Samuel R. Mathias
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View article: Genetic Associations Among Inflammation, White Matter Architecture, and Extracellular Free Water
Genetic Associations Among Inflammation, White Matter Architecture, and Extracellular Free Water Open
Phenotypic and genetic relationships between white matter microstructure (i.e., fractional anisotropy [FA]) and peripheral inflammatory responses (i.e., circulating cytokines) have important implications for health and disease. However, it…
Perceptual organization and task demands jointly shape auditory working memory capacity Open
Listeners performed two different tasks in which they remembered short sequences comprising either complex tones (generally heard as one melody) or everyday sounds (generally heard as separate objects). In one, listeners judged whether a p…
View article: Cocktail-party listening and cognitive abilities show strong pleiotropy
Cocktail-party listening and cognitive abilities show strong pleiotropy Open
Introduction The cocktail-party problem refers to the difficulty listeners face when trying to attend to relevant sounds that are mixed with irrelevant ones. Previous studies have shown that solving these problems relies on perceptual as w…
The Genetic contribution to solving the cocktail-party problem Open
Communicating in everyday situations requires solving the cocktail-party problem, or segregating the acoustic mixture into its constituent sounds and attending to those of most interest. Humans show dramatic variation in this ability, lead…
Effects of copy number variations on brain structure and risk for psychiatric illness: Large‐scale studies from the<span>ENIGMA</span>working groups on<span>CNVs</span> Open
The Enhancing NeuroImaging Genetics through Meta‐Analysis copy number variant (ENIGMA‐CNV) and 22q11.2 Deletion Syndrome Working Groups (22q‐ENIGMA WGs) were created to gain insight into the involvement of genetic factors in human brain de…
1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans Open
Low-frequency 1q21.1 distal deletion and duplication copy number variant (CNV) carriers are predisposed to multiple neurodevelopmental disorders including schizophrenia, autism and intellectual disability. Human carriers display a high pre…
View article: Effects of copy number variations on brain structure and risk for psychiatric illness: Large-scale studies from the ENIGMA Working Groups on CNVs
Effects of copy number variations on brain structure and risk for psychiatric illness: Large-scale studies from the ENIGMA Working Groups on CNVs Open
The Enhancing Neuroimaging Genetics through Meta-Analysis copy number variant (ENIGMA-CNV) and 22q11.2 Deletion Syndrome Working Groups (22q-ENIGMA WGs) were created to gain insight into the involvement of genetic factors in human brain de…
Gradual decay and sudden death of short-term memory for pitch Open
The ability to discriminate frequency differences between pure tones declines as the duration of the interstimulus interval (ISI) increases. The conventional explanation for this finding is that pitch representations gradually decay from a…
View article: Genetic influences on externalizing psychopathology overlap with cognitive functioning and show developmental variation
Genetic influences on externalizing psychopathology overlap with cognitive functioning and show developmental variation Open
Background Questions remain regarding whether genetic influences on early life psychopathology overlap with cognition and show developmental variation. Methods Using data from 9,421 individuals aged 8–21 from the Philadelphia Neurodevelopm…
Dataset for: Searching for Imaging Biomarkers of Psychotic Dysconnectivity Open
This dataset contains features used in analyses for the following manuscript: Rodrigue, AL, et al. (2021). Searching for Imaging Biomarkers of Psychotic Dysconnectivity. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, in pr…
Dataset for: Searching for Imaging Biomarkers of Psychotic Dysconnectivity Open
This dataset contains features used in analyses for the following manuscript: Rodrigue, AL, et al. (2021). Searching for Imaging Biomarkers of Psychotic Dysconnectivity. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, in pr…
View article: Associations of cannabis use disorder with cognition, brain structure, and brain function in<scp>African Americans</scp>
Associations of cannabis use disorder with cognition, brain structure, and brain function in<span>African Americans</span> Open
Although previous studies have highlighted associations of cannabis use with cognition and brain morphometry, critical questions remain with regard to the association between cannabis use and brain structural and functional connectivity. I…
The architecture of co-morbidity networks of physical and mental health conditions in military veterans Open
Co-morbidity between medical and psychiatric conditions is commonly considered between individual pairs of conditions. However, an important alternative is to consider all conditions as part of a co-morbidity network, which encompasses all…
The architecture of co-morbidity networks of physical and mental health conditions in military veterans Open
Co-morbidity between medical and psychiatric conditions is commonly considered between individual pairs of conditions. However, an important alternative is to consider all conditions as part of a co-morbidity network, which encompasses all…
Mapping brain asymmetry in health and disease through the <span>ENIGMA</span> consortium Open
Left–right asymmetry of the human brain is one of its cardinal features, and also a complex, multivariate trait. Decades of research have suggested that brain asymmetry may be altered in psychiatric disorders. However, findings have been i…
Mapping brain asymmetry in health and disease through the ENIGMA consortium Open
The results leading to this publication have received funding from the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement No 777394 for the project AIMS-2-TRIALS. This Joint Undertaking receives support from the Euro…
View article: T67. TRAUMA IN AFFECTIVE AND NONAFFECTIVE PSYCHOSIS: ASSOCIATIONS AND DISSOCIATIONS WITH COGNITIVE FUNCTIONING IN CHILDHOOD AND ADULTHOOD
T67. TRAUMA IN AFFECTIVE AND NONAFFECTIVE PSYCHOSIS: ASSOCIATIONS AND DISSOCIATIONS WITH COGNITIVE FUNCTIONING IN CHILDHOOD AND ADULTHOOD Open
Background Childhood trauma and cognitive impairment are important risk factors for psychotic disorders. However, the relationship between trauma and psychosis throughout the lifespan, as well as between lifetime trauma and cognitive funct…
The genetic architecture of the human cerebral cortex Open
INTRODUCTION The cerebral cortex underlies our complex cognitive capabilities. Variations in human cortical surface area and thickness are associated with neurological, psychological, and behavioral traits and can be measured in vivo by ma…
View article: Genetic Contributions to Multivariate Data-Driven Brain Networks Constructed via Source-Based Morphometry
Genetic Contributions to Multivariate Data-Driven Brain Networks Constructed via Source-Based Morphometry Open
Identifying genetic factors underlying neuroanatomical variation has been difficult. Traditional methods have used brain regions from predetermined parcellation schemes as phenotypes for genetic analyses, although these parcellations often…
View article: Imaging local genetic influences on cortical folding
Imaging local genetic influences on cortical folding Open
Significance Major gaps remain in our understanding of mechanisms that underlie the folding of the human cerebral cortex. Stereotyped folding in specific cortical locations could be explained by a corresponding anatomical pattern of geneti…