Robert M. Gill
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View article: Genomic heterozygosity is associated with a lower risk of osteoarthritis
Genomic heterozygosity is associated with a lower risk of osteoarthritis Open
Background Genomic heterozygosity has been shown to confer a health advantage in humans and play a protective role in complex diseases. Given osteoarthritis (OA) is a highly polygenic disease, we set out to determine if an association exis…
View article: Epidemiological factors associated with revision of total joint replacement surgery: A nested case-control study
Epidemiological factors associated with revision of total joint replacement surgery: A nested case-control study Open
Background: Total Joint Replacement (TJR) is the most effective treatment for patients with end-stage joint pathologies, such as osteoarthritis (OA). However, this procedure can result in prosthesis failure, consequently requiring an early…
View article: The role of Glutaredoxin-2 in the modulation of mitochondrial bioenergetics in female mice fed a high-fat diet
The role of Glutaredoxin-2 in the modulation of mitochondrial bioenergetics in female mice fed a high-fat diet Open
Our group recently observed that male mice containing a deletion for the gene encoding the thiol oxidoreductase glutaredoxin-2 (GRX2) were protected from diet-induced obesity (DIO) and the development of related disorders (e.g. fatty liver…
View article: An investigation into the impact of deleting one copy of the <i>glutaredoxin-2</i> gene on diet-induced weight gain and the bioenergetics of muscle mitochondria in female mice fed a high fat diet
An investigation into the impact of deleting one copy of the <i>glutaredoxin-2</i> gene on diet-induced weight gain and the bioenergetics of muscle mitochondria in female mice fed a high fat diet Open
Our group recently documented that male mice containing a deletion for one copy of the glutaredoxin-2 (Grx2) gene were completely protected from developing diet-induced obesity (DIO). Objectives: Here, we conducted a similar investigation …
View article: Sex-dependent Differences in the Bioenergetics of Liver and Muscle Mitochondria from Mice Containing a Deletion for glutaredoxin-2
Sex-dependent Differences in the Bioenergetics of Liver and Muscle Mitochondria from Mice Containing a Deletion for glutaredoxin-2 Open
Our group recently published a study demonstrating that deleting the gene encoding the matrix thiol oxidoreductase, glutaredoxin-2 (GRX2), alters the bioenergetics of mitochondria isolated from male C57BL/6N mice. Here, we conducted a simi…
View article: Deletion of the Glutaredoxin-2 Gene Protects Mice from Diet-Induced Weight Gain, Which Correlates with Increased Mitochondrial Respiration and Proton Leaks in Skeletal Muscle
Deletion of the Glutaredoxin-2 Gene Protects Mice from Diet-Induced Weight Gain, Which Correlates with Increased Mitochondrial Respiration and Proton Leaks in Skeletal Muscle Open
Aims: The aim of this study was to determine whether deleting the gene encoding glutaredoxin-2 (GRX2) could protect mice from diet-induced weight gain. Results: Subjecting wild-type littermates to a high fat diet (HFD) induced a significan…
View article: Simultaneous Measurement of Superoxide/Hydrogen Peroxide and NADH Production by Flavin-containing Mitochondrial Dehydrogenases
Simultaneous Measurement of Superoxide/Hydrogen Peroxide and NADH Production by Flavin-containing Mitochondrial Dehydrogenases Open
It has been reported that mitochondria can contain up to 12 enzymatic sources of reactive oxygen species (ROS). A majority of these sites include flavin-dependent respiratory complexes and dehydrogenases that produce a mixture of superoxid…
View article: Protein S-glutathionylation lowers superoxide/hydrogen peroxide release from skeletal muscle mitochondria through modification of complex I and inhibition of pyruvate uptake
Protein S-glutathionylation lowers superoxide/hydrogen peroxide release from skeletal muscle mitochondria through modification of complex I and inhibition of pyruvate uptake Open
Protein S-glutathionylation is a reversible redox modification that regulates mitochondrial metabolism and reactive oxygen species (ROS) production in liver and cardiac tissue. However, whether or not it controls ROS release from skeletal …