdb v.2025.1 Open
Table 1 lists a number of putative GPCRs identified by NC-IUPHAR [164], for which preliminary evidence for an endogenous ligand has been published, or for which there exists a potential link to a disease, or disorder. These GPCRs have rece…
View article: Bombesin Receptor Subtype-3 Regulates Tumor Growth by HER2 Tyrosine Phosphorylation in a Reactive Oxygen Species-Dependent Manner in Lung Cancer Cells
Bombesin Receptor Subtype-3 Regulates Tumor Growth by HER2 Tyrosine Phosphorylation in a Reactive Oxygen Species-Dependent Manner in Lung Cancer Cells Open
Bombesin receptor subtype-3 (BRS-3) is a type 1 G-protein-coupled receptor (GPCR). BRS-3 is an orphan GPCR that is structurally related to neuromedin B and gastrin-releasing peptide receptors. When activated, BRS-3 causes phosphatidylinosi…
View article: The Important Role of p21-Activated Kinases in Pancreatic Exocrine Function
The Important Role of p21-Activated Kinases in Pancreatic Exocrine Function Open
The p21-activated kinases (PAKs) are a conserved family of serine/threonine protein kinases, which are effectors for the Rho family GTPases, namely, Rac/Cdc42. PAKs are divided into two groups: group I (PAK1–3) and group II (PAK4–6). Both …
View article: Long-Term Proton Pump Inhibitor–Acid Suppressive Treatment Can Cause Vitamin B12 Deficiency in Zollinger–Ellison Syndrome (ZES) Patients
Long-Term Proton Pump Inhibitor–Acid Suppressive Treatment Can Cause Vitamin B12 Deficiency in Zollinger–Ellison Syndrome (ZES) Patients Open
Whether the long-term treatment of patients with proton pump inhibitors (PPIs) with different diseases [GERD, Zollinger–Ellison syndrome (ZES), etc.] can result in vitamin B12 (VB12) deficiency is controversial. In this study, in 175 patie…
View article: Mechanistic rationale for ketene formation during vaping
Mechanistic rationale for ketene formation during vaping Open
Ketene is one of the most toxic vaping emissions identified to date. However, its high reactivity renders it relatively challenging to identify. In addition, theoretical studies show that realistic vaping temperature settings are too low t…
View article: Blood-based Transcriptomic and Proteomic Biomarkers of Emphysema
Blood-based Transcriptomic and Proteomic Biomarkers of Emphysema Open
Rationale: Emphysema is a chronic obstructive pulmonary disease phenotype with important prognostic implications. Identifying blood-based biomarkers of emphysema will facilitate early diagnosis and development of targeted therapies. Object…
View article: The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors
The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors Open
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 600…
View article: Mechanistic rationale for ketene formation during vaping
Mechanistic rationale for ketene formation during vaping Open
Ketene is one of the most toxic vaping emissions identified to date. However, its high reactivity renders it relatively challenging to identify. In addition, theoretical studies show that realistic vaping temperature settings are too low t…
View article: Peptide G-Protein-Coupled Receptors and ErbB Receptor Tyrosine Kinases in Cancer
Peptide G-Protein-Coupled Receptors and ErbB Receptor Tyrosine Kinases in Cancer Open
The ErbB RTKs (EGFR, HER2, HER3, and HER4) have been well-studied in cancer. EGFR, HER2, and HER3 stimulate cancer proliferation, principally by activating the phosphatidylinositol-3-kinase and extracellular signal-regulated kinase (ERK) p…
View article: Causes of and Clinical Features Associated with Death in Tobacco Cigarette Users by Lung Function Impairment
Causes of and Clinical Features Associated with Death in Tobacco Cigarette Users by Lung Function Impairment Open
Rationale: Cigarette smoking contributes to the risk of death through different mechanisms. Objectives: To determine how causes of and clinical features associated with death vary in tobacco cigarette users by lung function impairment. Met…
View article: Bombesin receptors in GtoPdb v.2023.1
Bombesin receptors in GtoPdb v.2023.1 Open
Mammalian bombesin (Bn) receptors comprise 3 subtypes: BB1, BB2, BB3 (nomenclature recommended by the NC-IUPHAR Subcommittee on bombesin receptors, [117, 4]). BB1 and BB2 are activated by the endogenous ligands neuromedin B (NMB), gastrin-…
View article: Class A Orphans in GtoPdb v.2023.1
Class A Orphans in GtoPdb v.2023.1 Open
Table 1 lists a number of putative GPCRs identified by NC-IUPHAR [161], for which preliminary evidence for an endogenous ligand has been published, or for which there exists a potential link to a disease, or disorder. These GPCRs have rece…
View article: Cofilin activation in pancreatic acinar cells plays a pivotal convergent role for mediating CCK-stimulated enzyme secretion and growth
Cofilin activation in pancreatic acinar cells plays a pivotal convergent role for mediating CCK-stimulated enzyme secretion and growth Open
Introduction: The actin regulatory protein, cofilin plays a key signaling role in many cells for numerous cellular responses including in proliferation, development, motility, migration, secretion and growth. In the pancreas it is importan…
View article: Successful Lifetime/Long-Term Medical Treatment of Acid Hypersecretion in Zollinger-Ellison Syndrome (ZES): Myth or Fact? Insights from an Analysis of Results of NIH Long-Term Prospective Studies of ZES
Successful Lifetime/Long-Term Medical Treatment of Acid Hypersecretion in Zollinger-Ellison Syndrome (ZES): Myth or Fact? Insights from an Analysis of Results of NIH Long-Term Prospective Studies of ZES Open
Analysis of the efficacy/pharmacology of long-term/lifetime medical treatment of acid hypersecretion in a large cohort of ZES patients in a prospective study. This study includes the results from all 303 patients with established ZES who w…
View article: Class A Orphans in GtoPdb v.2022.3
Class A Orphans in GtoPdb v.2022.3 Open
Table 1 lists a number of putative GPCRs identified by NC-IUPHAR [161], for which preliminary evidence for an endogenous ligand has been published, or for which there exists a potential link to a disease, or disorder. These GPCRs have rece…
View article: Vaping Cannabinoid Acetates Leads to Ketene Formation
Vaping Cannabinoid Acetates Leads to Ketene Formation Open
Delta-8 THC acetate is a relatively new psychoactive cannabis product that is available online and in vape shops across the US since it is currently unregulated. Because it contains a similar substructure to vitamin E acetate, which has be…
View article: Vaping Cannabinoid Acetates Leads to Ketene Formation
Vaping Cannabinoid Acetates Leads to Ketene Formation Open
Delta-8 THC acetate is a relatively new psychoactive cannabis product that is available online and in vape shops across the US since it is currently unregulated. Because it contains a similar substructure to vitamin E acetate, which has be…
View article: Goupil Premium Sales
Goupil Premium Sales Open
Goupil premium purchases and sales by decade.
View article: Knoedler Premium Sales
Knoedler Premium Sales Open
The premium sales data for the Knoedler Gallery organized by decade.
View article: Predictive Factors for Resistant Disease with Medical/Radiologic/Liver-Directed Anti-Tumor Treatments in Patients with Advanced Pancreatic Neuroendocrine Neoplasms: Recent Advances and Controversies
Predictive Factors for Resistant Disease with Medical/Radiologic/Liver-Directed Anti-Tumor Treatments in Patients with Advanced Pancreatic Neuroendocrine Neoplasms: Recent Advances and Controversies Open
Purpose: Recent advances in the diagnosis, management and nonsurgical treatment of patients with advanced pancreatic neuroendocrine neoplasms (panNENs) have led to an emerging need for sensitive and useful prognostic factors for predicting…