Robert Lakin
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View article: The Role of Lysyl Oxidase-Like 2 in Atrial Fibrillation Induced by Aortic Regurgitation
The Role of Lysyl Oxidase-Like 2 in Atrial Fibrillation Induced by Aortic Regurgitation Open
View article: The effects of daily dose of intense exercise on cardiac responses and atrial fibrillation
The effects of daily dose of intense exercise on cardiac responses and atrial fibrillation Open
Atrial fibrillation (AF) is a supraventricular tachyarrhythmia that is strongly associated with cardiovascular (CV) disease and sedentary lifestyles. Despite the benefits of exercise on overall health, AF incidence in high‐level endurance …
View article: Cardiomyocyte and endothelial cells play distinct roles in the tumour necrosis factor (TNF)-dependent atrial responses and increased atrial fibrillation vulnerability induced by endurance exercise training in mice
Cardiomyocyte and endothelial cells play distinct roles in the tumour necrosis factor (TNF)-dependent atrial responses and increased atrial fibrillation vulnerability induced by endurance exercise training in mice Open
Aims Endurance exercise is associated with an increased risk of atrial fibrillation (AF). We previously established that adverse atrial remodelling and AF susceptibility induced by intense exercise in mice require the mechanosensitive and …
View article: Proteomics and phosphoproteomics of failing human left ventricle identifies dilated cardiomyopathy-associated phosphorylation of CTNNA3
Proteomics and phosphoproteomics of failing human left ventricle identifies dilated cardiomyopathy-associated phosphorylation of CTNNA3 Open
The prognosis and treatment outcomes of heart failure (HF) patients rely heavily on disease etiology, yet the majority of underlying signaling mechanisms are complex and not fully elucidated. Phosphorylation is a major point of protein reg…
View article: Tmem65 is critical for the structure and function of the intercalated discs in mouse hearts
Tmem65 is critical for the structure and function of the intercalated discs in mouse hearts Open
View article: Dissecting the Roles of the Autonomic Nervous System and Physical Activity on Circadian Heart Rate Fluctuations in Mice
Dissecting the Roles of the Autonomic Nervous System and Physical Activity on Circadian Heart Rate Fluctuations in Mice Open
Heart rate (HR) and blood pressure as well as adverse cardiovascular events show clear circadian patterns, which are linked to interdependent daily variations in physical activity and cardiac autonomic nerve system (ANS) activity. We set o…
View article: Intensity-Based Computation Tomography (CT) Evaluation of Temporal Changes in Lung Abnormalities During the Recovery Stage in COVID-19 In-Hospital Patients
Intensity-Based Computation Tomography (CT) Evaluation of Temporal Changes in Lung Abnormalities During the Recovery Stage in COVID-19 In-Hospital Patients Open
Background: The coronavirus disease-19 (COVID-19) and its variants have increased rapidly worldwide since December 2019, with respiratory disease being a prominent complication. As such, optimizing evaluation methods and identifying factor…
View article: Too sympathetic to exercise: abnormal autonomic and metaboreflex activation in exercising rheumatoid arthritis patients
Too sympathetic to exercise: abnormal autonomic and metaboreflex activation in exercising rheumatoid arthritis patients Open
Rheumatoid arthritis (RA) is a systemic autoimmune rheumatic disease characterized by chronic inflammation and eventual degradation of synovium in the extremities, causing deterioration to the surrounding cartilage and bone (Avina-Zubieta …
View article: Computation Tomography (CT)-Based Evaluation of Temporal Changes in Lung Abnormalities During the Recovery Stage in COVID-19 In-Hospital Patients
Computation Tomography (CT)-Based Evaluation of Temporal Changes in Lung Abnormalities During the Recovery Stage in COVID-19 In-Hospital Patients Open
Objectives: To assess the late phase CT changes of COVID-19 patients, and figure out factors predicting lung abnormality in late phase. Methods: We conducted a retrospective study on 42 patients (14 males, 28 females; age 65±10 years) with…
View article: Transcriptomic Bioinformatic Analyses of Atria Uncover Involvement of Pathways Related to Strain and Post-translational Modification of Collagen in Increased Atrial Fibrillation Vulnerability in Intensely Exercised Mice
Transcriptomic Bioinformatic Analyses of Atria Uncover Involvement of Pathways Related to Strain and Post-translational Modification of Collagen in Increased Atrial Fibrillation Vulnerability in Intensely Exercised Mice Open
Atrial Fibrillation (AF) is the most common supraventricular tachyarrhythmia that is typically associated with cardiovascular disease (CVD) and poor cardiovascular health. Paradoxically, endurance athletes are also at risk for AF. While it…
View article: Apelin increases atrial conduction velocity, refractoriness, and prevents inducibility of atrial fibrillation
Apelin increases atrial conduction velocity, refractoriness, and prevents inducibility of atrial fibrillation Open
Previous studies have shown an association between elevated atrial NADPH-dependent oxidative stress and decreased plasma apelin in patients with atrial fibrillation (AF), though the basis for this relationship is unclear. In the current st…
View article: Revisiting right anterior oblique projections for the triangle of Koch: implications from computed tomography
Revisiting right anterior oblique projections for the triangle of Koch: implications from computed tomography Open
View article: Mid‐life crisis or mid‐life gains: 2 years of high‐intensity exercise is highly beneficial for the middle‐aged heart
Mid‐life crisis or mid‐life gains: 2 years of high‐intensity exercise is highly beneficial for the middle‐aged heart Open
High-intensity exercise has long been shown to induce beneficial adaptations of the cardiovascular (CV) system, including reducing heart rate (HR) and its regulation by the autonomic nervous system. A number of parameters are typically emp…
View article: Dabigatran as an alternative for atrial thrombosis resistant to rivaroxaban
Dabigatran as an alternative for atrial thrombosis resistant to rivaroxaban Open
Rationale: Anti-thrombosis therapy for atrial fibrillation (AF) management and stroke prevention is an important aspect of disease management. Novel oral anticoagulants (NOACs) are recommended by guidelines for AF management. However, if o…
View article: Changes in Heart Rate and Its Regulation by the Autonomic Nervous System Do Not Differ Between Forced and Voluntary Exercise in Mice
Changes in Heart Rate and Its Regulation by the Autonomic Nervous System Do Not Differ Between Forced and Voluntary Exercise in Mice Open
-No previous mouse studies have compared the effects of forced and voluntary exercise on the heart function and its modulation by the autonomic nervous system (ANS).-Both voluntary free-wheel running and forced swimming induced similar imp…
View article: Daily 10 mg rivaroxaban as a therapy for ventricular thrombus related to left ventricular non-compaction cardiomyopathy
Daily 10 mg rivaroxaban as a therapy for ventricular thrombus related to left ventricular non-compaction cardiomyopathy Open
Low dose of rivaroxaban may serve as a viable option for anticoagulation therapy in LVNC patients, with large clinical trials needed to determine the best course of treatment.
View article: Kept in the loop: longitudinal strain–volume relationships for the assessment of left ventricular mechanical performance
Kept in the loop: longitudinal strain–volume relationships for the assessment of left ventricular mechanical performance Open
In health, the aortic valve facilitates unidirectional forward flow from the left ventricle (LV) to the systemic circulation. During systole, the valve offers little impedance to LV outflow, while during diastole, it prevents regurgitant b…
View article: Letter by Sun et al Regarding Article, “Electrogram Analysis and Pacing Are Complimentary for Recognition of Abnormal Conduction and Far-Field Potentials During Substrate Mapping of Infarct-Related Ventricular Tachycardia”
Letter by Sun et al Regarding Article, “Electrogram Analysis and Pacing Are Complimentary for Recognition of Abnormal Conduction and Far-Field Potentials During Substrate Mapping of Infarct-Related Ventricular Tachycardia” Open
View article: Characterizing fast pathway in typical and atypical atrioventricular nodal re-entrant tachycardia by atrial-His and His-atrial: more to consider
Characterizing fast pathway in typical and atypical atrioventricular nodal re-entrant tachycardia by atrial-His and His-atrial: more to consider Open
We read with interest the paper by Katritsis et al. 1 published in Europace recently. In this study, the authors sought to assess the prevalence, electrophysiological characteristics, and mechanism underlying atypical atrioventricular noda…
View article: Nature <i>versus</i> exposure: matched exposure to circulatory stressors of different natures elicits adaptive remodelling
Nature <i>versus</i> exposure: matched exposure to circulatory stressors of different natures elicits adaptive remodelling Open
The systemic circulation consists of a pulsatile pump that delivers blood into a proximal vascular capacitor, subsequently distributing blood to the periphery with minimal variation in flow and pressure. In the face of chronic workload ele…
View article: Interpretation of discrete potential in idiopathic outflow tract ventricular arrhythmia: more consideration
Interpretation of discrete potential in idiopathic outflow tract ventricular arrhythmia: more consideration Open
We read with interest the article by Liu et al. 1 published recently in EP-Europace . In this article, the authors showed that discrete potentials (DPs) appeared to be a prerequisite for idiopathic outflow tract premature ventricular contr…