Shawn R. Lockhart
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View article: <i>Candida auris</i> colonization among critically ill neonatal intensive care unit patients in Dhaka, Bangladesh
<i>Candida auris</i> colonization among critically ill neonatal intensive care unit patients in Dhaka, Bangladesh Open
Candida auris is a multidrug-resistant yeast causing invasive infection and healthcare-associated outbreaks globally. We aimed to estimate the extent of C. auris colonization and infection among neonates in selected neonatal intensive care…
View article: Chromoblastomycosis and phaeohyphomycotic abscess-associated hospitalizations, United States, 2016–2021
Chromoblastomycosis and phaeohyphomycotic abscess-associated hospitalizations, United States, 2016–2021 Open
Background Chromoblastomycosis and phaeohyphomycotic abscesses are infections of the skin and subcutaneous tissues caused by dematiaceous fungi; more rarely, phaeohyphomycotic brain abscesses can occur. The epidemiology and clinical outcom…
View article: Global Emergence of Antifungal‐Resistant Dermatophytosis Caused by <i>Trichophyton indotineae</i> (Formerly <i>T. mentagrophytes</i><scp>ITS</scp> Genotype <scp>VIII</scp>): A Genomic Investigation Involving 14 Countries
Global Emergence of Antifungal‐Resistant Dermatophytosis Caused by <i>Trichophyton indotineae</i> (Formerly <i>T. mentagrophytes</i><span>ITS</span> Genotype <span>VIII</span>): A Genomic Investigation Involving 14 Countries Open
Background and Objective Trichophyton indotineae is a globally emerging, frequently antifungal‐resistant fungus causing severe dermatophytosis. To inform prevention efforts, we analysed the genomic epidemiology and resistance to terbinafin…
View article: A benchmark dataset for validating <i>FKS1</i> mutations in <i>Candida auris</i>
A benchmark dataset for validating <i>FKS1</i> mutations in <i>Candida auris</i> Open
Echinocandins are the recommended antifungal therapy for Candida auris infections in many countries. While echinocandin resistance remains uncommon, recent reports demonstrate an increase in such cases, with the potential for echinocandin-…
View article: Population-Based Active Surveillance for Culture-Confirmed Candidemia — 10 Sites, United States, 2017–2021
Population-Based Active Surveillance for Culture-Confirmed Candidemia — 10 Sites, United States, 2017–2021 Open
Strict implementation of measures to prevent health care-associated bloodstream infections is important to help prevent candidemia cases. Health care officials and providers should be vigilant for candidemia as a complication of critical i…
View article: Establishment of epidemiological cutoff values for <i>Fonsecaea pedrosoi</i> , the primary etiologic agent of chromoblastomycosis, and eight antifungal medications
Establishment of epidemiological cutoff values for <i>Fonsecaea pedrosoi</i> , the primary etiologic agent of chromoblastomycosis, and eight antifungal medications Open
Chromoblastomycosis, a fungal neglected tropical disease, is acquired through traumatic inoculation and is clinically characterized by a chronic granulomatous infection of the skin and subcutaneous tissue. Fonsecaea pedrosoi is the most co…
View article: Epidemiological Study of Cryptococcus gattii Complex Infection in Domestic and Wild Animals in Oregon
Epidemiological Study of Cryptococcus gattii Complex Infection in Domestic and Wild Animals in Oregon Open
The members of the Cryptococcus gattii species complex are the etiologic agents of potentially fatal human infection. C. gattii causes disease in both immunocompetent and immunocompromised hosts. In the early 2000s, infection caused by C. …
View article: Predictors of <i>Cryptococcus gattii</i> Clinical Presentation and Outcome: An International Study
Predictors of <i>Cryptococcus gattii</i> Clinical Presentation and Outcome: An International Study Open
Background Infection by Cryptococcus gattii can lead to pulmonary or central nervous system (CNS) disease, or both. Whether the sites of infection and disease severity are associated with C. gattii species and lineages or with certain unde…
View article: Nomenclature for human and animal fungal pathogens and diseases: a proposal for standardized terminology
Nomenclature for human and animal fungal pathogens and diseases: a proposal for standardized terminology Open
Medically important pathogenic fungi invade vertebrate tissue and are considered primary when part of their nature life cycle is associated with an animal host and are usually able to infect immunocompetent hosts. Opportunistic fungal path…
View article: Epidemiological and Clinical Features of a Large Blastomycosis Outbreak at a Paper Mill in Michigan
Epidemiological and Clinical Features of a Large Blastomycosis Outbreak at a Paper Mill in Michigan Open
Background Blastomycosis is an environmentally acquired fungal infection that can result in severe pulmonary illness and high hospitalization rates. In 2023, a blastomycosis outbreak was detected among workers at a paper mill in Delta Coun…
View article: A global chromoblastomycosis strategy and development of the global chromoblastomycosis working group
A global chromoblastomycosis strategy and development of the global chromoblastomycosis working group Open
Chromoblastomycosis, an implantation mycosis, is a neglected tropical disease that causes decreased quality of life, stigma, and disability. The global burden of disease is unknown and data on disease epidemiology and outcomes are severely…
View article: Geographical distribution of the Cryptococcus gattii species complex: a systematic review
Geographical distribution of the Cryptococcus gattii species complex: a systematic review Open
The taxonomy of the Cryptococcus gattii species complex continues to evolve, and has been divided into five pathogenic species. The objective of this systematic review was to summarise the geographical distribution of the C gattii species …
View article: Recognition of Antifungal-Resistant Dermatophytosis by Infectious Diseases Specialists, United States
Recognition of Antifungal-Resistant Dermatophytosis by Infectious Diseases Specialists, United States Open
Antifungal-resistant dermatophyte infections have recently emerged as a global public health concern. A survey of US infectious diseases specialists found that only 65% had heard of this issue and just 39% knew how to obtain testing to det…
View article: Testing for Blastomycosis, Coccidioidomycosis, and Histoplasmosis at a Major Commercial Laboratory, United States, 2019–2024
Testing for Blastomycosis, Coccidioidomycosis, and Histoplasmosis at a Major Commercial Laboratory, United States, 2019–2024 Open
Background Blastomycosis, coccidioidomycosis, and histoplasmosis are environmentally acquired fungal diseases that clinically resemble bacterial and viral community-acquired pneumonia and require laboratory testing for diagnosis. Patients …
View article: Erratum for Misas et al., “Genomic description of acquired fluconazole- and echinocandin-resistance in patients with serial <i>Candida glabrata</i> isolates”
Erratum for Misas et al., “Genomic description of acquired fluconazole- and echinocandin-resistance in patients with serial <i>Candida glabrata</i> isolates” Open
Volume 62, no. 2, e01140-23, https://doi.org/10.1128/jcm.01140-23. In the abstract, "Of the 24 fluconazole-resistant isolates, 17 (71%) had non-synonymous polymorphisms" should read "Of the 25 fluconazole-resistant isolates, 16 (64%) had n…
View article: Clinical Course, Antifungal Susceptibility, and Genomic Sequencing of <i>Trichophyton indotineae</i>
Clinical Course, Antifungal Susceptibility, and Genomic Sequencing of <i>Trichophyton indotineae</i> Open
Importance Trichophyton indotineae is an emerging dermatophyte causing outbreaks of extensive tinea infections often unresponsive to terbinafine. This species has been detected worldwide and in multiple US states, yet detailed US data on i…
View article: Molecular and Epidemiological Investigation of Fluconazole-resistant <i>Candida parapsilosis</i>—Georgia, United States, 2021
Molecular and Epidemiological Investigation of Fluconazole-resistant <i>Candida parapsilosis</i>—Georgia, United States, 2021 Open
Background Reports of fluconazole-resistant Candida parapsilosis bloodstream infections are increasing. We describe a cluster of fluconazole-resistant C parapsilosis bloodstream infections identified in 2021 on routine surveillance by the …
View article: Sporotrichosis Cluster in Domestic Cats and Veterinary Technician, Kansas, USA, 2022
Sporotrichosis Cluster in Domestic Cats and Veterinary Technician, Kansas, USA, 2022 Open
We describe a feline sporotrichosis cluster and zoonotic transmission between one of the affected cats and a technician at a veterinary clinic in Kansas, USA. Increased awareness of sporotrichosis and the potential for zoonotic transmissio…
View article: Potential Sexual Transmission of Antifungal-Resistant <i>Trichophyton indotineae</i>
Potential Sexual Transmission of Antifungal-Resistant <i>Trichophyton indotineae</i> Open
We describe a case of tinea genitalis in an immunocompetent woman in Pennsylvania, USA. Infection was caused by Trichophyton indotineae potentially acquired through sexual contact. The fungus was resistant to terbinafine (first-line antifu…
View article: Reply to Kidd et al., “Inconsistencies within the proposed framework for stabilizing fungal nomenclature risk further confusion”
Reply to Kidd et al., “Inconsistencies within the proposed framework for stabilizing fungal nomenclature risk further confusion” Open
International audience
View article: Emergence of zoonotic sporotrichosis in Brazil: a genomic epidemiology study
Emergence of zoonotic sporotrichosis in Brazil: a genomic epidemiology study Open
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, Brazil; the São Paulo Research Foundation; Productivity in Research fellowships by the National Council for Scientific and Technological Development, and Ministry of Science and …
View article: Bimodal distribution of azole susceptibility in <i>Sporothrix brasiliensis</i> isolates in Brazil
Bimodal distribution of azole susceptibility in <i>Sporothrix brasiliensis</i> isolates in Brazil Open
Sporothrix brasiliensis is an emerging zoonotic fungal pathogen that can be difficult to treat. Antifungal susceptibility testing was performed on the mold phase of a convenience sample of 61 Sporothrix spp. isolates from human and cat spo…
View article: Evaluation of CHROMagar <i>Candida</i> Plus for the detection of <i>C. auris</i> with a panel of 206 fungal isolates and 83 colonization screening skin-swabs
Evaluation of CHROMagar <i>Candida</i> Plus for the detection of <i>C. auris</i> with a panel of 206 fungal isolates and 83 colonization screening skin-swabs Open
CHROMagar Candida Plus is a new formulation of chromogenic media designed for the detection and differentiation of major clinical Candida species, including Candida auris . The objective of this study is to evaluate CHROMagar Candida Plus …
View article: Genomic description of acquired fluconazole- and echinocandin-resistance in patients with serial <i>Candida glabrata</i> isolates
Genomic description of acquired fluconazole- and echinocandin-resistance in patients with serial <i>Candida glabrata</i> isolates Open
In our study, mutations associated to azole resistance and echinocandin resistance were detected in Candida glabrata isolates using a whole-genome sequence. C. glabrata is the second most common cause of candidemia in the United States, wh…
View article: <i>Trichophyton indotineae</i> and other terbinafine-resistant dermatophytes in North America
<i>Trichophyton indotineae</i> and other terbinafine-resistant dermatophytes in North America Open
Dermatophyte infections (a.k.a. ringworm, tinea) affect an estimated 20%–25% of the world’s population. In North America, most dermatophytoses are caused by Trichophyton rubrum or Trichophyton mentagrophytes species complexes. Severe and a…
View article: 619. Fungal Species Causing Eumycetoma and Chromoblastomycosis in a Commercial Laboratory, United States
619. Fungal Species Causing Eumycetoma and Chromoblastomycosis in a Commercial Laboratory, United States Open
Background The World Health Organization (WHO) designates the implantation mycoses eumycetoma and chromoblastomycosis as Neglected Tropical Diseases. These infections usually develop after traumatic skin inoculation and primarily occur in …