Robert L. Ullrich
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View article: Causal Machine Learning Analysis of All-Cause Mortality in Japanese Atomic-Bomb Survivors
Causal Machine Learning Analysis of All-Cause Mortality in Japanese Atomic-Bomb Survivors Open
The health consequences of ionizing radiation have long been studied, yet significant uncertainties remain, particularly at low doses. In particular, traditional dose-response models such as linear, linear-quadratic, threshold, or hormesis…
View article: Causal Machine Learning Analysis of Radiation-Induced Leukemia and Solid Tumor Incidence in Japanese Atomic Bomb Survivors
Causal Machine Learning Analysis of Radiation-Induced Leukemia and Solid Tumor Incidence in Japanese Atomic Bomb Survivors Open
Uncertainty in low-dose ionizing radiation-induced health risks stems from several factors. The complex biological pathways leading to diseases like cancer are not fully understood, making it difficult to distinguish the contribution of ra…
View article: Novel Insights for Radiation Risk Assessment Unveiled by Deep Learning
Novel Insights for Radiation Risk Assessment Unveiled by Deep Learning Open
Contemporary radiation risk assessment predominantly depends on nonlinear parametric models, which typically include a baseline term, a dose-response term, and an effect modifier term. Despite their widespread application in estimating tum…
View article: Data from Telomere Dysfunction and DNA-PKcs Deficiency: Characterization and Consequence
Data from Telomere Dysfunction and DNA-PKcs Deficiency: Characterization and Consequence Open
The mechanisms by which cells accurately distinguish between DNA double-strand break (DSB) ends and telomeric DNA ends remain poorly defined. Recent investigations have revealed intriguing interactions between DNA repair and telomeres. We …
View article: Supplementary Table 1 from Telomere Dysfunction and DNA-PKcs Deficiency: Characterization and Consequence
Supplementary Table 1 from Telomere Dysfunction and DNA-PKcs Deficiency: Characterization and Consequence Open
Supplementary Table 1 from Telomere Dysfunction and DNA-PKcs Deficiency: Characterization and Consequence
View article: Supplementary Table 1 from Telomere Dysfunction and DNA-PKcs Deficiency: Characterization and Consequence
Supplementary Table 1 from Telomere Dysfunction and DNA-PKcs Deficiency: Characterization and Consequence Open
Supplementary Table 1 from Telomere Dysfunction and DNA-PKcs Deficiency: Characterization and Consequence
View article: Supplementary Table 2 from Telomere Dysfunction and DNA-PKcs Deficiency: Characterization and Consequence
Supplementary Table 2 from Telomere Dysfunction and DNA-PKcs Deficiency: Characterization and Consequence Open
Supplementary Table 2 from Telomere Dysfunction and DNA-PKcs Deficiency: Characterization and Consequence
View article: Data from Telomere Dysfunction and DNA-PKcs Deficiency: Characterization and Consequence
Data from Telomere Dysfunction and DNA-PKcs Deficiency: Characterization and Consequence Open
The mechanisms by which cells accurately distinguish between DNA double-strand break (DSB) ends and telomeric DNA ends remain poorly defined. Recent investigations have revealed intriguing interactions between DNA repair and telomeres. We …
View article: Supplementary Table 2 from Telomere Dysfunction and DNA-PKcs Deficiency: Characterization and Consequence
Supplementary Table 2 from Telomere Dysfunction and DNA-PKcs Deficiency: Characterization and Consequence Open
Supplementary Table 2 from Telomere Dysfunction and DNA-PKcs Deficiency: Characterization and Consequence
View article: Orthologs of human circulating miRNAs associated with hepatocellular carcinoma are elevated in mouse plasma months before tumour detection
Orthologs of human circulating miRNAs associated with hepatocellular carcinoma are elevated in mouse plasma months before tumour detection Open
Research examining the potential for circulating miRNA to serve as markers for preneoplastic lesions or early-stage hepatocellular carcinoma (HCC) is hindered by the difficulties of obtaining samples from asymptomatic individuals. As a sur…
View article: Orthologs of Human Circulating miRNAs Associated with Hepatocellular Carcinoma Are Elevated in Mouse Plasma Months before Tumour Detection
Orthologs of Human Circulating miRNAs Associated with Hepatocellular Carcinoma Are Elevated in Mouse Plasma Months before Tumour Detection Open
Research examining the potential for circulating miRNA as serve as markers for preneoplastic lesions or early-stage hepatocellular carcinoma (HCC) is hindered by the difficulties of obtaining samples from asymptomatic individuals. As a sur…
View article: Mitochondrial Effects in the Liver of C57BL/6 Mice by Low Dose, High Energy, High Charge Irradiation
Mitochondrial Effects in the Liver of C57BL/6 Mice by Low Dose, High Energy, High Charge Irradiation Open
Galactic cosmic rays are primarily composed of protons (85%), helium (14%), and high charge/high energy ions (HZEs) such as 56Fe, 28Si, and 16O. HZE exposure is a major risk factor for astronauts during deep-space travel due to the possibi…
View article: Transcriptomic analysis links hepatocellular carcinoma (HCC) in HZE ion irradiated mice to a human HCC subtype with favorable outcomes
Transcriptomic analysis links hepatocellular carcinoma (HCC) in HZE ion irradiated mice to a human HCC subtype with favorable outcomes Open
High-charge, high-energy ion particle (HZE) radiations are extraterrestrial in origin and characterized by high linear energy transfer (high-LET), which causes more severe cell damage than low-LET radiations like γ-rays or photons. High-LE…
View article: Effects of Low Dose Space Radiation Exposures on the Splenic Metabolome
Effects of Low Dose Space Radiation Exposures on the Splenic Metabolome Open
Future space missions will include a return to the Moon and long duration deep space roundtrip missions to Mars. Leaving the protection that Low Earth Orbit provides will unavoidably expose astronauts to higher cumulative doses of space ra…
View article: <sup>137</sup>Cs γ Ray and <sup>28</sup>Si Irradiation Induced Murine Hepatocellular Carcinoma Lipid Changes in Liver Assessed by MALDI-MSI Combined with Spatial Shrunken Centroid Clustering Algorithm: A Pilot Study
<sup>137</sup>Cs γ Ray and <sup>28</sup>Si Irradiation Induced Murine Hepatocellular Carcinoma Lipid Changes in Liver Assessed by MALDI-MSI Combined with Spatial Shrunken Centroid Clustering Algorithm: A Pilot Study Open
Characterization of lipids by matrix-assisted laser desorption ionization mass spectrometry imaging (MALDI-MSI) is of great interest because not only are lipids important structural molecules in both the cell and internal organelle membran…
View article: Comparative RNA-Seq transcriptome analyses reveal dynamic time-dependent effects of 56Fe, 16O, and 28Si irradiation on the induction of murine hepatocellular carcinoma
Comparative RNA-Seq transcriptome analyses reveal dynamic time-dependent effects of 56Fe, 16O, and 28Si irradiation on the induction of murine hepatocellular carcinoma Open
View article: Efficient identification of multiple pathways: RNA-Seq analysis of livers from 56Fe ion irradiated mice
Efficient identification of multiple pathways: RNA-Seq analysis of livers from 56Fe ion irradiated mice Open
View article: Comparative RNA-Seq transcriptome analyses reveal dynamic time-dependent effects of 56Fe, 16O, and 28Si irradiation on the induction of murine hepatocellular carcinoma
Comparative RNA-Seq transcriptome analyses reveal dynamic time-dependent effects of 56Fe, 16O, and 28Si irradiation on the induction of murine hepatocellular carcinoma Open
Background: One of the health risks posed to astronauts during deep space flights is exposure to high charge, high-energy (HZE) ions (Z>13), which can lead to induction of hepatocellular carcinoma (HCC). However, little is known on the mol…
View article: Additional file 1 of Efficient identification of multiple pathways: RNA-Seq analysis of livers from 56Fe ion irradiated mice
Additional file 1 of Efficient identification of multiple pathways: RNA-Seq analysis of livers from 56Fe ion irradiated mice Open
Additional file 1: Supplementary Table 1. Gene cluster-assignment comparison. Complete list of gene cluster-assignments using Recursive Indirect-Paths Modularity (RIP-M), Weighted Gene Co-Expression Network Analysis (WGCNA), and Weighted G…
View article: PS1317 VITAMIN D3 INHIBITS GROWTH OF HODGKIN CELL LINES AND IMPROVES SENSITIVITY TO CHEMOTHERAPY AT PHYSIOLOGICAL DOSES IN VITRO AND IN VIVO
PS1317 VITAMIN D3 INHIBITS GROWTH OF HODGKIN CELL LINES AND IMPROVES SENSITIVITY TO CHEMOTHERAPY AT PHYSIOLOGICAL DOSES IN VITRO AND IN VIVO Open
Background: Compared with healthy B-cells, lymphoma cells commonly present with increased rate of protein synthesis and of glycolysis. 2-Deoxyglucose (2-DG), an inhibitor of the key enzyme of glycolysis, irreversibly blocks glucose metabol…
View article: Novel regenerative peptide TP508 mitigates radiation-induced gastrointestinal damage by activating stem cells and preserving crypt integrity
Novel regenerative peptide TP508 mitigates radiation-induced gastrointestinal damage by activating stem cells and preserving crypt integrity Open
View article: Comments on Estimating Risks of Low Radiation Doses—A Critical Review of the BEIR VII Report and Its Use of the Linear No-Threshold (LNT) Hypothesis by Edward J. Calabrese and Michael K. O'Connor
Comments on Estimating Risks of Low Radiation Doses—A Critical Review of the BEIR VII Report and Its Use of the Linear No-Threshold (LNT) Hypothesis by Edward J. Calabrese and Michael K. O'Connor Open
NAS') Biological Effects of Ionizing Radiation VII (BEIR VII) report (2).We write to correct several mischaracterizations and inaccuracies in their commentary.Our comments are organized according to the sections in C&O's article. LNT MODEL…