Robert M. J. Deacon
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View article: Octodon degus laboratory colony management principles and methods for behavioral analysis for Alzheimer’s disease neuroscience research
Octodon degus laboratory colony management principles and methods for behavioral analysis for Alzheimer’s disease neuroscience research Open
The Chilean degu ( Octodon degus ) is a medium sized, long-lived rodent with traits that make them a natural model for neuroscience research. Their social behaviors, diurnality, and extended developmental time course, when compared to othe…
View article: Microbiome alterations are associated with apolipoprotein E mutation in Octodon degus and humans with Alzheimer’s disease
Microbiome alterations are associated with apolipoprotein E mutation in Octodon degus and humans with Alzheimer’s disease Open
Gut microbiome dysbiosis is linked to many neurological disorders including Alzheimer's disease (AD). A major risk factor for AD is polymorphism in the apolipoprotein E (APOE) gene, which affects gut microbiome composition. To explore the …
View article: Effects of environmental enrichment on the behavioural consequences of early-life stress in rats
Effects of environmental enrichment on the behavioural consequences of early-life stress in rats Open
Background: Maternal separation (MS) is a major cause of chronic life stress and increased risk of psychiatric illness.Environmental enrichment (EE) enhances brain plasticity and neurogenesis.We investigated the consequences of maternal se…
View article: Genome Sequencing Variations in the Octodon degus, an Unconventional Natural Model of Aging and Alzheimer's Disease
Genome Sequencing Variations in the Octodon degus, an Unconventional Natural Model of Aging and Alzheimer's Disease Open
The degu ( Octodon degus ) is a diurnal long-lived rodent that can spontaneously develop molecular and behavioral changes that mirror those seen in human aging. With age some degu, but not all individuals, develop cognitive decline and bra…
View article: Spatial maps and oscillations in the healthy hippocampus of Octodon degus, a natural model of sporadic Alzheimer’s disease
Spatial maps and oscillations in the healthy hippocampus of Octodon degus, a natural model of sporadic Alzheimer’s disease Open
The Octodon degus is a South American rodent that is receiving increased attention as a potential model of aging and sporadic late-onset Alzheimer’s disease (AD). Impairments in spatial memory tasks in Octodon degus have been reported in r…
View article: Reversal of behavioural phenotype by the cannabinoid-like compound VSN16R in fragile X syndrome mice
Reversal of behavioural phenotype by the cannabinoid-like compound VSN16R in fragile X syndrome mice Open
Fragile X syndrome is the most common inherited intellectual disability and mono-genetic cause of autism spectrum disorder. It is a neurodevelopmental condition occurring due to a CGG trinucleotide expansion in the FMR1 gene. Polymorphisms…
View article: Altered Gut Microbiota in a Fragile X Syndrome Mouse Model
Altered Gut Microbiota in a Fragile X Syndrome Mouse Model Open
The human gut microbiome is the ecosystem of microorganisms that live in the human digestive system. Several studies have related gut microbiome variants to metabolic, immune and nervous system disorders. Fragile X syndrome (FXS) is a neur…
View article: Effects of the Sigma-1 Receptor Agonist Blarcamesine in a Murine Model of Fragile X Syndrome: Neurobehavioral Phenotypes and Receptor Occupancy
Effects of the Sigma-1 Receptor Agonist Blarcamesine in a Murine Model of Fragile X Syndrome: Neurobehavioral Phenotypes and Receptor Occupancy Open
Fragile X syndrome (FXS), a disorder of synaptic development and function, is the most prevalent genetic form of intellectual disability and autism spectrum disorder. FXS mouse models display clinically-relevant phenotypes, such as increas…
View article: From genes to cognition: <i>Octodon degus</i>, an animal model for AD translational research
From genes to cognition: <i>Octodon degus</i>, an animal model for AD translational research Open
Background Octodon degus ( O. degus ), a long‐lived rodent, provides us with a unique opportunity to search for molecular pathways that are associated with enhanced longevity in mammals. This rodent from Chile spontaneously develops an ana…
View article: Cortical tau burden and behavioural dysfunctions in mice exposed to monosodium glutamate in early life
Cortical tau burden and behavioural dysfunctions in mice exposed to monosodium glutamate in early life Open
Although monosodium glutamate (MSG)-induced neurotoxicity has been recognized for decades, the potential similarities of the MSG model to Alzheimer's disease (AD)-type neuropathology have only recently been investigated. MSG-treated mice w…
View article: Gaboxadol Normalizes Behavioral Abnormalities in a Mouse Model of Fragile X Syndrome
Gaboxadol Normalizes Behavioral Abnormalities in a Mouse Model of Fragile X Syndrome Open
Fragile X syndrome (FXS) is the most common inherited form of intellectual disability and autism. FXS is also accompanied by attention problems, hyperactivity, anxiety, aggression, poor sleep, repetitive behaviors, and self-injury. Recent …
View article: Editorial: Human and Animal Models for Translational Research on Neurodegeneration: Challenges and Opportunities From South America
Editorial: Human and Animal Models for Translational Research on Neurodegeneration: Challenges and Opportunities From South America Open
CONICET \t
\nCONICYT/FONDECYT \t
\n1170010
\nFONDAP \t
\n15150012
\nINECO Foundation \t
\nInteramerican Development Bank (IDB)
View article: The long-lived Octodon degus as a rodent drug discovery model for Alzheimer's and other age-related diseases
The long-lived Octodon degus as a rodent drug discovery model for Alzheimer's and other age-related diseases Open
Alzheimer's disease (AD) is a multifactorial progressive neurodegenerative disease. Despite decades of research, no disease modifying therapy is available and a change of research objectives and/or development of novel research tools may b…
View article: Multiple Behavior Phenotypes of the Fragile-X Syndrome Mouse Model Respond to Chronic Inhibition of Phosphodiesterase-4D (PDE4D)
Multiple Behavior Phenotypes of the Fragile-X Syndrome Mouse Model Respond to Chronic Inhibition of Phosphodiesterase-4D (PDE4D) Open
Fragile-X syndrome (FXS) patients display intellectual disability and autism spectrum disorder due to silencing of the X-linked, fragile-X mental retardation-1 ( FMR1 ) gene. Dysregulation of cAMP metabolism is a consistent finding in pati…
View article: Brain Transcriptome Sequencing of a Natural Model of Alzheimer's Disease
Brain Transcriptome Sequencing of a Natural Model of Alzheimer's Disease Open
DATA REPORT article Front. Aging Neurosci., 20 March 2017Sec. Alzheimer's Disease and Related Dementias Volume 9 - 2017 | https://doi.org/10.3389/fnagi.2017.00064
View article: Retracted: Nrf2: a novel therapeutic target in fragile X syndrome is modulated by <scp>NNZ2566</scp>
Retracted: Nrf2: a novel therapeutic target in fragile X syndrome is modulated by <span>NNZ2566</span> Open
Retraction : “Nrf2: a novel therapeutic target in fragile X syndrome is modulated by NNZ2566” by R. M. J. Deacon, M. J. Hurley, C. M. Rebolledo, M. Snape, F. J. Altimiras, L. Farías, M. Pino, R. Biekofsky, L. Glass and P. Cogram. The above…
View article: Novel ketone diet enhances physical and cognitive performance
Novel ketone diet enhances physical and cognitive performance Open
Ketone bodies are the most energy‐efficient fuel and yield more ATP permole of substrate than pyruvate and increase the free energy released from ATP hydrolysis. Elevation of circulating ketones via high‐fat, low carbohydrate diets has bee…