Robert Kupper
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View article: Oxidation Rates and Redox Stabilization of Ferrous Iron in Trioctahedral Smectites
Oxidation Rates and Redox Stabilization of Ferrous Iron in Trioctahedral Smectites Open
Iron(II)-bearing trioctahedral smectites (saponites) form during anoxic alteration of basaltic rock. They are predicted to have been widespread on the early Earth and are observed in the oceanic subsurface today. Smectite structures, inclu…
View article: Biological Oxidation of Fe(II)-Bearing Smectite by Microaerophilic Iron Oxidizer <i>Sideroxydans lithotrophicus</i> Using Dual Mto and Cyc2 Iron Oxidation Pathways
Biological Oxidation of Fe(II)-Bearing Smectite by Microaerophilic Iron Oxidizer <i>Sideroxydans lithotrophicus</i> Using Dual Mto and Cyc2 Iron Oxidation Pathways Open
Fe(II) clays are common across many environments, making them a potentially significant microbial substrate, yet clays are not well established as an electron donor. Therefore, we explored whether Fe(II)-smectite supports the growth of Sid…
View article: Synthesis and characterization of Fe(III)-Fe(II)-Mg-Al smectite solid solutions and implications for planetary science
Synthesis and characterization of Fe(III)-Fe(II)-Mg-Al smectite solid solutions and implications for planetary science Open
This study demonstrates the synergies and limits of multiple measurement types for the detection of smectite chemistry and oxidation state on planetary surfaces to infer past geochemical conditions. Smectite clay minerals are common produc…
View article: Randomized, Double-Blind, Placebo-Controlled, Flexible-Dose Titration Study of Methylphenidate Hydrochloride Extended-Release Capsules (Aptensio XR) in Preschool Children with Attention-Deficit/Hyperactivity Disorder
Randomized, Double-Blind, Placebo-Controlled, Flexible-Dose Titration Study of Methylphenidate Hydrochloride Extended-Release Capsules (Aptensio XR) in Preschool Children with Attention-Deficit/Hyperactivity Disorder Open
Objectives: To assess the efficacy and safety of a methylphenidate hydrochloride extended-release capsule (MPH-MLR) formulation in treating attention-deficit/hyperactivity disorder (ADHD) in preschool children. Methods: Children aged 4 to …
View article: Characteristics of ADHD Symptom Response/Remission in a Clinical Trial of Methylphenidate Extended Release
Characteristics of ADHD Symptom Response/Remission in a Clinical Trial of Methylphenidate Extended Release Open
Clinical trials in attention-deficit/hyperactivity disorder (ADHD) have typically measured outcome using clinician ratings on the Attention-Deficit/Hyperactivity Disorder Rating Scale, Fourth Edition (ADHD-RS-IV) and the Clinical Global Im…
View article: Relationship Between Symptomatic and Functional Improvement and Remission in a Treatment Response to Stimulant Trial
Relationship Between Symptomatic and Functional Improvement and Remission in a Treatment Response to Stimulant Trial Open
Children and adolescents treated with MPH-MLR showed moderate-to-large improvement in functioning during 3 months of treatment, both overall and in specific domains. However, a significant number of those who would be considered symptomati…
View article: Effect of Aptensio XR (Methylphenidate HCl Extended-Release) Capsules on Sleep in Children with Attention-Deficit/Hyperactivity Disorder
Effect of Aptensio XR (Methylphenidate HCl Extended-Release) Capsules on Sleep in Children with Attention-Deficit/Hyperactivity Disorder Open
In both studies, there was minimal negative impact of MPH-MLR on sleep during the brief DB phase and none during the longer duration OL phase. Some measures of sleep improved with optimized MPH-MLR dose.
View article: Population pharmacokinetics of methylphenidate hydrochloride extended-release multiple-layer beads in pediatric subjects with attention deficit hyperactivity disorder
Population pharmacokinetics of methylphenidate hydrochloride extended-release multiple-layer beads in pediatric subjects with attention deficit hyperactivity disorder Open
A new multilayer-bead formulation of extended-release methylphenidate hydrochloride (MPH-MLR) has been evaluated in pharmacokinetic studies in healthy adults and in Phase III efficacy/safety studies in children and adolescents with attenti…
View article: Efficacy of Methylphenidate Hydrochloride Extended-Release Capsules (Aptensio XR™) in Children and Adolescents with Attention-Deficit/Hyperactivity Disorder: A Phase III, Randomized, Double-Blind Study
Efficacy of Methylphenidate Hydrochloride Extended-Release Capsules (Aptensio XR™) in Children and Adolescents with Attention-Deficit/Hyperactivity Disorder: A Phase III, Randomized, Double-Blind Study Open
Dose-related improvements in ADHD-RS-IV scores that exceeded those of placebo were observed in patients treated with MPH-MLR. No new safety signals were noted.