Robert L. Elliott
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View article: Evaluating the CRP Interactome: Insights into Possible Novel Roles in Cellular Signaling and Tumorigenicity
Evaluating the CRP Interactome: Insights into Possible Novel Roles in Cellular Signaling and Tumorigenicity Open
C-reactive protein (CRP) is a well-known acute phase reactant and putative biomarker for advancing and chronically established inflammation. Its biological activity across its multiple isoforms plays various roles in the initiation, potent…
View article: Breast and Ovarian Carcinoma Overexpress HLA-G, a Neglected Cancer Immunosuppressive Protein
Breast and Ovarian Carcinoma Overexpress HLA-G, a Neglected Cancer Immunosuppressive Protein Open
Purpose: HLA-G binds to the inhibitory receptors of uterine NK cells and plays an important role in protection of fetal cells from maternal NK lysis. HLA-G also mediates tumor escape, but the immunosuppressive role is often neglected. Thes…
View article: The Pentose Phosphate Pathway Dynamics in Cancer and Its Dependency on Intracellular pH
The Pentose Phosphate Pathway Dynamics in Cancer and Its Dependency on Intracellular pH Open
The Pentose Phosphate Pathway (PPP) is one of the key metabolic pathways occurring in living cells to produce energy and maintain cellular homeostasis. Cancer cells have higher cytoplasmic utilization of glucose (glycolysis), even in the p…
View article: The Interplay of Dysregulated pH and Electrolyte Imbalance in Cancer
The Interplay of Dysregulated pH and Electrolyte Imbalance in Cancer Open
Cancer cells and tissues have an aberrant regulation of hydrogen ion dynamics driven by a combination of poor vascular perfusion, regional hypoxia, and increased the flux of carbons through fermentative glycolysis. This leads to extracellu…
View article: Improving 21<sup>st</sup> Century Cancer Therapy: Correcting Treatment Paradoxes and Combining Integrative and Conventional Oncology
Improving 21<sup>st</sup> Century Cancer Therapy: Correcting Treatment Paradoxes and Combining Integrative and Conventional Oncology Open
Recently there have been many advances in cancer treatment, however, treatment results would be much better if clinical oncologists were educated on the research of cancer metabolism and basic cancer immunology. Many medical oncologists ha…
View article: Neurodegeneration and Mitochondria Organelle Transplantation: “A Technology That Proof of Principle Suggest Is Ready for Prime Time”
Neurodegeneration and Mitochondria Organelle Transplantation: “A Technology That Proof of Principle Suggest Is Ready for Prime Time” Open
It is known that mitochondrial dysfunction is associated with neurodegenerative diseases including amyotrophic lateral sclerosis (ALS). Researchers have tested the therapeutic efficacy of many mitochondrial targeted agents; however, result…
View article: Mitochondria Dynamically Transplant into Cells in Vitro and in Mice and Rescue Aerobic Respiration of Mitochondrial DNA-Depleted Motor Neuron NSC-34
Mitochondria Dynamically Transplant into Cells in Vitro and in Mice and Rescue Aerobic Respiration of Mitochondrial DNA-Depleted Motor Neuron NSC-34 Open
It has been reported that transplantation of pheochromocytoma P12 and hepatoma cells' mitochondria improve the locomotive activity and prevent disease progress in experimental Parkinson's disease rats.To prepare for mitochondrial transplan…
View article: Mitochondrial Toxicity of Azithromycin Results in Aerobic Glycolysis and DNA Damage of Human Mammary Epithelia and Fibroblasts
Mitochondrial Toxicity of Azithromycin Results in Aerobic Glycolysis and DNA Damage of Human Mammary Epithelia and Fibroblasts Open
Mitochondria evolved from free-living bacteria via endocytosis within eukaryotic host cells millions of year ago. We hypothesized that antibiotics cause mammalian mitochondrial damage while causing bacterial lethality. Mitochondrial toxici…
View article: The Role of Sodium Hydrogen Exchanger 1 in Dysregulation of Proton Dynamics and Reprogramming of Cancer Metabolism as a Sequela
The Role of Sodium Hydrogen Exchanger 1 in Dysregulation of Proton Dynamics and Reprogramming of Cancer Metabolism as a Sequela Open
Cancer cells have an unusual regulation of hydrogen ion dynamics that are driven by poor vascularity perfusion, regional hypoxia, and increased glycolysis. All these forces synergize/orchestrate together to create extracellular acidity and…
View article: Abstract 3795: Antibiotics induce mitochondrial dysfunction, DNA damage and aerobic glycolysis of human mammary epithelia and fibroblast
Abstract 3795: Antibiotics induce mitochondrial dysfunction, DNA damage and aerobic glycolysis of human mammary epithelia and fibroblast Open
Mitochondria evolved from free-living bacteria after being endocytosed by eukaryotic host cells millions of year ago. We hypothesized that antibiotics could cause mammalian mitochondrial damage while causing bacterial lethality. Mitochondr…
View article: The adverse effect of gentamicin on cell metabolism in three cultured mammary cell lines: “Are cell culture data skewed?”
The adverse effect of gentamicin on cell metabolism in three cultured mammary cell lines: “Are cell culture data skewed?” Open
Many cells are cultured in media that contains an antibiotic to prevent bacterial contamination. Mycoplasma and other bacterial contamination is a serious problem for those involved in cell culture. Antibiotics in the media helps prevent t…
View article: Antibiotics Induced Mitochondrial Toxicity: “a Neglected Factor Possibly Contributing to Tumorigenesis and Neurodegeneration”
Antibiotics Induced Mitochondrial Toxicity: “a Neglected Factor Possibly Contributing to Tumorigenesis and Neurodegeneration” Open
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View article: Antibiotics Friend and Foe: “From Wonder Drug to Causing Mitochondrial Dysfunction, Disrupting Human Microbiome and Promoting Tumorigenesis”
Antibiotics Friend and Foe: “From Wonder Drug to Causing Mitochondrial Dysfunction, Disrupting Human Microbiome and Promoting Tumorigenesis” Open
Mitochondria are evolutionary bacteria that are dynamic intracellular organelles involved in many vital cellular functions. However, modern medicine has fallen prey to misuse and over-usage of antibiotics. This misuse can damage the mitoch…
View article: Decreased Iron in Cancer Cells and Their Microenvironment Improves Cytolysis of Breast Cancer Cells by Natural Killer Cells
Decreased Iron in Cancer Cells and Their Microenvironment Improves Cytolysis of Breast Cancer Cells by Natural Killer Cells Open
The association of iron with anticancer immunity is unclear. In order to determine the role of iron in anticancer immunity, we manipulated intracellular iron levels of the human MCF-7 and MDA-MB-231 breast cancer cell lines, and measured c…
View article: Initial Experience with Contrast Enhanced Digital Mammography (SenoBright)—In a Comprehensive Clinical Breast Center
Initial Experience with Contrast Enhanced Digital Mammography (SenoBright)—In a Comprehensive Clinical Breast Center Open
Objective: The purpose of initiating contrast enhanced digital mammography in our center was to evaluate the complimentary benefit of this technology with screening digital mammography and real time ultrasound in equivocal cases and high r…
View article: Antibiotic Overusage Causes Mitochondrial Dysfunction Which May Promote Tumorigenesis
Antibiotic Overusage Causes Mitochondrial Dysfunction Which May Promote Tumorigenesis Open
Mitochondria are dynamic intracellular organelles involved in many vital cellular functions. It is important to maintain good mitochondrial biogenesis and health. Mitochondrial dysfunction is known to be associated with many neurodegenerat…
View article: Cancer Immunotherapy "HLA-G an Important Neglected Immunosuppressive Molecule"
Cancer Immunotherapy "HLA-G an Important Neglected Immunosuppressive Molecule" Open
CD8+ T-cell destruction.Though much has been published about HLA-G as a cancer immunosuppressant molecule, little has been done to attack HLA-G as a cancer therapeutic target.In this review, we hope to stimulate researchers to investigate …
View article: Mitochondria and Neurodegeneration "Could Mitochondrial Organelle Transfer be a Cellular Biotherapy for Neurodegenerative Diseases?"
Mitochondria and Neurodegeneration "Could Mitochondrial Organelle Transfer be a Cellular Biotherapy for Neurodegenerative Diseases?" Open
It has been known for some time the abnormal function of mitochondria is associated with neurodegenerative diseases. Mitochondrial dysfunction has been implicated in the pathogenesis of Parkinson', Alzheimer's, amyotrophic lateral sclerosi…
View article: Mitochondria Organelle Transplantation: “A Potential Cellular Biotherapy for Cancer”
Mitochondria Organelle Transplantation: “A Potential Cellular Biotherapy for Cancer” Open
Mitochondrial dysfunction is implicated in many human diseases including metabolic, ageing, cancer, cardiovascular and neurodegenerative.In the 1930's Warburg demonstrated that defective mitochondrial respiration altered tumor cell metabol…