Robert M. Edkins
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View article: Comparing microscopic and macroscopic diffusion in drug delivery: A study of small drug and protein dynamics in a supramolecular peptide hydrogel
Comparing microscopic and macroscopic diffusion in drug delivery: A study of small drug and protein dynamics in a supramolecular peptide hydrogel Open
Over recent decades, medicine development has increasingly turned to biologics for their higher efficacy and reduced side effects compared to small molecule drugs. However, the necessity for parenteral administration of these labile compou…
View article: Perturbation of water–ethanol solvent structural relaxation by a bis-urea supramolecular gel and paracetamol
Perturbation of water–ethanol solvent structural relaxation by a bis-urea supramolecular gel and paracetamol Open
Understanding structural dynamics on the picosecond/nanometer scale in complex fluids is crucial for advancing various fields, from material chemistry to drug delivery. We employ polarized quasi-elastic neutron spectroscopy to investigate …
View article: Monitoring Radical Intermediates in Photoactivated Palladium-Catalyzed Coupling of Aryl Halides to Arenes by an Aryl Radical Assay
Monitoring Radical Intermediates in Photoactivated Palladium-Catalyzed Coupling of Aryl Halides to Arenes by an Aryl Radical Assay Open
An aryl radical assay is used to provide information about the formation of aryl radicals from aryl halides in coupling reactions to arenes in the presence of palladium sources and under LED irradiation (λ = 456 nm). The assay uses 2-halo-…
View article: Role of Secondary Structure and Time‐Dependent Binding on Disruption of Phthalocyanine Aggregates by Guanine‐Rich Nucleic Acids
Role of Secondary Structure and Time‐Dependent Binding on Disruption of Phthalocyanine Aggregates by Guanine‐Rich Nucleic Acids Open
Phthalocyanines are versatile photodynamic therapy agents whose biological activity depends on their aggregation state, which is expected to be influenced by binding to biomolecules. Here, guanine‐rich nucleic acid binding of a water‐solub…
View article: Monitoring Radical Intermediates in Photoactivated Palladium-Catalysed Coupling of Aryl Halides to Arenes by an Aryl Radical Assay
Monitoring Radical Intermediates in Photoactivated Palladium-Catalysed Coupling of Aryl Halides to Arenes by an Aryl Radical Assay Open
An aryl radical assay is used to provide information about the formation of aryl radicals from aryl halides in coupling reactions to arenes in the presence of palladium sources and under LED irradiation (lambda = 456 nm). The assay uses 2-…
View article: Molecular structural dynamics in water–ethanol mixtures: Spectroscopy with polarized neutrons simultaneously accessing collective and self-diffusion
Molecular structural dynamics in water–ethanol mixtures: Spectroscopy with polarized neutrons simultaneously accessing collective and self-diffusion Open
Binary mixtures of water with lower alcohols display non-linear phase behaviors upon mixing, which are attributed to potential cluster formation at the molecular level. Unravelling such elusive structures requires investigation of hydrogen…
View article: Elucidating the hydrotropism behaviour of aqueous caffeine and sodium benzoate solution through NMR and neutron total scattering analysis
Elucidating the hydrotropism behaviour of aqueous caffeine and sodium benzoate solution through NMR and neutron total scattering analysis Open
Hydrotropism is a convenient way to increase the solubility of drugs by up to several orders of magnitude, and even though it has been researched for decades with both experimental and simulation methods, its mechanism is still unknown. He…
View article: Molecular Structural Dynamics in Water-Ethanol Mixtures: Spectroscopy with Polarized Neutrons Simultaneously Accessing Collective and Self-Diffusion
Molecular Structural Dynamics in Water-Ethanol Mixtures: Spectroscopy with Polarized Neutrons Simultaneously Accessing Collective and Self-Diffusion Open
Binary mixtures of water with lower alcohols display non-linear phase behaviour upon mixing which are attributed to potential cluster formation at molecular level. Unravelling such elusive structures requires the investigation of hydrogen-…
View article: Synthesis of Multifunctional C4h Octa-substituted Phthalocyanines
Synthesis of Multifunctional C4h Octa-substituted Phthalocyanines Open
The selective synthesis of multiply functionalized phthalocyanines (Pcs) as single regioisomers remains challenging. We report our approach for the selective synthesis of C4h Pcs bearing different α- and β-substituents. These C4h phthalocy…
View article: CCDC 2169136: Experimental Crystal Structure Determination
CCDC 2169136: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Divergent Approach for <i>Tris</i>-Heteroleptic Cyclometalated Iridium Complexes Using Triisopropylsilylethynyl-Substituted Synthons
Divergent Approach for <i>Tris</i>-Heteroleptic Cyclometalated Iridium Complexes Using Triisopropylsilylethynyl-Substituted Synthons Open
Bis-heteroleptic cyclometalated iridium complexes of the form Ir(La)2(acac), where La is a substituted 2-phenylpyridine derivative and acac is an acetylacetonato ligand, are a useful class of luminescent organometallic complexes for a rang…
View article: Targeted Cancer Phototherapy Using Phthalocyanine–Anticancer Drug Conjugates
Targeted Cancer Phototherapy Using Phthalocyanine–Anticancer Drug Conjugates Open
Phototherapy, the use of light to selectively ablate cancerous tissue, is a compelling prospect. Phototherapy is divided into two major domains: photodynamic and photothermal, whereby photosensitizer irradiation generates reactive oxygen s…
View article: Targeted cancer phototherapy using phthalocyanine–anticancer drug conjugates
Targeted cancer phototherapy using phthalocyanine–anticancer drug conjugates Open
The strategy of targeting phthalocyanine photosensitizers by conjugation to different classes of anticancer drugs for improved phototherapy is reviewed.