Robert Manasherob
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View article: The mononuclear phagocyte system obscures the accurate diagnosis of infected joint replacements
The mononuclear phagocyte system obscures the accurate diagnosis of infected joint replacements Open
View article: Dosing and Delivery of Bacteriophage Therapy In a Murine Wound Infection Model
Dosing and Delivery of Bacteriophage Therapy In a Murine Wound Infection Model Open
Lytic bacteriophages, viruses that lyse (kill) bacteria, hold great promise for treating infections, including wound infections caused by antimicrobial-resistant Pseudomonas aeruginosa. However, dosing and delivery strategies for phage the…
View article: Immune checkpoint upregulation in periprosthetic joint infection
Immune checkpoint upregulation in periprosthetic joint infection Open
Periprosthetic joint infections (PJI) induce an immunosuppressive cytokine profile through an unknown mechanism. Immune checkpoints, like programmed cell death 1 (PD‐1) and its ligand (PD‐L1), initiate innate immunosuppressive pathways ess…
View article: The Safety and Toxicity of Phage Therapy: A Review of Animal and Clinical Studies
The Safety and Toxicity of Phage Therapy: A Review of Animal and Clinical Studies Open
Increasing rates of infection by antibiotic resistant bacteria have led to a resurgence of interest in bacteriophage (phage) therapy. Several phage therapy studies in animals and humans have been completed over the last two decades. We con…
View article: The Safety and Toxicity of Phage Therapy: A Review of Pre-Clinical and Clinical Studies
The Safety and Toxicity of Phage Therapy: A Review of Pre-Clinical and Clinical Studies Open
Increasing rates of infection by antibiotic resistant bacteria have led to a resurgence of interest in bacteriophage (phage) therapy. Several phage therapy studies in animals and humans have been completed over the last two decades. We con…
View article: Tolerant Small-colony Variants Form Prior to Resistance Within a Staphylococcus aureus Biofilm Based on Antibiotic Selective Pressure
Tolerant Small-colony Variants Form Prior to Resistance Within a Staphylococcus aureus Biofilm Based on Antibiotic Selective Pressure Open
Background The treatment of periprosthetic joint infection (PJI) is focused on the surgical or chemical removal of biofilm. Antibiotics in isolation are typically ineffective against PJI. Bacteria survive after antibiotic administration be…
View article: The Rationale for Using Bacteriophage to Treat and Prevent Periprosthetic Joint Infections
The Rationale for Using Bacteriophage to Treat and Prevent Periprosthetic Joint Infections Open
Prosthetic joint infection (PJI) is a devastating complication after a joint replacement. PJI and its treatment have a high monetary cost, morbidity, and mortality. The lack of success treating PJI with conventional antibiotics alone is re…
View article: A Delayed Inoculation Model of Chronic <em>Pseudomonas aeruginosa</em> Wound Infection
A Delayed Inoculation Model of Chronic <em>Pseudomonas aeruginosa</em> Wound Infection Open
Pseudomonas aeruginosa (P. aeruginosa) is a major nosocomial pathogen of increasing relevance to human health and disease, particularly in the setting of chronic wound infections in diabetic and hospitalized patients. There is an urgent ne…
View article: The Immune Response to Chronic <i>Pseudomonas aeruginosa</i> Wound Infection in Immunocompetent Mice
The Immune Response to Chronic <i>Pseudomonas aeruginosa</i> Wound Infection in Immunocompetent Mice Open
Objective: Our goal was to develop a chronic wound model in mice that avoids implantation of foreign material or impaired immunity and to use this to characterize the local and systemic immune response associated with Pseudomonas…
View article: Bacteriophage trigger antiviral immunity and prevent clearance of bacterial infection
Bacteriophage trigger antiviral immunity and prevent clearance of bacterial infection Open
Phage subverts immune response Pseudomonas aeruginosa ( Pa ) is a multidrug-resistant Gramnegative bacterium commonly found in health care settings. Pa infections frequently result in considerable morbidity and mortality. Sweere et al. fou…
View article: Effect of trabecular metal on the elution of gentamicin from Palacos cement
Effect of trabecular metal on the elution of gentamicin from Palacos cement Open
Periprosthetic joint infections continues to be a common complication in total joint arthroplasty, resulting in significant morbidity, mortality, and additional cost. Trabecular metal implants with an internal cemented interface may be cus…
View article: Periprosthetic bacterial biofilm and quorum sensing
Periprosthetic bacterial biofilm and quorum sensing Open
Periprosthetic joint infection (PJI) is a common complication after total joint arthroplasty leading to severe morbidity and mortality. With an aging population and increasing prevalence of total joint replacement procedures, the burden of…
View article: Bithionol blocks pathogenicity of bacterial toxins, ricin and Zika virus
Bithionol blocks pathogenicity of bacterial toxins, ricin and Zika virus Open